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@article{Chang:2012:10.1073/pnas.1118512109,
author = {Chang, L and Noseda, M and Higginson, M and Ly, M and Patenaude, A and Fuller, M and Kyle, AH and Minchinton, AI and Puri, MC and Dumont, DJ and Karsan, A},
doi = {10.1073/pnas.1118512109},
journal = {Proc Natl Acad Sci U S A},
pages = {6993--6998},
title = {Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling.},
url = {http://dx.doi.org/10.1073/pnas.1118512109},
volume = {109},
year = {2012}
}

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TY  - JOUR
AB  - Vascular smooth muscle cells (VSMC) have been suggested to arise from various developmental sources during embryogenesis, depending on the vascular bed. However, evidence also points to a common subpopulation of vascular progenitor cells predisposed to VSMC fate in the embryo. In the present study, we use binary transgenic reporter mice to identify a Tie1(+)CD31(dim)vascular endothelial (VE)-cadherin(-)CD45(-) precursor that gives rise to VSMC in vivo in all vascular beds examined. This precursor does not represent a mature endothelial cell, because a VE-cadherin promoter-driven reporter shows no expression in VSMC during murine development. Blockade of Notch signaling in the Tie1(+) precursor cell, but not the VE-cadherin(+) endothelial cell, decreases VSMC investment of developing arteries, leading to localized hemorrhage in the embryo at the time of vascular maturation. However, Notch signaling is not required in the Tie1(+) precursor after establishment of a stable artery. Thus, Notch activity is required in the differentiation of a Tie1(+) local precursor to VSMC in a spatiotemporal fashion across all vascular beds.
AU  - Chang,L
AU  - Noseda,M
AU  - Higginson,M
AU  - Ly,M
AU  - Patenaude,A
AU  - Fuller,M
AU  - Kyle,AH
AU  - Minchinton,AI
AU  - Puri,MC
AU  - Dumont,DJ
AU  - Karsan,A
DO  - 10.1073/pnas.1118512109
EP  - 6998
PY  - 2012///
SP  - 6993
TI  - Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling.
T2  - Proc Natl Acad Sci U S A
UR  - http://dx.doi.org/10.1073/pnas.1118512109
UR  - https://www.ncbi.nlm.nih.gov/pubmed/22509029
VL  - 109
ER  -

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