Imperial College London
Alternate

DrMarieLoh

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2885m.loh

 
 
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Location

 

172Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chong:2014:10.1002/ijc.28444,
author = {Chong, M-L and Loh, M and Thakkar, B and Pang, B and Iacopetta, B and Soong, R},
doi = {10.1002/ijc.28444},
journal = {Int J Cancer},
pages = {1232--1238},
title = {Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation.},
url = {http://dx.doi.org/10.1002/ijc.28444},
volume = {134},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Inhibition of the phosphatidylinositol-3-kinase (PI3K) signaling pathway is a cancer treatment strategy that has entered into clinical trials. We performed a meta-analysis on the frequency of prominent genetic (PIK3CA mutation, PIK3CA amplification and PTEN deletion) and protein expression (high PI3K, PTEN loss and high pAkt) aberrations in the PI3K pathway in gastric cancer (GC) and colorectal cancer (CRC). We also performed laboratory analysis to investigate the co-occurrence of these aberrations. The meta-analysis indicated that East Asian and Caucasian GC patients differ significantly for the frequencies of PIK3CA Exon 9 and 20 mutations (7% vs. 15%, respectively), PTEN deletion (21% vs. 4%) and PTEN loss (47% vs. 78%), while CRC patients differed for PTEN loss (57% vs. 26%). High study heterogeneity (I(2) > 80) was observed for all aberrations except PIK3CA mutations. Laboratory analysis of tumors from East Asian patients revealed significant differences between GC (n = 79) and CRC (n = 116) for the frequencies of PIK3CA amplification (46% vs. 4%) and PTEN loss (54% vs. 78%). The incidence of GC cases with 0, 1, 2 and 3 concurrent aberrations was 14%, 52%, 27% and 8%, respectively, while for CRC it was 10%, 60%, 25% and 4%, respectively. Our study consolidates knowledge on the frequency, co-occurrence and clinical relevance of PI3K pathway aberrations in GC and CRC. Up to 86% of GC and 90% of CRC have at least one aberration in the PI3K pathway, and there are significant differences in the frequencies of these aberrations according to cancer type and ethnicity.
AU  - Chong,M-L
AU  - Loh,M
AU  - Thakkar,B
AU  - Pang,B
AU  - Iacopetta,B
AU  - Soong,R
DO  - 10.1002/ijc.28444
EP  - 1238
PY  - 2014///
SP  - 1232
TI  - Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation.
T2  - Int J Cancer
UR  - http://dx.doi.org/10.1002/ijc.28444
UR  - https://www.ncbi.nlm.nih.gov/pubmed/23960014
VL  - 134
ER  -
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