Imperial College London
Alternate

Professor Michael Loebinger

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Respiratory Medicine)
 
 
 
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Contact

 

+44 (0)20 7351 8337m.loebinger

 
 
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Location

 

Fulham RoadRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

262 results found

Zusag M, Angheleanu R, Norhan H, Nwankwo L, Periselneris J, Armstrong-James D, Loebinger MR, Desai SR, Semple T, Angelini E, Shah Aet al., 2018, WEAKLY SUPERVISED DEEP LEARNING ON CT SCANS PREDICTS SURVIVAL FROM CHRONIC PULMONARY ASPERGILLOSIS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A110-A111, ISSN: 0040-6376

Conference paper

Stagg HR, Abbara A, Alexander E, Baker L, Booth H, Bothamley GH, Burgess H, Cosgrove C, Davidson JA, Dunleavy A, Gupta U, Holden E, Kahr V, Kon OM, Kunst H, Lalor MK, Lipman MCI, Loebinger MR, Loutet MG, Lozewicz S, McHugh TD, Milburn HJ, Palchaudhuri P, Perrin FM, Phillips PPJ, Rahman A, Schmok E, Abubakar Iet al., 2018, INVESTIGATING THE ROLE OF FLUOROQUINOLONES IN THE TREATMENT OF ISONIAZID RESISTANT TUBERCULOSIS: IMPLICATIONS FOR THE 2018 WHO GUIDANCE, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A94-A95, ISSN: 0040-6376

Conference paper

O'Neill K, Lakshmipathy GR, Ferguson K, Cosgrove D, Hill AT, Loebinger MR, Carroll M, Chalmers JD, Gatheral T, Johnson C, DeSoyza A, Hurst JR, Bradbury I, Elborn JS, Bradley JMet al., 2018, Quality control for multiple breath washout tests in multicentre bronchiectasis studies: Experiences from the BRONCH-UK clinimetrics study, RESPIRATORY MEDICINE, Vol: 145, Pages: 206-211, ISSN: 0954-6111

Journal article

Aliberti S, Farr A, Tabin N, Blasi F, Torres A, Woodhead M, Migliori GB, Sotgiu G, Dimopoulos G, Chalmers JD, Ringshausen FC, Loebinger MR, Read R, Rohde Get al., 2018, ERS syllabus for postgraduate training in respiratory infections: a guide for comprehensive training, Breathe, Vol: 14, Pages: 269-275, ISSN: 2073-4735

ERS has developed a syllabus for postgraduate training in respiratory infections to guide programme designers http://ow.ly/xJ0R30m8CYB.

Journal article

Finch S, Polverino E, Blasi F, Ringshausen F, De Soyza A, Vendrell M, Goeminne P, Boersma W, Haworth C, Murris-Espin M, Dimakou A, Loebinger M, Menendez R, Torres A, Welte T, Hill A, Wilson R, Elborn S, Aliberti S, Chalmers JDet al., 2018, Sex differences in bronchiectasis patient characteristics: an analysis of the EMBARC cohort, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Shteinberg M, Goeminne P, Loebinger M, Haworth C, Ringshausen F, Dimakou K, Murris M, Vendrell M, Menendez R, Wilson R, Hill A, Torres A, Welte T, Blasi F, De Soyza A, Elborn S, Polverino E, Chalmers J, Aliberti Set al., 2018, Rhinosinusitis is associated with increased symptoms and more frequent exacerbations among patients with bronchiectasis-data from the EMBARC registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Pinto Mendes MA, Finch S, Shoemark A, Polverino E, Blasi F, Ringshausen FC, De Soyza A, Vendrell M, Goeminne PC, Boersma W, Haworth C, Murris M, Dimakou K, Hill AT, Loebinger MR, Menendez R, Torres A, Welte T, Wilson R, Elborn S, Aliberti S, Chalmers Jet al., 2018, Chest Physiotherapy in patients with Bronchiectasis - what is the current practice in Europe?, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Walker P, Herrero B, Spinou A, Dimakou K, Blasi F, Ringshausen F, De Soyza A, Vendrell M, Goeminne PC, Boersma W, Haworth C, Murris M, Hill AT, Loebinger MR, Menendez R, Torres A, Welte T, Wilson R, Elborn JS, Aliberti S, Chalmers JD, Polverino Eet al., 2018, Variability in access and referral to pulmonary rehabilitation in European bronchiectasis patients enrolled in the EMBARC registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Pinto Mendes MA, Finch S, Shoemark A, Polverino E, Blasi F, Ringshausen FC, De Soyza A, Vendrell M, Goeminne PC, Boersma W, Haworth C, Murris M, Dimakou K, Hill AT, Loebinger MR, Menendez R, Torres A, Welte T, Wilson R, Elborn S, Aliberti S, Chalmers JDet al., 2018, Validity of COPD diagnosis in Bronchiectasis patients: data from the EMBARC registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Mcdonnell M, Das J, O'Toole D, Aldrahani A, Verdon B, Wilcox M, Pearson J, Lordan J, De Soyza A, Sousi N, Chalmers J, Laffey J, Loebinger M, Ward C, Rutherford Ret al., 2018, Effects of gastro-oesophageal reflux and pulmonary micro-aspiration in bronchiectasis, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

De Soyza A, Chalmers J, Dimakou K, Hill A, Loebinger M, Menendez R, Blasi F, Ringshausen F, Vendrell M, Goeminne P, Boersma W, Torres A, Welte T, Wilson R, Haworth C, Murris M, Polverino E, Aliberti Set al., 2018, Impact of Inflammatory bowel disease in bronchiectasis (IBD-BR) data from the EMBARC registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Loebinger M, Loebinger M, Ringshausen F, Haworth C, Goeminne P, Murris M, Vendrell M, Menendez R, Wilson R, Boersma W, Hill A, Torres A, Dimakou K, Welte T, De Soyza A, Blasi F, Elborn S, Polverino E, Aliberti S, Chalmers JDet al., 2018, Characteristics of patients with pulmonary non-tuberculous Mycobacterial infection in bronchiectasis: Data from the EMBARC registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Chalmers JD, Polverino E, Blasi F, Ringshausen F, De Soyza A, Vendrell M, Goeminne P, Boersma W, Haworth C, Murris M, Hill A, Loebinger M, Menendez R, Torres A, Dimakou K, Welte T, Wilson R, Elborn S, Aliberti Set al., 2018, The heterogeneity of bronchiectasis patient characteristics, management and outcomes across Europe: Data from the EMBARC registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

O'Neill K, Tunney MM, Angyalosi G, Haworth C, Loebinger MR, Bradley JM, Elborn Set al., 2018, Multiple Breath Washout (MBW) training, certification and quality control during the iBEST-1 trial in bronchiectasis (BE)., 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

O'Neill K, Lakshmipathy GR, Neely C, Cosgrove D, Ferguson K, Chalmers JD, Carroll M, Desoyza A, Gatheral T, Hill AT, Hurst JR, Loebinger MR, Elborn JS, Bradley JMet al., 2018, Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics study., 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Kouis P, Goutaki M, Halbeisen FS, Gioti I, Middleton N, Amirav I, Barbato A, Behan L, Boon M, Emiralioglu N, Haarman E, Karadag B, Koerner-Rettberg C, Lazor R, Loebinger MR, Maitre B, Mazurek H, Morgan L, Nielsen KG, Omran H, Ozcelik U, Price M, Pogorzelski A, Snjiders D, Thouvenin G, Werner C, Zivkovic Z, Kuehni CE, Yiallouros PKet al., 2018, Prevalence and Impact of Lung Resection in Primary Ciliary Dyskinesia: a cohort and nested case-control study, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Shoemark A, Fassad MR, Daudvohra F, Burgoyne T, Hirst RA, Hayes J, Dixon M, Rogers A, Loebinger M, O'Callaghan C, Hogg C, Mitchison Het al., 2018, Motile cilia structure and function in patients with mutations in the outer dynein arm heavy chain DNAH9, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Polverino E, Blasi F, Ringshausen F, De Soyza A, Vendrell M, Goeminne P, Boersma W, Haworth C, Murris M, Dimakou K, Loebinger M, Menendez R, Torres A, Welte T, Wilson R, Elborn S, Aliberti S, Chalmers Jet al., 2018, Determinants of quality of life in bronchiectasis using the quality of life bronchiectasis (QOL-B) questionnaire: data from the EMBARC registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Spinou A, Housley G, Birring SS, Wilson R, Loebinger MRet al., 2018, Cross-sectional comparison of the bronchiectasis-specific quality of life questionnaires, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Shoemark A, Polverino E, Blasi F, Ringshausen FC, De Soyza A, Vendrell M, Goeminne PC, Boersma W, Haworth CS, Murris M, Dimakou K, Hill AT, Loebinger MR, Menendez R, Torres A, Welte T, Wilson R, Elborn S, Alberti S, Chalmers JDet al., 2018, Primary ciliary dyskinesia in adults with bronchiectasis: Data from the Embarc registry, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Loebinger M, Polverino E, Blasi F, Elborn S, Chalmers JD, Tiddens HAWM, Goossens H, Tunney M, Angyalosi G, Hill AT, Haworth Cet al., 2018, A randomised placebo-controlled dose finding study of tobramycin inhalation powder (TIP) in patients with bronchiectasis (BE) and pulmonary P. aeruginosa Pa) infection (iBEST-1), 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Rinaldi G, Dennis B, Houseley G, Shah O, Loebinger Met al., 2018, Utility of drug reaction assessments for inhaled therapies in patients with chronic suppurative lung diseases: results from 5 years of drug reaction assessments, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Griffith DE, Eagle G, Thomson R, Aksamit TR, Hasegawa N, Morimoto K, Addrizzo-Harris DJ, O'Donnell AE, Marras TK, Flume PA, Loebinger MR, Morgan L, Codecasa LR, Hill AT, Ruoss SJ, Yim J-J, Ringshausen FC, Field SK, Philley JV, Wallace RJ, van Ingen J, Coulter C, Nezamis J, Winthrop KL, CONVERT Study Groupet al., 2018, Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT): A Prospective, Open-Label, Randomized Study., Am J Respir Crit Care Med

Rationale Improved therapeutic options are needed for patients with treatment-refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC). Objectives To evaluate the efficacy and safety of daily amikacin liposome inhalation suspension (ALIS) added to standard guideline-based therapy (GBT) in patients with refractory MAC lung disease. Methods Adults with amikacin-susceptible MAC lung disease and MAC-positive sputum cultures despite ≥6 months of stable GBT were randomly assigned (2:1) to receive ALIS with GBT (ALIS+GBT) or GBT alone. Once-daily ALIS was supplied in single-use vials delivering 590 mg amikacin to the nebulizer. The primary endpoint was culture conversion, defined as 3 consecutive monthly MAC-negative sputum cultures by month 6. Measurements and Main Results Enrolled patients (ALIS+GBT, n=224; GBT-alone, n=112) were a mean 64.7 years old and 69.3% female. Most had underlying bronchiectasis (62.5%), chronic obstructive pulmonary disease (14.3%), or both (11.9%). Culture conversion was achieved by 65 of 224 patients (29.0%) with ALIS+GBT and 10 of 112 (8.9%) with GBT alone (OR, 4.22; 95% CI [2.08, 8.57]; P<0.001). Patients in the ALIS+GBT arm vs GBT alone were more likely to achieve conversion (hazard ratio, 3.90; 95% CI, [2.00, 7.60]). Respiratory adverse events (primarily dysphonia, cough, and dyspnea) were reported in 87.4% of patients receiving ALIS+GBT and 50.0% receiving GBT alone; serious treatment-emergent adverse events occurred in 20.2% and 17.9% of patients, respectively. Conclusions Addition of ALIS to GBT for treatment-refractory MAC lung disease achieved significantly greater culture conversion by month 6 than GBT alone, with comparable rates of serious adverse events. Clinical trial registration available at www.clinicaltrials.gov, ID NCT02344004.

Journal article

Goring SM, Wilson JB, Risebrough NR, Gallagher J, Carroll S, Heap KJ, Obradovic M, Loebinger MR, Diel Ret al., 2018, The cost of Mycobacterium avium complex lung disease in Canada, France, Germany, and the United Kingdom: a nationally representative observational study, BMC Health Services Research, Vol: 18, ISSN: 1472-6963

BackgroundManagement of nontuberculous mycobacterial lung disease (NTMLD) consists of a long-term multi-drug antibiotic regimen, yet many patients do not achieve culture conversion. We estimated the NTMLD-related direct medical costs in Canada, France, Germany, and the United Kingdom (UK) among refractory patients who were infected with Mycobacterium avium complex (MAC), without concomitant cystic fibrosis, tuberculosis, or HIV.MethodsWe conducted a retrospective observational physician survey of nationally representative samples. The survey captured anonymized information about patients’ treatment histories for NTMLD-related health care resource utilization over a 24-month period. We summarized NTMLD-related resource use and estimated the total economic burden, from each country’s health care payer perspective.ResultsIn total, 59 physicians provided data on 157 patients. The average person time observed during the 24-month period was 1.7 years (SD: 0.4); 17% of patients died by the end of the study period. The major components of NTMLD-related direct medical costs among refractory patients were hospitalizations (varying from 29% of total annual costs in the UK to 69% in France), outpatient visits (8% in Canada to 51% in the UK), and outpatient testing such as post-diagnostic sputum testing, bronchial wash/lavage, spirometry, biopsies, imaging, and electrocardiograms (5% in France to 35% in Canada). In this patient cohort, the average direct medical costs per person-year, in local currencies, were approximately $16,200 (Canada), €11,600 (Germany), €17,900 (France) and £9,700 (UK).ConclusionsBased on this study’s findings, we conclude that managing patients with refractory NTMLD caused by MAC is associated with a substantial economic burden.

Journal article

Cowman SA, Jacob J, Obaidee S, Floto RA, Wilson R, Haworth CS, Loebinger MRet al., 2018, Latent class analysis to define radiological subgroups in pulmonary nontuberculous mycobacterial disease, BMC Pulmonary Medicine, Vol: 18, ISSN: 1471-2466

BackgroundNontuberculous mycobacterial (NTM) pulmonary disease has conventionally been classified on the basis of radiology into fibrocavitary and nodular-bronchiectatic disease. Whilst being of great clinical utility, this may not capture the full spectrum of radiological appearances present. The aim of this study was to use latent class analysis (LCA) as an unbiased method of grouping subjects with NTM-pulmonary disease based on their CT features and to compare the clinical characteristics of these groups.MethodsIndividuals with NTM-pulmonary disease were recruited and a contemporaneous CT scan obtained. This was scored using an NTM-specific scoring system. LCA was used to identify groups with common radiological characteristics. The analysis was then repeated in an independent cohort.ResultsThree classes were identified in the initial cohort of 85 subjects. Group 1 was characterised by severe bronchiectasis, cavitation and aspergillomas, Group 2 by relatively minor radiological changes, and Group 3 by predominantly bronchiectasis only. These findings were reproduced in an independent cohort of 62 subjects. Subjects in Group 1 had a lower BMI and serum albumin, higher serum CRP, and a higher mortality.ConclusionsThese findings suggest that NTM-pulmonary may be divided into three radiological subgroups, and that important clinical and survival differences exist between these groups.

Journal article

Aliberti S, Codecasa LR, Gori A, Sotgiu G, Spotti M, Di Biagio A, Calcagno A, Nardini S, Assael BM, Tortoli E, Besozzi G, Ferrarese M, Matteelli A, Girardi E, De Lorenzo S, Seia M, Gramegna A, Del Prato B, Terranova L, Oriano M, Sverzellati N, Mirsaeidi M, Chalmers JD, Haworth CS, Loebinger MR, Aksamit T, Winthrop K, Ringshausen FC, Previdi G, Blasi Fet al., 2018, The Italian registry of pulmonary non-tuberculous mycobacteria - IRENE: the study protocol, MULTIDISCIPLINARY RESPIRATORY MEDICINE, Vol: 13, ISSN: 2049-6958

Journal article

Halbeisen FS, Goutaki M, Spycher BD, Amirav I, Behan L, Boon M, Hogg C, Casaulta C, Crowley S, Haarman EG, Karadag B, Koerner-Rettberg C, Loebinger MR, Mazurek H, Morgan L, Nielsen KG, Omran H, Santamaria F, Schwerk N, Thouvenin G, Yiallouros P, Lucas JS, Latzin P, Kuehni CEet al., 2018, Lung function in patients with primary ciliary dyskinesia: an iPCD Cohort study, EUROPEAN RESPIRATORY JOURNAL, Vol: 52, ISSN: 0903-1936

Journal article

McDonnell MJ, O'Toole D, Ward C, Pearson JP, Lordan JL, De Soyza A, Loebinger M, Chalmers JD, Laffey JG, Rutherford RMet al., 2018, A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk, RESPIRATORY MEDICINE, Vol: 141, Pages: 132-143, ISSN: 0954-6111

Journal article

Goeminne PC, Cox B, Finch S, Loebinger MR, Bedi P, Hill AT, Fardon TC, de Hoogh K, Nawrot TS, Chalmers JDet al., 2018, The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis, EUROPEAN RESPIRATORY JOURNAL, Vol: 52, ISSN: 0903-1936

Journal article

Cowman SA, Loebinger MR, 2018, Reply to: Reduced IFN-γ in Patients with Pulmonary Nontuberculous Mycobacterial Disease: Potentially Multiple Causes, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 59, Pages: 131-131, ISSN: 1044-1549

Journal article

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