Publications
38 results found
Butnariu A-B, Look A, Grillo M, et al., 2021, SARS-CoV-2-host cell surface interactions and potential antiviral therapies, Interface Focus, Vol: 12, Pages: 1-9, ISSN: 2042-8901
In this review, we reveal the latest developments at the interface between SARS-CoV-2 and the host cell surface. In particular, we evaluate the current and potential mechanisms of binding, fusion and the conformational changes of the spike (S) protein to host cell surface receptors, especially the human angiotensin-converting enzyme 2 (ACE2) receptor. For instance, upon the initial attachment, the receptor binding domain of the S protein forms primarily hydrogen bonds with the protease domain of ACE2 resulting in conformational changes within the secondary structure. These surface interactions are of paramount importance and have been therapeutically exploited for antiviral design, such as monoclonal antibodies. Additionally, we provide an insight into novel therapies that target viral non-structural proteins, such as viral RNA polymerase. An example of which is remdesivir which has now been approved for use in COVID-19 patients by the US Food and Drug Administration. Establishing further understanding of the molecular details at the cell surface will undoubtably aid the development of more efficacious and selectively targeted therapies to reduce the burden of COVID-19.
Janahi EM, McGarvey MJ, 2013, The inhibition of hepatitis B virus by APOBEC cytidine deaminases, JOURNAL OF VIRAL HEPATITIS, Vol: 20, Pages: 821-828, ISSN: 1352-0504
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- Citations: 40
Blackham SL, McGarvey MJ, 2013, A host cell RNA-binding protein, Staufen1, has a role in hepatitis C virus replication before virus assembly, JOURNAL OF GENERAL VIROLOGY, Vol: 94, Pages: 2429-2436, ISSN: 0022-1317
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- Citations: 17
Blackham S, Baillie A, Al-Hababi F, et al., 2010, Gene Expression Profiling Indicates the Roles of Host Oxidative Stress, Apoptosis, Lipid Metabolism, and Intracellular Transport Genes in the Replication of Hepatitis C Virus, JOURNAL OF VIROLOGY, Vol: 84, Pages: 5404-5414, ISSN: 0022-538X
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- Citations: 111
McGarvey MJ, Iqbal M, Nastos T, et al., 2008, Restricted quasispecies variation following infection with the GB virus B, VIRUS RESEARCH, Vol: 135, Pages: 181-186, ISSN: 0168-1702
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- Citations: 5
Mohammed E, Navaratnam N, Hoare JM, et al., 2006, The effects of APOBEC3G on HBV replication, 12th International Symposium on Viral Hepatitis and Liver Disease, Publisher: ELSEVIER SCIENCE BV, Pages: S67-S67, ISSN: 1386-6532
Keasler VV, Lerat H, Madden CR, et al., 2006, Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein, VIROLOGY, Vol: 347, Pages: 466-475, ISSN: 0042-6822
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- Citations: 31
Moore MD, McGarvey MJ, Russell RA, et al., 2005, Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors, JOURNAL OF GENE MEDICINE, Vol: 7, Pages: 918-925, ISSN: 1099-498X
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- Citations: 52
Hoare J, Waddington S, Thomas HC, et al., 2005, Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice, JOURNAL OF GENE MEDICINE, Vol: 7, Pages: 325-333, ISSN: 1099-498X
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- Citations: 38
McGarvey MJ, Houghton M, 2005, Hepatitis C Virus: Structure and Molecular Virology, Viral Hepatitis, Editors: Thomas, Lemon, Zuckerman, Malden, Massachusetts, Publisher: Blackwell Publishing Inc., Pages: 381-406, ISBN: 978-1-4051-3005-9
Caronia S, McGarvey MJ, Goldin RD, et al., 2004, Negative correlation between intrahepatic expression of hepatitis C antigens and apoptosis despite high-level expression of Fas and HLA antigens, JOURNAL OF VIRAL HEPATITIS, Vol: 11, Pages: 511-518, ISSN: 1352-0504
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- Citations: 4
Gallivan JP, McGarvey MJ, 2003, The importance of the Q motif in the ATPase activity of a viral helicase, FEBS LETTERS, Vol: 554, Pages: 485-488, ISSN: 0014-5793
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- Citations: 12
Moore MD, McGarvey MJ, McClure MO, 2003, RNA interference of HBV gene expression, Molecular Therapy, Vol: 7, Pages: S30-S30
Hoare J, Henkler F, Dowling JJ, et al., 2001, Subcellular localisation of the X protein in HBV infected hepatocytes, JOURNAL OF MEDICAL VIROLOGY, Vol: 64, Pages: 419-426, ISSN: 0146-6615
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- Citations: 44
Hoare J, Botto M, Thomas HC, et al., 2001, The inactivation of baculovirus vectors by the innate immune system, JOURNAL OF HEPATOLOGY, Vol: 34, Pages: 222-222, ISSN: 0168-8278
Henkler F, Hoare J, Waseem N, et al., 2001, Intracellular localization of the hepatitis B virus HBx protein, JOURNAL OF GENERAL VIROLOGY, Vol: 82, Pages: 871-882, ISSN: 0022-1317
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- Citations: 125
Hoare JM, Henkler F, Robert GD, et al., 2000, The subcellular localisation of the X protein in HBV infected hepatocytes., HEPATOLOGY, Vol: 32, Pages: 448A-448A, ISSN: 0270-9139
Caronia S, Gulati V, McGarvey MJ, et al., 2000, Hepatitis C virus infected hepatocytes and apoptosis., HEPATOLOGY, Vol: 32, Pages: 265A-265A, ISSN: 0270-9139
Hoare JM, Henkler F, Goldin RD, et al., 2000, The in vivo expression and sub-cellular localisation of the hepatitis B X protein, JOURNAL OF HEPATOLOGY, Vol: 32, Pages: 173-173, ISSN: 0168-8278
Errington W, Wardell AD, McDonald S, et al., 1999, Subcellular localisation of NS3 in HCV-infected hepatocytes, JOURNAL OF MEDICAL VIROLOGY, Vol: 59, Pages: 456-462, ISSN: 0146-6615
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- Citations: 22
Grace K, Gartland M, Karayiannis P, et al., 1999, The 5 ' untranslated region of GB virus B shows functional similarity to the internal ribosome entry site of hepatitis C virus, JOURNAL OF GENERAL VIROLOGY, Vol: 80, Pages: 2337-2341, ISSN: 0022-1317
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- Citations: 31
Wardell AD, Errington W, Ciaramella G, et al., 1999, Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein, JOURNAL OF GENERAL VIROLOGY, Vol: 80, Pages: 701-709, ISSN: 0022-1317
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- Citations: 84
O'Donnell DR, McGarvey MJ, Tully JM, et al., 1998, Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection, JOURNAL OF PEDIATRICS, Vol: 133, Pages: 272-274, ISSN: 0022-3476
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- Citations: 44
Aiba N, McGarvey MJ, Waters J, et al., 1997, The precore sequence of hepatitis B virus is required for nuclear localization of the core protein, HEPATOLOGY, Vol: 26, Pages: 1311-1317, ISSN: 0270-9139
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- Citations: 11
Karayiannis P, Hadziyannis SJ, Kim J, et al., 1997, Hepatitis G virus infection: Clinical characteristics and response to interferon, JOURNAL OF VIRAL HEPATITIS, Vol: 4, Pages: 37-44, ISSN: 1352-0504
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- Citations: 40
McGarvey MJ, Goldin RD, Karayiannis P, et al., 1996, The expression of hepatitis B virus polymerase in hepatocytes during chronic HBV infection, JOURNAL OF VIRAL HEPATITIS, Vol: 3, Pages: 67-73, ISSN: 1352-0504
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- Citations: 5
Karayiannis P, McGarvey MJ, 1995, The GB hepatitis viruses, JOURNAL OF VIRAL HEPATITIS, Vol: 2, Pages: 221-226, ISSN: 1352-0504
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- Citations: 22
THURSZ MR, FOSTER GR, MCGARVEY MJ, et al., 1994, EXPRESSION OF HBV POLYMERASE IN HBV RELATED HEPATOCELLULAR-CARCINOMA, GUT, Vol: 35, Pages: A720-A720, ISSN: 0017-5749
THURSZ MR, FOSTER GR, MCGARVEY MJ, et al., 1994, EXPRESSION OF HBV POLYMERASE IN HBV RELATED HEPATOCELLULAR-CARCINOMA, Publisher: W B SAUNDERS CO, Pages: A998-A998, ISSN: 0016-5085
FOSTER GR, GOLDIN RD, HAY A, et al., 1993, EXPRESSION OF THE TERMINAL PROTEIN OF HEPATITIS-B VIRUS IS ASSOCIATED WITH FAILURE TO RESPOND TO INTERFERON THERAPY, HEPATOLOGY, Vol: 17, Pages: 757-762, ISSN: 0270-9139
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- Citations: 22
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