Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Reader in Immunology







605Sir Alexander Fleming BuildingSouth Kensington Campus





Dr Masahiro Ono is an immunologist and expert in T-cell regulation. His research focuses on mechanisms of T cell activation and regulation in autoimmunity, infections, and cancer. He is the pioneer of the Timer-of-Cell-Kinetics-and-Activity (Tocky, とき), which analyses temporal changes of T-cell activities in vivo using Fluorescent Timer protein.

Dr Ono did his undergraduate in Faculty of Medicine, Kyoto University (1993-1999, MD) and later was trained in dermatology. He did his PhD in 2002 - 2006 in the study of regulatory T cells (Tregs) and the transcription factors Foxp3 and Runx1, starting his immunology career. In 2009, he obtained a HFSP Fellowship, and joined University College London (UCL), when he extended his research to immunological genomics. In 2012, he was awarded a BBSRC David Phillips Fellowship, and established his lab in UCL. He joined Imperial in 2015 and was appointed as a Senior Lecturer in 2018. He was promoted to a Reader in Immunology in 2020.

The lab website

CRUK Convergence Science Centre



Hamilton A, Rizzo R, Brod S, et al., 2022, The immunomodulatory effects of social isolation in mice are linked to temperature control, Brain Behavior and Immunity, Vol:102, ISSN:0889-1591, Pages:179-194

Tan BJY, Sugata K, Reda O, et al., 2021, HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma, Journal of Clinical Investigation, Vol:131, ISSN:0021-9738

Bortoluzzi S, Dashtsoodol N, Engleitner T, et al., 2021, Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling, Immunity, Vol:54, ISSN:1074-7613, Pages:2497-+

Abe H, Tanada Y, Omiya S, et al., 2021, NF-kappa B activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C(hi) monocytes in pressure-overloaded hearts, Science Signaling, Vol:14, ISSN:1945-0877

Ono M, 2021, Restoring control over autoimmunity by inducing Foxp3, Nature Immunology, Vol:22, ISSN:1529-2908, Pages:1080-1082

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