Summary
Michela Noseda is Lecturer of Cardiac Molecular Pathology at the National Heart and Lung Institute.
Dr Noseda is PI of the international consortium funded by BHF/DZHK aiming to define the molecular and cellular drivers of heart failure, a co-PI in the consortium funded by CZI aiming to build a human heart cell atlas and is a co-lead of the Heart Biological Network within the space of the Human Cell Atlas.
As an expert in multiomic approaches for the assessment of cardiovascular disease, Dr Noseda was a leading member of the interdisciplinary and international teams who assembled the first version of the Human Heart Cell Atlas including 6 anatomical regions and a v2 including 8 sites. Dr Noseda was also co-lead of the paradigm changing study demonstrating that the cellular and molecular architectures that induce heart failure are both shared and distinct across genotypes in dilated cardiomyopathies.
Dr Noseda is a strong supporter of team science and open to new collaborations and consultancy.
How did I get here?
Dr Noseda received her medical training at the Universita' Cattolica del Sacro Cuore in Rome Italy. Here, she also established the fundamentals of her molecular and cellular biology training. She has subsequently moved with Dr Anna Lasorella and Dr Antonio iavarone at Albert Einstein College of Medicine (NY, USA) thanks to a fellowship (Borsa di studio Beatrice Angelini) and at the University of British Columbia where she was awarded three fellowships from the Canadian Institute of Health Research, Michael Smith Foundation for Health Research and Fondazione Italiana Ricerca sul Cancro) under the supervision of Dr Aly Karsan. In this phase of research she studied paediatric cancer and angiogenesis. During studies on vascular development Dr Noseda discovered an important role for the Notch family of proteins in cardiac development. This critical phase of her training prompted the need to further her experience in cardiac development and cardiac disease in one of the top cardiac science laboratories in the world, joining Professor Michael Schneider’s group at Baylor College of Medicine (Houston Texas, US) where she initiated her work on adult cardiac progenitors which was continued in the UK at Imperial College London. Dr Noseda has subsequently established her research group at Imperial College.
Publications
Journals
Jones RE, Gruszczyk AV, Schmidt C, et al., 2023, Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease, Nature Cardiovascular Research, Vol:2, ISSN:2731-0590, Pages:733-745
Kanemaru K, Cranley J, Muraro D, et al., 2023, Spatially resolved multiomics of human cardiac niches, Nature, Vol:619, ISSN:0028-0836, Pages:801-810
Tadros R, Zheng SL, Grace C, et al., 2023, Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy., Medrxiv
Miranda AMA, Janbandhu V, Maatz H, et al., 2022, Single-cell transcriptomics for the assessment of cardiac disease, Nature Reviews Cardiology, ISSN:1759-5002
Conference
Reichart D, Lindberg EL, Maatz H, et al., 2022, Pathogenic variants damage cell compositions and single cell transcription in cardiomyopathies, OXFORD UNIV PRESS, Pages:2992-2992, ISSN:0195-668X