Imperial College London
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PROFESSOR MIRIAM F. MOFFATT

Faculty of Medicine, National Heart & Lung Institute

Consul for the Faculty of Medicine, Professor
 
 
 
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Contact

 

+44 (0)20 7594 2942m.moffatt

 
 
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Location

 

400Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Habibi:2020:10.1126/science.aba9301,
author = {Habibi, MS and Thwaites, RS and Chang, M and Jozwik, A and Paras, A and Kirsebom, F and Varese, A and Owen, A and Cuthbertson, L and James, P and Tunstall, T and Nickle, D and Hansel, TT and Moffatt, MF and Johansson, C and Chiu, C and Openshaw, PJM},
doi = {10.1126/science.aba9301},
journal = {Science},
title = {Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.},
url = {http://dx.doi.org/10.1126/science.aba9301},
volume = {370},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The variable outcome of viral exposure is only partially explained by known factors. We administered respiratory syncytial virus (RSV) to 58 volunteers, of whom 57% became infected. Mucosal neutrophil activation before exposure was highly predictive of symptomatic RSV disease. This was associated with a rapid, presymptomatic decline in mucosal interleukin-17A (IL-17A) and other mediators. Conversely, those who resisted infection showed presymptomatic activation of IL-17- and tumor necrosis factor-related pathways. Vulnerability to infection was not associated with baseline microbiome but was reproduced in mice by preinfection chemokine-driven airway recruitment of neutrophils, which caused enhanced disease mediated by pulmonary CD8+ T cell infiltration. Thus, mucosal neutrophilic inflammation at the time of RSV exposure enhances susceptibility, revealing dynamic, time-dependent local immune responses before symptom onset and explaining the as-yet unpredictable outcomes of pathogen exposure.
AU  - Habibi,MS
AU  - Thwaites,RS
AU  - Chang,M
AU  - Jozwik,A
AU  - Paras,A
AU  - Kirsebom,F
AU  - Varese,A
AU  - Owen,A
AU  - Cuthbertson,L
AU  - James,P
AU  - Tunstall,T
AU  - Nickle,D
AU  - Hansel,TT
AU  - Moffatt,MF
AU  - Johansson,C
AU  - Chiu,C
AU  - Openshaw,PJM
DO  - 10.1126/science.aba9301
PY  - 2020///
TI  - Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.
T2  - Science
UR  - http://dx.doi.org/10.1126/science.aba9301
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33033192
UR  - http://hdl.handle.net/10044/1/82442
VL  - 370
ER  -
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