Imperial College London

ProfessorMaryRyan

Faculty of EngineeringDepartment of Materials

Vice-Dean (Research), Faculty of Engineering
 
 
 
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Contact

 

+44 (0)20 7594 6755m.p.ryan

 
 
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Location

 

B338Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mukherjee:2015:10.3390/nano5031223,
author = {Mukherjee, D and Porter, A and Ryan, M and Schwander, S and Chung, KF and Tetley, T and Zhang, J and Georgopoulos, P},
doi = {10.3390/nano5031223},
journal = {Nanomaterials},
pages = {1223--1249},
title = {Modeling in vivo interactions of engineered nanoparticles in the pulmonary alveolar lining fluid},
url = {http://dx.doi.org/10.3390/nano5031223},
volume = {5},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Increasing use of engineered nanomaterials (ENMs) in consumer products may result in widespread human inhalation exposures. Due to their high surface area per unit mass, inhaled ENMs interact with multiple components of the pulmonary system, and these interactions affect their ultimate fate in the body. Modeling of ENM transport and clearance in vivo has traditionally treated tissues as well-mixed compartments, without consideration of nanoscale interaction and transformation mechanisms. ENM agglomeration, dissolution and transport, along with adsorption of biomolecules, such as surfactant lipids and proteins, cause irreversible changes to ENM morphology and surface properties. The model presented in this article quantifies ENM transformation and transport in the alveolar air to liquid interface and estimates eventual alveolar cell dosimetry. This formulation brings together established concepts from colloidal and surface science, physics, and biochemistry to provide a stochastic framework capable of capturing essential in vivo processes in the pulmonary alveolar lining layer. The model has been implemented for in vitro solutions with parameters estimated from relevant published in vitro measurements and has been extended here to in vivo systems simulating human inhalation exposures. Applications are presented for four different ENMs, and relevant kinetic rates are estimated, demonstrating an approach for improving human in vivo pulmonary dosimetry.
AU - Mukherjee,D
AU - Porter,A
AU - Ryan,M
AU - Schwander,S
AU - Chung,KF
AU - Tetley,T
AU - Zhang,J
AU - Georgopoulos,P
DO - 10.3390/nano5031223
EP - 1249
PY - 2015///
SN - 2079-4991
SP - 1223
TI - Modeling in vivo interactions of engineered nanoparticles in the pulmonary alveolar lining fluid
T2 - Nanomaterials
UR - http://dx.doi.org/10.3390/nano5031223
UR - http://hdl.handle.net/10044/1/33354
VL - 5
ER -