Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Reader in Immunology







605Sir Alexander Fleming BuildingSouth Kensington Campus





Dr Masahiro Ono is an immunologist and expert in T-cell regulation. His research focuses on mechanisms of T cell activation and regulation in autoimmunity, infections, and cancer. He is the pioneer of the Timer-of-Cell-Kinetics-and-Activity (Tocky, とき), which analyses temporal dynamics of cellular differentiation in vivo.

Dr Ono was originally trained as a dermatologist, and later specialised in immunology. He obtained his PhD in 2006 by a study on regulatory T cells (Treg), and later identified the interaction of the Treg-specific transcription factor Foxp3 and the transcription factor Runx1. In 2009, he obtained a HFSP Fellowship, and joined University College London (UCL), when he established a new genomic analysis tool using a multidimensional method, Canonical Correspondence Analysis (CCA). In 2012, he was awarded a BBSRC David Phillips Fellowship, and established his lab in UCL. In 2015, he moved in the Department of Life Sciences, Imperial, and was appointed as Senior Lecturer in 2018.

The lab website



Kalfaoglu B, Almeida-Santos J, Tye C, et al., T-cell hyperactivation and paralysis in severe COVID-19 infection revealed bysingle-cell analysis, Frontiers in Immunology, ISSN:1664-3224

Piras G, Rattazzi L, Paschalidis N, et al., 2020, Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells, Brain Behavior and Immunity, Vol:87, ISSN:0889-1591, Pages:689-702

Ono M, 2020, Control of regulatory T-cell differentiation and function by T-cell receptor signalling and Foxp3 transcription factor complexes, Immunology, Vol:160, ISSN:0019-2805, Pages:24-37

Jennings E, Elliot TAE, Thawait N, et al., 2019, Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

Papaioannou E, Yanez DC, Ross S, et al., 2019, Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation, Journal of Clinical Investigation, Vol:129, ISSN:0021-9738, Pages:3153-3170

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