Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Reader in Immunology







605Sir Alexander Fleming BuildingSouth Kensington Campus





Dr Masahiro Ono is an immunologist and expert in T-cell regulation. His research focuses on mechanisms of T cell activation and regulation in autoimmunity, infections, and cancer. He is the pioneer of the Timer-of-Cell-Kinetics-and-Activity (Tocky, とき), which analyses temporal dynamics of cellular differentiation in vivo.

Dr Ono was originally trained as a dermatologist, and later specialised in immunology. He obtained his PhD in 2006 by a study on regulatory T cells (Treg), and later identified the interaction of the Treg-specific transcription factor Foxp3 and the transcription factor Runx1. In 2009, he obtained a HFSP Fellowship, and joined University College London (UCL), when he established a new genomic analysis tool using a multidimensional method, Canonical Correspondence Analysis (CCA). In 2012, he was awarded a BBSRC David Phillips Fellowship, and established his lab in UCL. In 2015, he moved in the Department of Life Sciences, Imperial, and was appointed as Senior Lecturer in 2018.

The lab website

CRUK Convergence Science Centre



Jennings EK, Lecky DAJ, Ono M, et al., 2021, Application of dual Nr4a1-GFP Nr4a3-Tocky reporter mice to study T cell receptor signaling by flow cytometry., Star Protoc, Vol:2

Jennings E, Elliot TAE, Thawait N, et al., 2020, Nr4a1 and Nr4a3 reporter mice are differentially sensitive to T cell receptor signal strength and duration., Cell Research, Vol:33, ISSN:1001-0602, Pages:1-15

Kalfaoglu B, Almeida-Santos J, Tye CA, et al., 2020, T-cell dysregulation in COVID-19, Biochemical and Biophysical Research Communications, ISSN:0006-291X

Kalfaoglu B, Almeida-Santos J, Tye C, et al., 2020, T-cell hyperactivation and paralysis in severe COVID-19 infection revealed bysingle-cell analysis, Frontiers in Immunology, Vol:11, ISSN:1664-3224

Piras G, Rattazzi L, Paschalidis N, et al., 2020, Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells, Brain Behavior and Immunity, Vol:87, ISSN:0889-1591, Pages:689-702

More Publications