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@article{Hagedoorn:2022:10.1097/PCC.0000000000003056,
author = {Hagedoorn, NN and Boeddha, NP and Kohlfuerst, DS and Anderson, S and Carrol, ED and Agapow, P and van, der Flier M and Hazelzet, J and Herberg, J and Kuijpers, T and Levin, M and Martinon-Torres, F and van, Rijswijk A and Schlapbach, LJ and Vermont, C and Zenz, W and Dik, WA and Driessen, G and Emonts, M and EUCLIDS, Consortium},
doi = {10.1097/PCC.0000000000003056},
journal = {Pediatric Critical Care Medicine},
pages = {e543--e554},
title = {Hemostasis proteins in invasive meningococcal and nonmeningococcal infections: a prospective multicenter study.},
url = {http://dx.doi.org/10.1097/PCC.0000000000003056},
volume = {23},
year = {2022}
}

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TY  - JOUR
AB  - OBJECTIVES: We aimed to describe the variation of hemostasis proteins in children with bacterial infections due to different pathogens (Neisseria meningitidis, Streptococcus pneumoniae, Staphylococcus aureus, and group A streptococcus [GAS]) and to study hemostasis proteins in relation to mortality. DESIGN: Preplanned analysis in prospective cohort study. SETTING: Hospitals in five European countries (Austria, The Netherlands, Spain, Switzerland, and the United Kingdom). PATIENTS: Admitted children (2012-2016) with community-acquired infections due to meningococci (n = 83), pneumococci (n = 64), S. aureus (n = 50), and GAS (n = 44) with available serum samples collected less than 48 hours after admission. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Fibronectin, plasminogen activator inhibitor type 1 (PAI-1), thrombomodulin, and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13) were measured in serum in 2019-2020. Additionally, von Willebrand factor, protein C, protein S, and factor IX were measured in citrate plasma available from a subset of patients. Outcome measures included in-hospital mortality and disease severity (need for ventilation/inotropes, Pediatric Index of Mortality score). Of 241 children, 21 (8.7%) died and 177 (73.5%) were admitted to PICU. Mortality rate was similar for the pathogen groups. Levels of fibronectin and thrombomodulin differed for the different pathogens (p < 0.05). Fibronectin levels were lower in GAS infections than in S. pneumoniae and S. aureus infections but did not differ from meningococcal infections. Thrombomodulin levels in meningococcal infections were higher than in S. aureus and pneumococcal infections. Overall, the area under the curve for mortality was 0.81 (95% CI, 0.70-0.92) for thrombomodulin and 0.78 (95% CI, 0.69-0.88) for ADAMTS-13. The association of each hemostasis protein did not vary across pathogens for any of the outcome measures. CONCLUSIONS: Hemostatic
AU  - Hagedoorn,NN
AU  - Boeddha,NP
AU  - Kohlfuerst,DS
AU  - Anderson,S
AU  - Carrol,ED
AU  - Agapow,P
AU  - van,der Flier M
AU  - Hazelzet,J
AU  - Herberg,J
AU  - Kuijpers,T
AU  - Levin,M
AU  - Martinon-Torres,F
AU  - van,Rijswijk A
AU  - Schlapbach,LJ
AU  - Vermont,C
AU  - Zenz,W
AU  - Dik,WA
AU  - Driessen,G
AU  - Emonts,M
AU  - EUCLIDS,Consortium
DO  - 10.1097/PCC.0000000000003056
EP  - 554
PY  - 2022///
SN  - 1529-7535
SP  - 543
TI  - Hemostasis proteins in invasive meningococcal and nonmeningococcal infections: a prospective multicenter study.
T2  - Pediatric Critical Care Medicine
UR  - http://dx.doi.org/10.1097/PCC.0000000000003056
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36044313
UR  - https://journals.lww.com/pccmjournal/Fulltext/9900/Hemostasis_Proteins_in_Invasive_Meningococcal_and.76.aspx
UR  - http://hdl.handle.net/10044/1/99565
VL  - 23
ER  -

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