Publications

BibTex format

@article{Wen:2014:10.1097/CEJ.0b013e3283656380,
author = {Wen, Y-Y and Pan, X-F and Loh, M and Yang, S-J and Xie, Y and Tian, Z and Huang, H and Lan, H and Chen, F and Soong, R and Yang, C-X},
doi = {10.1097/CEJ.0b013e3283656380},
journal = {Eur J Cancer Prev},
pages = {35--42},
title = {Association of the IL-1B +3954 C/T polymorphism with the risk of gastric cancer in a population in Western China.},
url = {http://dx.doi.org/10.1097/CEJ.0b013e3283656380},
volume = {23},
year = {2014}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - With an estimate of 380 000 new cases each year, gastric cancer (GC) is one of the most frequently occurring cancers in China. Genes encoding proinflammatory and anti-inflammatory cytokines are good candidates for the study of susceptibility to GC. We tested the hypothesis that the polymorphisms of interleukin 1B (IL-1B) and IL-1RN contribute toward host susceptibility to GC. In a matched case-control design, we enrolled 308 pairs of GC and control participants between October 2010 and August 2011. We sequenced IL-1B +3954 C/T, IL-1RN -9876 G/A, -9739 A/G, and IL-1RN -9091 A/C using MALDI-TOF MS and collected demographic data as well as lifestyle factors using a questionnaire. GC patients reported statistically significantly greater proportions with family history of cancer (29.9 vs. 10.7%, P<0.01) and alcohol drinking (54.5 vs. 43.2%, P<0.01) than the controls. The proportion of irregular eaters was statistically higher among the patients than among the controls (66.7 vs. 24.4%, P<0.01). The IL-1B +3954 CT or the TT variant genotype was statistically significantly associated with a risk of GC [adjusted odds ratio (OR), 2.94; 95% confidence interval (CI), 1.06-8.15], whereas variants of IL-1RN -9876 G/A, IL-1RN -9739 A/G, and IL-1RN -9091 A/C were not associated (adjusted OR, 1.29, 95% CI, 0.77-2.16; adjusted OR, 1.25, 95% CI, 0.75-2.07; adjusted OR, 1.09, 95% CI, 0.71-1.67, respectively). Haplotypes established from the three polymorphisms of IL-1RN were not associated with a risk of GC. The IL-1B +3954 C/T polymorphism is associated with a risk of GC in our study. Lifestyle and environmental factors such as drinking, eating irregularly, and family history of cancer increase the risk.
AU  - Wen,Y-Y
AU  - Pan,X-F
AU  - Loh,M
AU  - Yang,S-J
AU  - Xie,Y
AU  - Tian,Z
AU  - Huang,H
AU  - Lan,H
AU  - Chen,F
AU  - Soong,R
AU  - Yang,C-X
DO  - 10.1097/CEJ.0b013e3283656380
EP  - 42
PY  - 2014///
SP  - 35
TI  - Association of the IL-1B +3954 C/T polymorphism with the risk of gastric cancer in a population in Western China.
T2  - Eur J Cancer Prev
UR  - http://dx.doi.org/10.1097/CEJ.0b013e3283656380
UR  - https://www.ncbi.nlm.nih.gov/pubmed/24080970
VL  - 23
ER  -

Download

DrMarieLoh

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)