Imperial College London
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Dr Mark P. Lythgoe

Faculty of Medicine, Department of Surgery & Cancer

Research Postgraduate
 
 
 
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Contact

 

m.lythgoe

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Benjamin:2022:10.1200/jco.2022.40.6_suppl.574,
author = {Benjamin, DJ and Lythgoe, M and Raymakers, AJN and Rezazadeh, A},
doi = {10.1200/jco.2022.40.6_suppl.574},
journal = {Journal of Clinical Oncology},
pages = {574--574},
title = {Cost effectiveness of newly approved second/third-line agents in metastatic urothelial carcinoma (mUC).},
url = {http://dx.doi.org/10.1200/jco.2022.40.6_suppl.574},
volume = {40},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p> 574 </jats:p><jats:p> Background: Over the past years, the treatment landscape of platinum-refractory mUC has drastically changed with the advent of immunotherapy. More recently, several new agents including enfortumab, erdafitinib, and sacituzumab have received F.D.A. approval for the treatment of platinum-refractory mUC. It is unclear if these newly approved therapies may be cost prohibitive for patients and/or hospitals/clinics compared to the recommended NCCN category 1 second-line agent, pembrolizumab. Methods: Using acquisition costs from our home institution’s cancer center pharmacy department, we calculated the total cost of treatment for each agent. We used phase II clinical trial data to determine the median duration of treatment for each therapy. For weight-based therapies, we used 70 kg as the weight for an average human adult. Results: The three newly approved therapies for mUC have total acquisition costs in descending order as follows: enfortumab vedotin ($153,697.50), edafitinib ($131,642.62), and sacituzumab govitecan ($63,198.07). Enfortumab and sacituzumab likely have higher total costs given both therapies require infusion center use for administration, and are associated with infusion center administration fees. In comparison, pembrolizumab (standard of care per NCCN guidelines) has a total acquisition cost of $51,343.60. Conclusions: Based off median duration of treatment, pembrolizumab has the lowest total acquisition cost compared to the three newly approved therapies for mUC. Further statistical analysis of this data set is ongoing. In particular, analysis will include out-of-pocket costs for patients as well as quality-adjusted life years (QALY).[Table: see text] </jats:p>
AU  - Benjamin,DJ
AU  - Lythgoe,M
AU  - Raymakers,AJN
AU  - Rezazadeh,A
DO  - 10.1200/jco.2022.40.6_suppl.574
EP  - 574
PY  - 2022///
SN  - 0732-183X
SP  - 574
TI  - Cost effectiveness of newly approved second/third-line agents in metastatic urothelial carcinoma (mUC).
T2  - Journal of Clinical Oncology
UR  - http://dx.doi.org/10.1200/jco.2022.40.6_suppl.574
VL  - 40
ER  -
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