Imperial College London
Alternate

DrMarieLoh

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2885m.loh

 
 
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Location

 

172Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Soo:2012:10.2217/fon.12.25,
author = {Soo, RA and Kawaguchi, T and Loh, M and Ou, S-HI and Shieh, MP and Cho, B-C and Mok, TS and Soong, R},
doi = {10.2217/fon.12.25},
journal = {Future Oncol},
pages = {451--462},
title = {Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy.},
url = {http://dx.doi.org/10.2217/fon.12.25},
volume = {8},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It is increasingly recognized that differences in overall survival and toxicity exist between Asian and caucasian patients with small-cell and non-small-cell lung cancer, with a longer survival, higher response rates and greater toxicity to chemotherapy and targeted therapy reported in Asian patients. Two global studies are used to illustrate how the proportions of Asian patients can influence survival outcome. Ethnicity is an important and complex characteristic that should considered in the design and conduct of a global clinical study, as the safety, tolerability and response may vary between Asian and caucasian patients. Whether ethnic differences in lung cancer survival are attributed to genetic differences among races or are simply a surrogate marker of differences in access to healthcare because of socioeconomic differences is unclear. Carefully designed prospective studies investigating ethnic-specific determinants of sensitivity and toxicity to systemic therapy are warranted.
AU  - Soo,RA
AU  - Kawaguchi,T
AU  - Loh,M
AU  - Ou,S-HI
AU  - Shieh,MP
AU  - Cho,B-C
AU  - Mok,TS
AU  - Soong,R
DO  - 10.2217/fon.12.25
EP  - 462
PY  - 2012///
SP  - 451
TI  - Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy.
T2  - Future Oncol
UR  - http://dx.doi.org/10.2217/fon.12.25
UR  - https://www.ncbi.nlm.nih.gov/pubmed/22515448
VL  - 8
ER  -
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