Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Reader in Immunology







605Sir Alexander Fleming BuildingSouth Kensington Campus





Dr Masahiro Ono is an immunologist and expert in T-cell regulation. His research focuses on mechanisms of T cell activation and regulation in autoimmunity, infections, and cancer. He is the pioneer of the Timer-of-Cell-Kinetics-and-Activity (Tocky, とき), which analyses temporal changes of T-cell activities in vivo using Fluorescent Timer protein.

Dr Ono did his undergraduate in Faculty of Medicine, Kyoto University (1993-1999, MD) and later was trained in dermatology. He did his PhD in 2002 - 2006 in the study of regulatory T cells (Tregs) and the transcription factors Foxp3 and Runx1, starting his immunology career. In 2009, he obtained a HFSP Fellowship, and joined University College London (UCL), when he extended his research to immunological genomics. In 2012, he was awarded a BBSRC David Phillips Fellowship, and established his lab in UCL. He joined Imperial in 2015 and was appointed as a Senior Lecturer in 2018. He was promoted to a Reader in Immunology in 2020.

The lab website

CRUK Convergence Science Centre



Jennings EK, Lecky DAJ, Ono M, et al., 2021, Application of dual Nr4a1-GFP Nr4a3-Tocky reporter mice to study T cell receptor signaling by flow cytometry., Star Protoc, Vol:2

Jennings E, Elliot TAE, Thawait N, et al., 2020, Nr4a1 and Nr4a3 reporter mice are differentially sensitive to T cell receptor signal strength and duration., Cell Research, Vol:33, ISSN:1001-0602, Pages:1-15

Kalfaoglu B, Almeida-Santos J, Tye CA, et al., 2020, T-cell dysregulation in COVID-19, Biochemical and Biophysical Research Communications, ISSN:0006-291X

Kalfaoglu B, Almeida-Santos J, Tye C, et al., 2020, T-cell hyperactivation and paralysis in severe COVID-19 infection revealed bysingle-cell analysis, Frontiers in Immunology, Vol:11, ISSN:1664-3224

Piras G, Rattazzi L, Paschalidis N, et al., 2020, Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells, Brain Behavior and Immunity, Vol:87, ISSN:0889-1591, Pages:689-702

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