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@article{Dewez:2022:10.1371/journal.pone.0275336,
author = {Dewez, JE and Pembrey, L and Nijman, RG and Del, Torso S and Grossman, Z and Hadjipanayis, A and Van, Esso D and Lim, E and Emonts, M and Burns, J and Gras-LeGuen, C and Kohlfuerst, D and Dornbusch, HJ and Brengel-Pesce, K and Mallet, F and von, Both U and Tsolia, M and Eleftheriou, I and Zavadska, D and de, Groot R and van, der Flier M and Moll, H and Hagedoorn, N and Borensztajn, D and Oostenbrink, R and Kuijpers, T and Pokorn, M and Vincek, K and Martinón-Torres, F and Rivero, I and Agyeman, P and Carrol, ED and Paulus, S and Cunnington, A and Herberg, J and Levin, M and Mujki, A and Geitmann, K and Da, Dalt L and Valiulis, A and Lapatto, R and Syridou, G and Altorjai, P and Torpiano, P and Størdal, K and Illy, K and Mazur, A and Spreitzer, MV and Rios, J and Wyder, C and Romankevych, I and Basmaci, R and Ibanez-Mico, S and Yeung, S},
doi = {10.1371/journal.pone.0275336},
journal = {PLoS One},
pages = {1--22},
title = {Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians.},
url = {http://dx.doi.org/10.1371/journal.pone.0275336},
volume = {17},
year = {2022}
}

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TY  - JOUR
AB  - BACKGROUND: Point-of-care-tests (POCTs) have been advocated to optimise care in patients with infections but their actual use varies. This study aimed to estimate the variability in the adoption of current POCTs by paediatricians across Europe, and to explore the determinants of variability. METHODS AND FINDINGS: A cross-sectional survey was conducted of hospital and primary care paediatricians, recruited through professional networks. Questions focused on the availability and use of currently available POCTs. Data were analysed descriptively and using Median Odds Ratio (MOR) to measure variation between countries. Multilevel regression modelling using changes in the area under the receiver operating characteristic curve of models were used to assess the contribution of individual or workplace versus country level factors, to the observed variation. The commonest POCT was urine dipsticks (UD) which were available to >80% of primary care and hospital paediatricians in 68% (13/19) and 79% (23/29) countries, respectively. Availability of all POCTs varied between countries. In primary care, the country (MOR) varied from 1.61 (95%CI: 1.04-2.58) for lactate to 7.28 (95%CI: 3.04-24.35) for UD. In hospitals, the country MOR varied from 1.37 (95%CI:1.04-1.80) for lactate to 11.93 (95%CI:3.35-72.23) for UD. Most paediatricians in primary care (69%, 795/1154) and hospital (81%, 962/1188) would use a diagnostic test in the case scenario of an infant with undifferentiated fever. Multilevel regression modelling showed that the country of work was more important in predicting both the availability and use of POCTs than individual or workplace characteristics. CONCLUSION: There is substantial variability in the adoption of POCTs for the management of acute infections in children across Europe. To inform future implementation of both existing and innovative tests, further research is needed to understand what drives the variation between countries, the needs of frontline clinicia
AU  - Dewez,JE
AU  - Pembrey,L
AU  - Nijman,RG
AU  - Del,Torso S
AU  - Grossman,Z
AU  - Hadjipanayis,A
AU  - Van,Esso D
AU  - Lim,E
AU  - Emonts,M
AU  - Burns,J
AU  - Gras-LeGuen,C
AU  - Kohlfuerst,D
AU  - Dornbusch,HJ
AU  - Brengel-Pesce,K
AU  - Mallet,F
AU  - von,Both U
AU  - Tsolia,M
AU  - Eleftheriou,I
AU  - Zavadska,D
AU  - de,Groot R
AU  - van,der Flier M
AU  - Moll,H
AU  - Hagedoorn,N
AU  - Borensztajn,D
AU  - Oostenbrink,R
AU  - Kuijpers,T
AU  - Pokorn,M
AU  - Vincek,K
AU  - Martinón-Torres,F
AU  - Rivero,I
AU  - Agyeman,P
AU  - Carrol,ED
AU  - Paulus,S
AU  - Cunnington,A
AU  - Herberg,J
AU  - Levin,M
AU  - Mujki,A
AU  - Geitmann,K
AU  - Da,Dalt L
AU  - Valiulis,A
AU  - Lapatto,R
AU  - Syridou,G
AU  - Altorjai,P
AU  - Torpiano,P
AU  - Størdal,K
AU  - Illy,K
AU  - Mazur,A
AU  - Spreitzer,MV
AU  - Rios,J
AU  - Wyder,C
AU  - Romankevych,I
AU  - Basmaci,R
AU  - Ibanez-Mico,S
AU  - Yeung,S
DO  - 10.1371/journal.pone.0275336
EP  - 22
PY  - 2022///
SN  - 1932-6203
SP  - 1
TI  - Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians.
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0275336
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36538525
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275336
UR  - http://hdl.handle.net/10044/1/101144
VL  - 17
ER  -

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