Imperial College London

DrMichaelMcGarvey

Faculty of MedicineDepartment of Infectious Disease

Emeritus Reader in Molecular Virology
 
 
 
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Contact

 

+44 (0)20 7594 9035m.mcgarvey

 
 
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Location

 

331Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
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40 results found

Butnariu A-B, Look A, Grillo M, Tabish TA, McGarvey MJ, Pranjol MZet al., 2021, SARS-CoV-2-host cell surface interactions and potential antiviral therapies, Interface Focus, Vol: 12, Pages: 1-9, ISSN: 2042-8901

In this review, we reveal the latest developments at the interface between SARS-CoV-2 and the host cell surface. In particular, we evaluate the current and potential mechanisms of binding, fusion and the conformational changes of the spike (S) protein to host cell surface receptors, especially the human angiotensin-converting enzyme 2 (ACE2) receptor. For instance, upon the initial attachment, the receptor binding domain of the S protein forms primarily hydrogen bonds with the protease domain of ACE2 resulting in conformational changes within the secondary structure. These surface interactions are of paramount importance and have been therapeutically exploited for antiviral design, such as monoclonal antibodies. Additionally, we provide an insight into novel therapies that target viral non-structural proteins, such as viral RNA polymerase. An example of which is remdesivir which has now been approved for use in COVID-19 patients by the US Food and Drug Administration. Establishing further understanding of the molecular details at the cell surface will undoubtably aid the development of more efficacious and selectively targeted therapies to reduce the burden of COVID-19.

Journal article

McGarvey MJ, Houghton M, 2014, Structure and molecular virology, VIRAL HEPATITIS, 4TH EDITION, Editors: Thomas, Lok, Locarnini, Zuckerman, Publisher: BLACKWELL SCIENCE PUBL, Pages: 221-245

Book chapter

Janahi EM, McGarvey MJ, 2013, The inhibition of hepatitis B virus by APOBEC cytidine deaminases, JOURNAL OF VIRAL HEPATITIS, Vol: 20, Pages: 821-828, ISSN: 1352-0504

Journal article

Blackham SL, McGarvey MJ, 2013, A host cell RNA-binding protein, Staufen1, has a role in hepatitis C virus replication before virus assembly, JOURNAL OF GENERAL VIROLOGY, Vol: 94, Pages: 2429-2436, ISSN: 0022-1317

Journal article

Blackham S, Baillie A, Al-Hababi F, Remlinger K, You S, Hamatake R, McGarvey MJet al., 2010, Gene Expression Profiling Indicates the Roles of Host Oxidative Stress, Apoptosis, Lipid Metabolism, and Intracellular Transport Genes in the Replication of Hepatitis C Virus, JOURNAL OF VIROLOGY, Vol: 84, Pages: 5404-5414, ISSN: 0022-538X

Journal article

McGarvey MJ, Iqbal M, Nastos T, Karayiannis Pet al., 2008, Restricted quasispecies variation following infection with the GB virus B, VIRUS RESEARCH, Vol: 135, Pages: 181-186, ISSN: 0168-1702

Journal article

Mohammed E, Navaratnam N, Hoare JM, McGarvey MJet al., 2006, The effects of APOBEC3G on HBV replication, 12th International Symposium on Viral Hepatitis and Liver Disease, Publisher: ELSEVIER SCIENCE BV, Pages: S67-S67, ISSN: 1386-6532

Conference paper

Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EMA, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BLet al., 2006, Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus <i>X</i> protein, VIROLOGY, Vol: 347, Pages: 466-475, ISSN: 0042-6822

Journal article

Moore MD, McGarvey MJ, Russell RA, Cullen BR, McClure MOet al., 2005, Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors, JOURNAL OF GENE MEDICINE, Vol: 7, Pages: 918-925, ISSN: 1099-498X

Journal article

Hoare J, Waddington S, Thomas HC, Coutelle C, McGarvey MJet al., 2005, Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice, JOURNAL OF GENE MEDICINE, Vol: 7, Pages: 325-333, ISSN: 1099-498X

Journal article

McGarvey MJ, Houghton M, 2005, Hepatitis C Virus: Structure and Molecular Virology, Viral Hepatitis, Editors: Thomas, Lemon, Zuckerman, Malden, Massachusetts, Publisher: Blackwell Publishing Inc., Pages: 381-406, ISBN: 978-1-4051-3005-9

Book chapter

McGarvey MJ, Houghton M, 2005, Structure and molecular virology, VIRAL HEPATITIS, 3RD EDITION, Editors: Thomas, Lemon, Zuckerman, Publisher: BLACKWELL SCIENCE PUBL, Pages: 381-406, ISBN: 978-1-4051-3005-9

Book chapter

Caronia S, McGarvey MJ, Goldin RD, Foster GRet al., 2004, Negative correlation between intrahepatic expression of hepatitis C antigens and apoptosis despite high-level expression of Fas and HLA antigens, JOURNAL OF VIRAL HEPATITIS, Vol: 11, Pages: 511-518, ISSN: 1352-0504

Journal article

Gallivan JP, McGarvey MJ, 2003, The importance of the Q motif in the ATPase activity of a viral helicase, FEBS LETTERS, Vol: 554, Pages: 485-488, ISSN: 0014-5793

Journal article

Moore MD, McGarvey MJ, McClure MO, 2003, RNA interference of HBV gene expression, Molecular Therapy, Vol: 7, Pages: S30-S30

Journal article

Hoare J, Henkler F, Dowling JJ, Errington W, Goldin RD, Fish D, McGarvey MJet al., 2001, Subcellular localisation of the X protein in HBV infected hepatocytes, JOURNAL OF MEDICAL VIROLOGY, Vol: 64, Pages: 419-426, ISSN: 0146-6615

Journal article

Hoare J, Botto M, Thomas HC, McGarvey MJet al., 2001, The inactivation of baculovirus vectors by the innate immune system, JOURNAL OF HEPATOLOGY, Vol: 34, Pages: 222-222, ISSN: 0168-8278

Journal article

Henkler F, Hoare J, Waseem N, Goldin RD, McGarvey MJ, Koshy R, King IAet al., 2001, Intracellular localization of the hepatitis B virus HBx protein, JOURNAL OF GENERAL VIROLOGY, Vol: 82, Pages: 871-882, ISSN: 0022-1317

Journal article

Caronia S, Gulati V, McGarvey MJ, Goldin RD, Foster GRet al., 2000, Hepatitis C virus infected hepatocytes and apoptosis., HEPATOLOGY, Vol: 32, Pages: 265A-265A, ISSN: 0270-9139

Journal article

Hoare JM, Henkler F, Robert GD, Koshy R, McGarvey MJet al., 2000, The subcellular localisation of the X protein in HBV infected hepatocytes., HEPATOLOGY, Vol: 32, Pages: 448A-448A, ISSN: 0270-9139

Journal article

Hoare JM, Henkler F, Goldin RD, McGarvey MJet al., 2000, The <i>in vivo</i> expression and sub-cellular localisation of the hepatitis B X protein, JOURNAL OF HEPATOLOGY, Vol: 32, Pages: 173-173, ISSN: 0168-8278

Journal article

Errington W, Wardell AD, McDonald S, Goldin RD, McGarvey MJet al., 1999, Subcellular localisation of NS3 in HCV-infected hepatocytes, JOURNAL OF MEDICAL VIROLOGY, Vol: 59, Pages: 456-462, ISSN: 0146-6615

Journal article

Grace K, Gartland M, Karayiannis P, McGarvey MJ, Clarke Bet al., 1999, The 5′ untranslated region of GB virus B shows functional similarity to the internal ribosome entry site of hepatitis C virus, JOURNAL OF GENERAL VIROLOGY, Vol: 80, Pages: 2337-2341, ISSN: 0022-1317

Journal article

Wardell AD, Errington W, Ciaramella G, Merson J, McGarvey MJet al., 1999, Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein, JOURNAL OF GENERAL VIROLOGY, Vol: 80, Pages: 701-709, ISSN: 0022-1317

Journal article

O'Donnell DR, McGarvey MJ, Tully JM, Balfour-Lynn IM, Openshaw PJMet al., 1998, Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection, JOURNAL OF PEDIATRICS, Vol: 133, Pages: 272-274, ISSN: 0022-3476

Journal article

Aiba N, McGarvey MJ, Waters J, Hadziyannis SJ, Thomas HC, Karayiannis Pet al., 1997, The precore sequence of hepatitis B virus is required for nuclear localization of the core protein, HEPATOLOGY, Vol: 26, Pages: 1311-1317, ISSN: 0270-9139

Journal article

Karayiannis P, Hadziyannis SJ, Kim J, Pickering JM, Piatak M, Hess G, Yun A, McGarvey MJ, Wages J, Thomas HCet al., 1997, Hepatitis G virus infection: Clinical characteristics and response to interferon, JOURNAL OF VIRAL HEPATITIS, Vol: 4, Pages: 37-44, ISSN: 1352-0504

Journal article

McGarvey MJ, Goldin RD, Karayiannis P, Thomas HCet al., 1996, The expression of hepatitis B virus polymerase in hepatocytes during chronic HBV infection, JOURNAL OF VIRAL HEPATITIS, Vol: 3, Pages: 67-73, ISSN: 1352-0504

Journal article

Karayiannis P, McGarvey MJ, 1995, The GB hepatitis viruses, JOURNAL OF VIRAL HEPATITIS, Vol: 2, Pages: 221-226, ISSN: 1352-0504

Journal article

THURSZ MR, FOSTER GR, MCGARVEY MJ, THOMAS HC, GOLDIN RDet al., 1994, EXPRESSION OF HBV POLYMERASE IN HBV RELATED HEPATOCELLULAR-CARCINOMA, GUT, Vol: 35, Pages: A720-A720, ISSN: 0017-5749

Journal article

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