Summary
Dr Marie Loh is a Research Associate at the Department of Epidemiology and Biostatistics of the School of Public Health with the London Life Sciences Population (LOLIPOP) team (PIs: Dr John Chambers and Prof Jaspal Kooner). Prior to joining the department, she was a Visiting Researcher here, and a Senior Research Fellow at the University of Oulu.
Dr Loh holds a basic degree (BSc) in Statistics, as well as a Masters in Bioinformatics and a Masters in Statistics. She subsequently obtained her PhD from the University of Western Australin in Perth, Australia while working as a Research Fellow at the Cancer Science Institute of Singapore. Her PhD work was focused on genetic variations between East Asians and Caucasians that influence risk and chemotherapeutic outcomes in gastrointestinal cancers.
Dr Loh specializes in the analysis of high-throughput omics data, next generation sequencing and meta-analyses of both genetics and clinical trial data. Her research focuses on mechanisms underlying non-communicable diseases such as cardiovascular diseases and cancer, with a specific interest in transethnic studies.
Selected Publications
Journal Articles
Chambers JC, Abbott J, Zhang W, et al., 2014, The South Asian Genome, PLOS One, Vol:9, ISSN:1932-6203
Loh M, Liem N, Vaithilingam A, et al., 2014, DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach., Bmc Gastroenterol, Vol:14
Subramaniam MM, Loh M, Chan JY, et al., 2014, The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers., Mol Carcinog, Vol:53, Pages:98-108
Loh M, Chua D, Yao Y, et al., 2013, Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequencies?, Pharmacogenomics J, Vol:13, Pages:423-429
Soo RA, Kawaguchi T, Loh M, et al., 2012, Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy., Future Oncol, Vol:8, Pages:451-462
Sapari NS, Loh M, Vaithilingam A, et al., 2012, Clinical potential of DNA methylation in gastric cancer: a meta-analysis., Plos One, Vol:7
Loh M, Soong R, 2011, Challenges and pitfalls in the introduction of pharmacogenetics for cancer., Annals Academy of Medicine Singapore, Vol:40, ISSN:0304-4602, Pages:369-374
Soo RA, Loh M, Mok TS, et al., 2011, Ethnic differences in survival outcome in patients with advanced stage non-small cell lung cancer: results of a meta-analysis of randomized controlled trials., J Thorac Oncol, Vol:6, Pages:1030-1038
Loh M, Liem N, Lim PL, et al., 2010, Impact of sample heterogeneity on methylation analysis., Diagn Mol Pathol, Vol:19, Pages:243-247
Ang PW, Loh M, Liem N, et al., 2010, Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features, BMC Cancer, Vol:10, ISSN:1471-2407
Loh M, Koh KX, Yeo BH, et al., 2009, Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race., Eur J Cancer, Vol:45, Pages:2562-2568
Wong W-C, Loh M, Eisenhaber F, 2008, On the necessity of different statistical treatment for Illumina BeadChip and Affymetrix GeneChip data and its significance for biological interpretation., Biol Direct, Vol:3