Publications
262 results found
Alfahl Z, Einarsson GG, O'Neill K, et al., 2021, Changes in sputum bacterial density in people with bronchiectasis: BRONCH UK Study data, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Nwankwo L, McLaren K, Donovan J, et al., 2021, Utilisation of remote capillary blood testing in an outpatient clinic setting to improve shared decision making and patient and clinician experience: a validation and pilot study, BMJ Open Quality, Vol: 10, Pages: 1-11, ISSN: 2399-6641
Background In a tertiary respiratory centre, large cohorts of patients are managed in an outpatient setting and require blood tests to monitor disease activity and organ toxicity. This requires either visits to tertiary centres for phlebotomy and physician review or utilisation of primary care services.Objectives This study aims to validate remote capillary blood testing in an outpatient setting and analyse impact on clinical pathways.Methods A single-centre prospective cross-sectional validation and parallel observational study was performed. Remote finger prick capillary blood testing was validated compared with local standard venesection using comparative statistical analysis: paired t-test, correlation and Bland-Altman. Capillary was considered interchangeable with venous samples if all three criteria were met: non-significant paired t-test (ie, p>0.05), Pearson’s correlation coefficient (r)>0.8% and 95% of tests within 10% difference through Bland-Altman (limits of agreement). In parallel, current clinical pathways including phlebotomy practice were analysed over 4 weeks to review test predictability. A subsequent pilot cohort study analysed potential impact of remote capillary blood sampling on shared decision making. A final implementation phase ensued to embed the service into clinical pathways within the institution.Results 117 paired capillary and venous blood samples were prospectively analysed. Interchangeability with venous blood was seen with glycated haemoglobin (%), total protein and C reactive protein. Further tests, although not interchangeable, are likely useful to enable longitudinal remote monitoring (eg, liver function and total IgE). 65% of outpatient clinic blood tests were predictable with 16% of patients requiring further follow-up. Patient and clinician-reported improvement in shared decision making given contemporaneous blood test results was observed.Conclusions Remote capillary blood sampling can be used accurately fo
Shoemark A, Rubbo B, Legendre M, et al., 2021, Topological data analysis reveals genotype-phenotype relationships in primary ciliary dyskinesia, EUROPEAN RESPIRATORY JOURNAL, Vol: 58, ISSN: 0903-1936
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- Citations: 26
Jose RJ, Loebinger MR, 2021, Clinical and Radiological Phenotypes and Endotypes, SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 42, Pages: 549-555, ISSN: 1069-3424
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- Citations: 3
van Ingen J, Aliberti S, Andrejak C, et al., 2021, Management of Drug Toxicity in <i>Mycobacterium avium</i> Complex Pulmonary Disease: An Expert Panel Survey, CLINICAL INFECTIOUS DISEASES, Vol: 73, Pages: E256-E259, ISSN: 1058-4838
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- Citations: 7
Rademacher J, Dettmer S, Fuge J, et al., 2021, The Primary Ciliary Dyskinesia Computed Tomography Score in Adults with Bronchiectasis: A Derivation und Validation Study, RESPIRATION, Vol: 100, Pages: 499-509, ISSN: 0025-7931
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- Citations: 2
De Soyza A, Mawson P, Hill AT, et al., 2021, BronchUK: protocol for an observational cohort study and biobank in bronchiectasis, ERJ OPEN RESEARCH, Vol: 7
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- Citations: 4
Cuthbertson L, Felton I, James P, et al., 2021, The fungal airway microbiome in cystic fibrosis and non-cystic fibrosis bronchiectasis, Journal of Cystic Fibrosis, Vol: 20, Pages: 295-302, ISSN: 1569-1993
BackgroundThe prevalence of fungal disease in cystic fibrosis (CF) and non-CF bronchiectasis is increasing and the clinical spectrum is widening. Poor sensitivity and a lack of standard diagnostic criteria renders interpretation of culture results challenging. In order to develop effective management strategies, a more accurate and comprehensive understanding of the airways fungal microbiome is required. The study aimed to use DNA sequences from sputum to assess the load and diversity of fungi in adults with CF and non-CF bronchiectasis.MethodsNext generation sequencing of the ITS2 region was used to examine fungal community composition (n = 176) by disease and underlying clinical subgroups including allergic bronchopulmonary aspergillosis, chronic necrotizing pulmonary aspergillosis, non-tuberculous mycobacteria, and fungal bronchitis. Patients with no known active fungal disease were included as disease controls.ResultsITS2 sequencing greatly increased the detection of fungi from sputum. In patients with CF fungal diversity was lower, while burden was higher than those with non-CF bronchiectasis. The most common operational taxonomic unit (OTU) in patients with CF was Candida parapsilosis (20.4%), whereas in non-CF bronchiectasis sputum Candida albicans (21.8%) was most common. CF patients with overt fungal bronchitis were dominated by Aspergillus spp., Exophiala spp., Candida parapsilosis or Scedosporium spp.ConclusionThis study provides a framework to more accurately characterize the extended spectrum of fungal airways diseases in adult suppurative lung diseases.
Hughes DA, Cuthbertson L, Price H, et al., 2021, PSEUDOMONAS AERUGINOSA IMPAIRS GROWTH OF ASPERGILLUS FROM CF AIRWAY SAMPLES, Publisher: BMJ PUBLISHING GROUP, Pages: A159-A159, ISSN: 0040-6376
Stowell JM, José RJ, Loebinger MR, et al., 2021, Bronchiectasis, Encyclopedia of Respiratory Medicine, Second Edition, Pages: 266-279, ISBN: 9780081027233
Bronchiectasis is abnormal chronic dilatation of one or more bronchi due to loss of structural elements in the bronchial wall. There are a number of known causes and several associated conditions, but the underlying cause is not known in many cases. The prevalence is unknown, but thin-section computed tomography has increased its recognition. Symptoms are of chronic productive cough, breathlessness, recurrent exacerbations usually provoked by infection, and tiredness. There may be crackles over affected areas but not in all cases, and there may be wheezes due to airflow obstruction that is largely irreversible. Subsegmental airways are permanently dilated, tortuous, and contain excess secretions. Characteristically, the elastin layer of the wall is deficient, and muscle and cartilage show signs of destruction. Increased mucus production and impaired clearance predispose to bacterial infection, which stimulates chronic inflammation in which lymphocytes predominate within the wall and neutrophils in the lumen. The inflammation causes more damage, which in turn further impairs the lung defenses, leading to more infection and a vicious cycle of events. Treatment involves daily physiotherapy to drain affected areas and appropriate antibiotics to treat infection and thus reduce inflammation.
Loebinger MR, Polverino E, Chalmers JD, et al., 2021, Efficacy and safety of TOBI Podhaler in <i>Pseudomonas aeruginosa</i>-infected bronchiectasis patients: iBEST study, EUROPEAN RESPIRATORY JOURNAL, Vol: 57, ISSN: 0903-1936
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- Citations: 29
Chalmers JD, Haworth CS, Metersky ML, et al., 2020, Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 383, Pages: 2127-2137, ISSN: 0028-4793
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- Citations: 115
O'Neill K, Ferguson K, Cosgrove D, et al., 2020, Multiple Breath Washout (MBW) in bronchiectasis clinical trials – Is it feasible?, European Respiratory Journal, Vol: 6, Pages: 1-10, ISSN: 0903-1936
Background: Evaluation of Multiple Breath Washout (MBW) set-up including staff training, certification and central “over-reading” for data quality control is essential to determine the feasibility of MBW in future bronchiectasis studies. Aims: To assess the outcomes of a MBW training, certification and central over-reading programme. Methods: MBW training and certification was conducted in European sites collecting LCI data in the BronchUK clinimetrics and/or i-BEST-1 studies. The blended training programme included the use of an eLearning tool and a 1-day face-to-face session. Sites submitted MBW data to trained central over-readers who determined validity and quality. Results: Thirteen training days were delivered to 56 participants from 22 sites. 18/22 (82%) were MBW naïve. Participant knowledge and confidence increased significantly (p<0.001). By the end of the study recruitment, 15/22 sites (68%) had completed certification with a mean (range) time since training of 6.2 (3-14) months. In the BronchUK clinimetrics study, 468/589 (79%) tests met45 the quality criteria following central over-reading, compared with 137/236 (58%) tests in the i-BEST-1 study. Conclusions: LCI is feasible in a bronchiectasis multicentre clinical trial setting however, consideration of site experience in terms of training as well as assessment of skill drift and the need for re-training may be important to reduce time to certification and optimise data quality. Longer times to certification, a higher percentage of naive sites and patients with worse lung function may have contributed to the lower success rate in the i-BEST-1 study.
Doyle OM, van der Laan R, Obradovic M, et al., 2020, Identification of potentially undiagnosed patients with nontuberculous mycobacteria lung disease using machine learning applied to primary care data in the UK, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, Pages: S879-S879, ISSN: 0903-1936
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- Citations: 13
Hughes D, Cuthbertson L, Price H, et al., 2020, <i>PSEUDOMONAS AERUGINOSA</i> IMPAIRS GROWTH OF <i>ASPERGILLUS</i> FROM CF AIRWAY SAMPLES, Publisher: WILEY, Pages: S153-S153, ISSN: 8755-6863
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- Citations: 1
Wheway G, Legebeke J, Carr SB, et al., 2020, Primary ciliary dyskinesia and non-CF bronchiectasis Project, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Loebinger M, Aliberti S, Menendez R, et al., 2020, Alpha-1 antitrypsin deficiency in patients with bronchiectasis: data from the European Bronchiectasis Registry EMBARC, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Gao Y, Lonergan M, Abo-Leyah H, et al., 2020, Placebo effects in pharmaceutical clinical trials in bronchiectasis: an EMBARC study, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Mitchelmore P, Polverino E, Rademacher J, et al., 2020, Immunodeficiency associated bronchiectasis in the European Bronchiectasis Registry (EMBARC), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Spinou A, Aliberti S, Menendez R, et al., 2020, Airway clearance techniques in patients with bronchiectasis. Data from the EMBARC Registry, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 3
Shoemark A, Finch S, Torres A, et al., 2020, Sex related differences in aetiology, severity and quality of life in bronchiectasis: data from the EMBARC, EMBARC-India and Australian bronchiectasis registries, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Chalmers JD, Haworth C, Metersky M, et al., 2020, Late Breaking Abstract - Efficacy of DPP1 inhibition with brensocatib in subgroups of patients with bronchiectasis-the WILLOW study, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Loebinger M, Polverino E, Blasi F, et al., 2020, Efficacy of inhaled dry powder tobramycin (TOBI Podhaler) in P. aeruginosa infected patients with bronchiectasis - iBEST study, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Carreto L, Morrison M, Donovan J, et al., 2020, Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis, THORAX, Vol: 75, Pages: 592-593, ISSN: 0040-6376
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- Citations: 14
Wynne SC, Patel S, Barker RE, et al., 2020, Anxiety and depression in bronchiectasis: Response to pulmonary rehabilitation and minimal clinically important difference of the Hospital Anxiety and Depression Scale., Chronic Respiratory Disease, Vol: 17, Pages: 1-9, ISSN: 1479-9723
The aims of the study were to evaluate the responsiveness of Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale and HADS-Depression (HADS-D) subscale to pulmonary rehabilitation (PR) in patients with bronchiectasis compared to a matched group of patients with chronic obstructive pulmonary disease (COPD) and provide estimates of the minimal clinically important difference (MCID) of HADS-A and HADS-D in bronchiectasis. Patients with bronchiectasis and at least mild anxiety or depression (HADS-A ≥ 8 or/and HADS-D ≥ 8), as well as a propensity score-matched control group of patients with COPD, underwent an 8-week outpatient PR programme (two supervised sessions per week). Within- and between-group changes were calculated in response to PR. Anchor- and distribution-based methods were used to estimate the MCID. HADS-A and HADS-D improved in response to PR in both patients with bronchiectasis and those with COPD (median (25th, 75th centile)/mean (95% confidence interval) change: HADS-A change: bronchiectasis -2 (-5, 0), COPD -2 (-4, 0); p = 0.43 and HADS-D change: bronchiectasis -2 (-2 to -1), COPD -2 (-3 to -2); p = 0.16). Using 26 estimates, the MCID for HADS-A and HADS-D was -2 points. HADS-A and HADS-D are responsive to PR in patients with bronchiectasis and symptoms of mood disorder, with an MCID estimate of -2 points.
Osborne W, Fernandes M, Brooks S, et al., 2020, Pulsed echinocandin therapy in azole intolerant or multiresistant chronic pulmonary aspergillosis: A retrospective review at a UK tertiary centre, CLINICAL RESPIRATORY JOURNAL, Vol: 14, Pages: 571-577, ISSN: 1752-6981
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- Citations: 3
Sironen A, Shoemark A, Patel M, et al., 2020, Sperm defects in primary ciliary dyskinesia and related causes of male infertility, CELLULAR AND MOLECULAR LIFE SCIENCES, Vol: 77, Pages: 2029-2048, ISSN: 1420-682X
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- Citations: 99
Chua F, Armstrong-James D, Desai SR, et al., 2020, The role of CT in case ascertainment and management of COVID-19 pneumonia in the UK: insights from high-incidence regions, The Lancet Respiratory Medicine, Vol: 8, Pages: 438-440, ISSN: 2213-2600
Fassad MR, Patel MP, Shoemark A, et al., 2020, Clinical utility of NGS diagnosis and disease stratification in a multiethnic primary ciliary dyskinesia cohort, JOURNAL OF MEDICAL GENETICS, Vol: 57, Pages: 322-330, ISSN: 0022-2593
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- Citations: 40
Ewen R, Loebinger M, Aliberti S, et al., 2020, Initial Detection of non-tuberculous Mycobacteria in Patients with Bronchiectasis Disease - Data from the European Bronchiectasis Register EMBARC, Publisher: GEORG THIEME VERLAG KG, Pages: S8-S8, ISSN: 0934-8387
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