Summary
Dr Masahiro Ono is an immunologist and expert in T-cell regulation. His research focuses on mechanisms of T cell activation and regulation in autoimmunity, infections, and cancer. He is the pioneer of the Timer-of-Cell-Kinetics-and-Activity (Tocky, とき), which analyses temporal changes of T-cell activities in vivo using Fluorescent Timer protein.
Dr Ono did his undergraduate in Faculty of Medicine, Kyoto University (1993-1999, MD) and later was trained in dermatology. He did his PhD in 2002 - 2006 in the study of regulatory T cells (Tregs) and the transcription factors Foxp3 and Runx1, starting his immunology career. In 2009, he obtained a HFSP Fellowship, and joined University College London (UCL), when he extended his research to immunological genomics. In 2012, he was awarded a BBSRC David Phillips Fellowship, and established his lab in UCL. He joined Imperial in 2015 and was appointed as a Senior Lecturer in 2018. He was promoted to a Reader in Immunology in 2020.
Publications
Journals
Reda O, Monde K, Sugata K, et al., 2024, HIV-Tocky system to visualize proviral expression dynamics., Commun Biol, Vol:7
Ono M, 2024, Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system, Biophysics and Physicobiology
Copland A, Mackie GM, Scarfe L, et al., 2023, <i>Salmonella</i>cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity
Tan BJY, Sugata K, Ono M, et al., 2022, HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune system, Frontiers in Immunology, Vol:13, ISSN:1664-3224
Whyte CEE, Singh K, Burton OTT, et al., 2022, Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits (vol 219, e2021239107142022cpg , 2022), Journal of Experimental Medicine, Vol:219, ISSN:0022-1007