Imperial College London
Alternate

DrMarieLoh

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2885m.loh

 
 
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Location

 

172Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wen:2012:10.7314/apjcp.2012.13.5.2139,
author = {Wen, Y-Y and Pan, X-F and Loh, M and Tian, Z and Yang, S-J and Lv, S-H and Huang, W-Z and Huang, H and Xie, Y and Soong, R and Yang, C-X},
doi = {10.7314/apjcp.2012.13.5.2139},
journal = {Asian Pac J Cancer Prev},
pages = {2139--2144},
title = {ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China.},
url = {http://dx.doi.org/10.7314/apjcp.2012.13.5.2139},
volume = {13},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. METHODS: We designed a multicenter 1:1 matched case- control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. RESULTS: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P<0.05). CONCLUSIONS: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findings may offer insight into further similar large gene-environment and gene-gene studies in this region.
AU  - Wen,Y-Y
AU  - Pan,X-F
AU  - Loh,M
AU  - Tian,Z
AU  - Yang,S-J
AU  - Lv,S-H
AU  - Huang,W-Z
AU  - Huang,H
AU  - Xie,Y
AU  - Soong,R
AU  - Yang,C-X
DO  - 10.7314/apjcp.2012.13.5.2139
EP  - 2144
PY  - 2012///
SP  - 2139
TI  - ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China.
T2  - Asian Pac J Cancer Prev
UR  - http://dx.doi.org/10.7314/apjcp.2012.13.5.2139
UR  - https://www.ncbi.nlm.nih.gov/pubmed/22901183
VL  - 13
ER  -
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