Imperial College London
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ProfessorMichaelLevin

Faculty of Medicine, Department of Infectious Disease

Chair in Paediatrics & International Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3760m.levin Website

 
 
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Location

 

233Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{O'Connor:2020:10.15252/msb.20209888,
author = {O'Connor, D and Pinto, MV and Sheerin, D and Tomic, A and Drury, RE and Channon-Wells, S and Galal, U and Dold, C and Robinson, H and Kerridge, S and Plested, E and Hughes, H and Stockdale, L and Sadarangani, M and Snape, MD and Rollier, CS and Levin, M and Pollard, AJ},
doi = {10.15252/msb.20209888},
journal = {Molecular Systems Biology},
pages = {1--19},
title = {Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine},
url = {http://dx.doi.org/10.15252/msb.20209888},
volume = {16},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Neisseria meningitidis is a major cause of meningitis and septicaemia. A MenB vaccine (4CMenB) was licensed by the European Medicines Agency in January 2013. Here we describe the blood transcriptome and proteome following infant immunisations with or without concomitant 4CMenB, to gain insight into the molecular mechanisms underlying post-vaccination reactogenicity and immunogenicity. Infants were randomised to receive control immunisations (PCV13 and DTaP-IPV-Hib) with or without 4CMenB at 2 and 4 months of age. Blood gene expression and plasma proteins were measured prior to, then 4 h, 24 h, 3 days or 7 days post-vaccination. 4CMenB vaccination was associated with increased expression of ENTPD7 and increased concentrations of 4 plasma proteins: CRP, G-CSF, IL-1RA and IL-6. Post-vaccination fever was associated with increased expression of SELL, involved in neutrophil recruitment. A murine model dissecting the vaccine components found the concomitant regimen to be associated with increased gene perturbation compared with 4CMenB vaccine alone with enhancement of pathways such as interleukin-3, -5 and GM-CSF signalling. Finally, we present transcriptomic profiles predictive of immunological and febrile responses following 4CMenB vaccine.
AU  - O'Connor,D
AU  - Pinto,MV
AU  - Sheerin,D
AU  - Tomic,A
AU  - Drury,RE
AU  - Channon-Wells,S
AU  - Galal,U
AU  - Dold,C
AU  - Robinson,H
AU  - Kerridge,S
AU  - Plested,E
AU  - Hughes,H
AU  - Stockdale,L
AU  - Sadarangani,M
AU  - Snape,MD
AU  - Rollier,CS
AU  - Levin,M
AU  - Pollard,AJ
DO  - 10.15252/msb.20209888
EP  - 19
PY  - 2020///
SN  - 1744-4292
SP  - 1
TI  - Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine
T2  - Molecular Systems Biology
UR  - http://dx.doi.org/10.15252/msb.20209888
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000596014200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.embopress.org/doi/full/10.15252/msb.20209888
UR  - http://hdl.handle.net/10044/1/91425
VL  - 16
ER  -
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