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@article{Boeddha:2021:10.1097/CCE.0000000000000569,
author = {Boeddha, NP and Driessen, GJ and Hagedoorn, NN and Kohlfuerst, DS and Hoggart, CJ and van, Rijswijk AL and Ekinci, E and Priem, D and Schlapbach, LJ and Herberg, JA and de, Groot R and Anderson, ST and Fink, CG and Carrol, ED and van, der Flier M and Martinón-Torres, F and Levin, M and Leebeek, FW and Zenz, W and de, Maat MPM and Hazelzet, JA and Emonts, M and Dik, WA},
doi = {10.1097/CCE.0000000000000569},
journal = {Critical Care Explorations},
pages = {1--12},
title = {Detectable a disintegrin and metalloproteinase with thrombospondin motifs-1 in serum is associated with adverse outcome in pediatric sepsis.},
url = {http://dx.doi.org/10.1097/CCE.0000000000000569},
volume = {3},
year = {2021}
}

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TY  - JOUR
AB  - IMPORTANCE: A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking. OBJECTIVES: To study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric sepsis and to study the association with outcome. DESIGN: Data from two prospective cohort studies. SETTING AND PARTICIPANTS: Cohort 1 is from a single-center study involving children admitted to PICU with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission). MAIN OUTCOMES AND MEASURES: Primary outcome measure was mortality. Secondary outcome measures were PICU-free days at day 28 and hospital length of stay. RESULTS: In cohort 1 (n = 59), nonsurvivors more frequently had A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels above the detection limit than survivors at admission to PICU (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with Neisseria meningitidis. CONCLUSIONS AND RELEVANCE: In children with bacterial infection, detection of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 within 48 hours after hospital admission is associated with deat
AU  - Boeddha,NP
AU  - Driessen,GJ
AU  - Hagedoorn,NN
AU  - Kohlfuerst,DS
AU  - Hoggart,CJ
AU  - van,Rijswijk AL
AU  - Ekinci,E
AU  - Priem,D
AU  - Schlapbach,LJ
AU  - Herberg,JA
AU  - de,Groot R
AU  - Anderson,ST
AU  - Fink,CG
AU  - Carrol,ED
AU  - van,der Flier M
AU  - Martinón-Torres,F
AU  - Levin,M
AU  - Leebeek,FW
AU  - Zenz,W
AU  - de,Maat MPM
AU  - Hazelzet,JA
AU  - Emonts,M
AU  - Dik,WA
DO  - 10.1097/CCE.0000000000000569
EP  - 12
PY  - 2021///
SN  - 2639-8028
SP  - 1
TI  - Detectable a disintegrin and metalloproteinase with thrombospondin motifs-1 in serum is associated with adverse outcome in pediatric sepsis.
T2  - Critical Care Explorations
UR  - http://dx.doi.org/10.1097/CCE.0000000000000569
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34765980
UR  - https://journals.lww.com/ccejournal/Fulltext/2021/11000/Detectable_A_Disintegrin_and_Metalloproteinase.12.aspx
UR  - http://hdl.handle.net/10044/1/98680
VL  - 3
ER  -

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