Imperial College London
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Dr Mark P. Lythgoe

Faculty of Medicine, Department of Surgery & Cancer

Research Postgraduate
 
 
 
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Contact

 

m.lythgoe

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mirón-Barroso:2022:10.3390/ncrna8040058,
author = {Mirón-Barroso, S and Correia, JS and Frampton, AE and Lythgoe, MP and Clark, J and Tookman, L and Ottaviani, S and Castellano, L and Porter, AE and Georgiou, TK and Krell, J},
doi = {10.3390/ncrna8040058},
journal = {Non-Coding RNA},
pages = {58--58},
title = {Polymeric carriers for delivery of RNA cancer therapeutics},
url = {http://dx.doi.org/10.3390/ncrna8040058},
volume = {8},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - As research uncovers the underpinnings of cancer biology, new targeted therapies have been developed. Many of these therapies are small molecules, such as kinase inhibitors, that target specific proteins; however, only 1% of the genome encodes for proteins and only a subset of these proteins has ‘druggable’ active binding sites. In recent decades, RNA therapeutics have gained popularity due to their ability to affect targets that small molecules cannot. Additionally, they can be manufactured more rapidly and cost-effectively than small molecules or recombinant proteins. RNA therapeutics can be synthesised chemically and altered quickly, which can enable a more personalised approach to cancer treatment. Even though a wide range of RNA therapeutics are being developed for various indications in the oncology setting, none has reached the clinic to date. One of the main reasons for this is attributed to the lack of safe and effective delivery systems for this type of therapeutic. This review focuses on current strategies to overcome these challenges and enable the clinical utility of these novel therapeutic agents in the cancer clinic.
AU  - Mirón-Barroso,S
AU  - Correia,JS
AU  - Frampton,AE
AU  - Lythgoe,MP
AU  - Clark,J
AU  - Tookman,L
AU  - Ottaviani,S
AU  - Castellano,L
AU  - Porter,AE
AU  - Georgiou,TK
AU  - Krell,J
DO  - 10.3390/ncrna8040058
EP  - 58
PY  - 2022///
SN  - 2311-553X
SP  - 58
TI  - Polymeric carriers for delivery of RNA cancer therapeutics
T2  - Non-Coding RNA
UR  - http://dx.doi.org/10.3390/ncrna8040058
UR  - http://hdl.handle.net/10044/1/99089
VL  - 8
ER  -
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