Publications
259 results found
Cowman S, Loebinger M, 2015, Nontuberculous mycobacterial pulmonary disease, Clinical Pulmonary Medicine, Vol: 22, Pages: 8-14, ISSN: 1068-0640
Nontuberculous mycobacteria (NTM) are a group of ubiquitous environmental organisms which may cause infection in humans, most commonly pulmonary disease. Most individuals with disease have an underlying structural lung disease such as bronchiectasis or chronic obstructive pulmonary disease; however, individuals with no known risk factors may also develop disease; the reason for this is unknown. NTM are frequent contaminants of clinical samples, and diagnosis does not rest upon culture alone, but also clinical and radiographic findings. The clinical course of patients with NTM is variable, patients may remain stable without treatment and the decision to treat may not be straightforward. Treatment for NTM varies between species but is usually with multiple antimycobacterial agents for a prolonged period of time; surgery may also be employed in selected cases. Drug intolerance is common and outcomes for many species are inferior to those seen in tuberculosis. The prognosis of NTM infection is poor, although this may also reflect the poor underlying health of the affected patients. There is a need for the development of better treatment regimens and for research aimed at understanding the mechanisms leading to disease susceptibility and progression.
Cox MJ, Turek EM, Mirza GK, et al., 2015, Longitudinal Analysis Of The Non-Cystic Fibrosis Bronchiectasis Microbiome, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Jones A, Simmonds N, Gyi KM, et al., 2015, Clinical Differences In Mycobacterium Abscessus Subspecies Infection In Cystic Fibrosis Patients, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Spinou A, Garrod R, Lee KK, et al., 2014, OBJECTIVE COUGH FREQUENCY MONITORING IN BRONCHIECTASIS, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A80-A81, ISSN: 0040-6376
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- Citations: 2
Bilton D, Loebinger MR, Wilson R, 2014, Non-cystic fibrosis bronchiectasis: an evidence-base for new therapies, LANCET RESPIRATORY MEDICINE, Vol: 2, Pages: 958-960, ISSN: 2213-2600
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- Citations: 6
CFelton I, Benson I, Nicholson A, et al., 2014, PRELIMINARY EVALUATION OF THE FUNGAL AIRWAY MICROBIOME IN ADULT CYSTIC FIBROSIS BY NEXT-GENERATION SEQUENCING, CULTURE AND STAINING TECHNIQUES, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A164-A164, ISSN: 0040-6376
Woodfield G, Passey-Heaton B, Chakrabarti A, et al., 2014, An evaluation of the use of a negative interferon-γ release assay for tuberculosis screening before INF antagonist therapy, EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 1369-1372, ISSN: 0903-1936
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- Citations: 3
Schuetz K, Grimbacher B, Haddock J, et al., 2014, A Multicentre Approach to Document Bronchial Pathology in Computed Tomography of the Chest: Data from the Chest CT in Antibody-Deficiency Group, 16th Biennial Meeting of the European-Society-for-Immunodeficiencies, Publisher: SPRINGER/PLENUM PUBLISHERS, Pages: S323-S324, ISSN: 0271-9142
Grillo LJF, Irving S, Davies JC, et al., 2014, The reproducibility and responsiveness of the lung clearance index (LCI) in bronchiectasis, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Fernandes M, Gatheral T, Dhunnookchand R, et al., 2014, Aminoglycoside use for pseudomonas aeruginosa in bronchiectasis, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Char A, Hopkinson NS, Hansell DM, et al., 2014, Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: a cohort study, BMC PULMONARY MEDICINE, Vol: 14, ISSN: 1471-2466
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- Citations: 22
Zoumot Z, Boutou AK, Gill SS, et al., 2014, Mycobacterium avium complex infection in non-cystic fibrosis bronchiectasis, RESPIROLOGY, Vol: 19, Pages: 714-722, ISSN: 1323-7799
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- Citations: 51
Doering G, Bragonzi A, Paroni M, et al., 2014, BIIL 284 reduces neutrophil numbers but increases <i>P-aeruginosa</i> bacteremia and inflammation in mouse lungs, JOURNAL OF CYSTIC FIBROSIS, Vol: 13, Pages: 156-163, ISSN: 1569-1993
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- Citations: 54
Keir GJ, Garfield B, Hansell DM, et al., 2014, Cyclical caspofungin for chronic pulmonary aspergillosis in sarcoidosis, THORAX, Vol: 69, Pages: 287-U93, ISSN: 0040-6376
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- Citations: 24
Shah A, Rogers A, Shoemark A, et al., 2013, A RETROSPECTIVE STUDY CHARACTERISING CILIARY ULTRASTRUCTURE, LIGHT MICROSCOPY AND SPUTUM MICROBIOLOGY ASSOCIATIONS WITH LUNG FUNCTION DECLINE IN A LARGE ADULT PRIMARY CILIARY DYSKINESIA COHORT, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A65-A65, ISSN: 0040-6376
Adams L, Loebinger M, Shoemark A, 2013, A ROLE FOR POLYCYSTINS IN AIRWAY MUCOCILIARY CLEARANCE?, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A185-A185, ISSN: 0040-6376
Cowman S, Goward C, Bilton D, et al., 2013, Species differences in NTM pulmonary disease (pNTM), EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Cowman S, Goward C, Bilton D, et al., 2013, Pulmonary non-tuberculous mycobacterial infection (pNTM) with multiple species, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
De Soyza A, Brown JS, Loebinger MR, 2013, Research priorities in bronchiectasis, THORAX, Vol: 68, Pages: 695-696, ISSN: 0040-6376
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- Citations: 31
Wilson R, Hansell DM, Loebinger MR, 2013, Definition and aetiology of non-CF bronchiectasis, SPECTRUM OF BRONCHIAL INFECTION, Editors: Blasi, Miravitlles, Welte, Publisher: EUROPEAN RESPIRATORY SOCIETY, Pages: 107-119, ISBN: 978-1-84984-034-7
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- Citations: 4
Coleman MC, Hennessy C, Bilton D, et al., 2012, THE SHORT TERM VARIABILITY OF SPUTUM MICROBIOLOGY IN NON-CF BRONCHIECTASIS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A139-A139, ISSN: 0040-6376
Garfield B, Keir G, Anwar M, et al., 2012, Caspofungin to treat invasive pulmonary aspergillosis in sarcoidosis, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Metcalf R, Clark SA, Graeme C, et al., 2012, Correlates of immune protection in <i>Mycobacterium tuberculosis</i>, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 596-597, ISSN: 0019-2805
Patterson CM, Loebinger MR, 2012, Community acquired pneumonia: assessment and treatment, CLINICAL MEDICINE, Vol: 12, Pages: 283-286, ISSN: 1470-2118
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- Citations: 9
Cowman S, Wilson R, Loebinger MR, 2012, Opportunistic mycobacterial diseases, Medicine (United Kingdom), Vol: 40, Pages: 346-348, ISSN: 1357-3039
Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that may cause a variety of infections including pulmonary disease, the prevalence of which is increasing. Whilst patients with immunodeficiency or chronic lung disease are most often affected, individuals with no apparent underlying predisposition may also develop infection. The most common species causing pulmonary disease in the UK are Mycobacterium avium complex (MAC), Mycobacterium kansasii, Mycobacterium xenopi and Mycobacterium malmoense. Their ubiquitous nature makes them frequent contaminants and the diagnosis of pulmonary disease requires firm evidence of infection with supportive clinical and radiological features. The management of NTM pulmonary disease is challenging as patients may remain stable for prolonged periods and treatment may be poorly tolerated. Treatment varies between species, but involves prolonged courses of a combination of antibiotics. NTM are often drug resistant and surgery may be considered in selected cases. Treatment outcomes are inferior to tuberculosis and in some cases a cure may not be attainable. © 2012 Elsevier Ltd. All rights reserved.
Cox MJ, Jones AL, Loebinger MR, et al., 2011, MUCOIDY AND THE MICROBIOME: COMMUNITY COMPOSITION IN RELATION TO THE PRESENCE OF CULTURABLE, MUCOID <i>PSEUDOMONAS AERUGINOSA</i>, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A24-A24, ISSN: 0040-6376
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- Citations: 2
Devaraj A, Wells AU, Meister MG, et al., 2011, Pulmonary Hypertension in Patients With Bronchiectasis: Prognostic Significance of CT Signs, AMERICAN JOURNAL OF ROENTGENOLOGY, Vol: 196, Pages: 1300-1304, ISSN: 0361-803X
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- Citations: 39
Ford T, Clark SA, Pantelidis P, et al., 2010, IL18R upregulation used in a clinical laboratory approach to identify IFN-γ/IL12 defects in Mendalian Susceptibility to Mycobacterial Disease (MSDM), Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 137-137, ISSN: 0019-2805
Hart M, Page E, Ford T, et al., 2010, Increases in CD21<SUP>low</SUP> B cells are significantly associated with levels of circulating TNF family chemokines BAFF and APRIL in CVID patients, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 96-96, ISSN: 0019-2805
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- Citations: 1
Loebinger MR, Sage EK, Davies D, et al., 2010, TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population, BRITISH JOURNAL OF CANCER, Vol: 103, Pages: 1692-1697, ISSN: 0007-0920
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- Citations: 70
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