Imperial College London
Portrait Picture

DrMasahiroOno

Faculty of Natural Sciences, Department of Life Sciences

Reader in Immunology
 
 
 
//

Contact

 

m.ono

 
 
//

Location

 

605Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Kalfaoglu:2020:10.1016/j.bbrc.2020.10.079,
author = {Kalfaoglu, B and Almeida-Santos, J and Tye, CA and Satou, Y and Ono, M},
doi = {10.1016/j.bbrc.2020.10.079},
journal = {Biochemical and Biophysical Research Communications},
title = {T-cell dysregulation in COVID-19},
url = {http://dx.doi.org/10.1016/j.bbrc.2020.10.079},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - T-cells play key roles in immunity to COVID-19 as well as the development of severe disease. T-cell immunity to COVID-19 is mediated through differentiated CD4+ T-cells and cytotoxic CD8+ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized. Notably, T-cells are dysregulated in severe COVID-19 patients, although their molecular features are still yet to be fully revealed. Importantly, it is not clear which T-cell activities are beneficial and protective and which ones can contribute to the development of severe COVID-19. In this article, we examine the latest evidence and discuss the key features of T-cell responses in COVID-19, showing how T-cells are dysregulated in severe COVID-19 patients. Particularly, we highlight the impairment of FOXP3 induction in CD4+ T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients. Furthermore, we characterise the feature of hyperactivated T-cells, showing their potential contribution to T-cell dysregulation and immune-mediated tissue destruction (immunopathology) in COVID-19.
AU  - Kalfaoglu,B
AU  - Almeida-Santos,J
AU  - Tye,CA
AU  - Satou,Y
AU  - Ono,M
DO  - 10.1016/j.bbrc.2020.10.079
PY  - 2020///
SN  - 0006-291X
TI  - T-cell dysregulation in COVID-19
T2  - Biochemical and Biophysical Research Communications
UR  - http://dx.doi.org/10.1016/j.bbrc.2020.10.079
UR  - https://www.sciencedirect.com/science/article/pii/S0006291X20320088?via%3Dihub
UR  - http://hdl.handle.net/10044/1/83897
ER  -
Download