Publications
179 results found
Chan AL, Morris HR, Panico M, et al., 1991, A novel sialylated N-acetylgalactosamine-containing oligosaccharide is the major complex-type structure present in Bowes melanoma tissue plasminogen activator., Glycobiology, Vol: 1, Pages: 173-185, ISSN: 0959-6658
We have employed fast atom bombardment mass spectrometry (FAB-MS) to screen the N-linked oligosaccharides of Bowes melanoma tissue plasminogen activator (mt-PA), and recombinant t-PAs produced by Chinese hamster ovary cells (rt-PA) and by a gene-enriched melanoma cell line (rmt-PA). These studies have confirmed the published structures for rt-PA, but are not in agreement with some of the structures reported for mt-PA. In the latter glycoprotein we have identified a novel structure as the major oligosaccharide attached to Asn-184 and Asn-448. This is a biantennary oligosaccharide consisting of a fucosylated trimannosyl core to which are attached two GalNAc(1----4)GlcNAc antennae, one of which carries a sialic acid linked at the 6-position of the GalNAc. Minor constituents are sialylated on both or neither antennae. The sialylated GalNAc moiety is unique in N-linked glycoproteins. The majority of complex structures in rmt-PA contain N-acetyllactosamine moieties at both the Asn-184 and Asn-448 sites with the novel oligosaccharide occurring as a minor component at the Asn-184 site. This study demonstrates the power of mass spectrometric strategies based on high-field two-sector FAB-MS for structure elucidations of natural and recombinant glycoproteins.
CASO R, LANE DA, THOMPSON EA, et al., 1991, ANTITHROMBIN VICENZA, ALA-384 TO PRO (GCA TO CCA) MUTATION, TRANSFORMING THE INHIBITOR INTO A SUBSTRATE, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 77, Pages: 87-92, ISSN: 0007-1048
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- Citations: 45
MORRIS HR, PUCCI P, PANICO M, et al., 1990, PROTEIN FOLDING REFOLDING ANALYSIS BY MASS-SPECTROMETRY - SCRAMBLING OF DISULFIDE BRIDGES IN INSULIN, BIOCHEMICAL JOURNAL, Vol: 268, Pages: 803-806, ISSN: 0264-6021
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- Citations: 14
WILLIAMSON RA, MARSTON FAO, ANGAL S, et al., 1990, DISULFIDE BOND ASSIGNMENT IN HUMAN TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP), BIOCHEMICAL JOURNAL, Vol: 268, Pages: 267-274, ISSN: 0264-6021
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- Citations: 171
CASO R, LANE DA, THOMPSON E, et al., 1990, ANTITHROMBIN-PADUA .1. IMPAIRED HEPARIN BINDING CAUSED BY AN ARG47 TO HIS (CGT TO CAT) SUBSTITUTION, THROMBOSIS RESEARCH, Vol: 58, Pages: 185-190, ISSN: 0049-3848
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- Citations: 19
WIMALAWANSA SJ, MORRIS HR, ETIENNE A, et al., 1990, ISOLATION, PURIFICATION AND CHARACTERIZATION OF BETA-HCGRP FROM HUMAN SPINAL-CORD, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 167, Pages: 993-1000, ISSN: 0006-291X
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- Citations: 31
CASO R, LANE DA, THOMPSON E, et al., 1989, ANTITHROMBIN PADUA-I, DECREASED HEPARIN BINDING CAUSED BY A 47ARG TO HIS SUBSTITUTION ARISING FROM A CPG MUTATION, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 73, Pages: 440-440, ISSN: 0007-1048
LANE DA, ERDJUMENT H, THOMPSON E, et al., 1989, A NOVEL AMINO-ACID SUBSTITUTION IN THE REACTIVE SITE OF A CONGENITAL VARIANT ANTITHROMBIN - ANTITHROMBIN PESCARA, ARG393 TO PRO, CAUSED BY A CGT TO CCT MUTATION, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 264, Pages: 10200-10204, ISSN: 0021-9258
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- Citations: 34
ERDJUMENT H, LANE DA, PANICO M, et al., 1989, ANTITHROMBIN CHICAGO, AMINO-ACID SUBSTITUTION OF ARGININE-393 TO HISTIDINE, THROMBOSIS RESEARCH, Vol: 54, Pages: 613-619, ISSN: 0049-3848
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- Citations: 21
Morris HR, Chatterjee A, Panico M, et al., 1989, Linked Scans of Peptides and Protein Digests: Amino Acid Sequence Determination of Components of Complex Mixtures, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 3, Pages: 110-116, ISSN: 0951-4198
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- Citations: 7
LANE DA, ERDJUMENT H, FLYNN A, et al., 1989, ANTITHROMBIN SHEFFIELD - AMINO-ACID SUBSTITUTION AT THE REACTIVE SITE (ARG393 TO HIS) CAUSING THROMBOSIS, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 71, Pages: 91-96, ISSN: 0007-1048
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- Citations: 29
ERDJUMENT H, LANE DA, IRELAND H, et al., 1988, ANTITHROMBIN MILANO, SINGLE AMINO-ACID SUBSTITUTION AT THE REACTIVE SITE, ARG393 TO CYS, THROMBOSIS AND HAEMOSTASIS, Vol: 60, Pages: 471-475, ISSN: 0340-6245
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- Citations: 25
KALLENDER H, PETTY ITD, STEIN VE, et al., 1988, IDENTIFICATION OF THE COAT PROTEIN GENE OF TOMATO GOLDEN MOSAIC-VIRUS, JOURNAL OF GENERAL VIROLOGY, Vol: 69, Pages: 1351-1357, ISSN: 0022-1317
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- Citations: 41
ERDJUMENT H, LANE DA, LOWE GDO, et al., 1988, ANTITHROMBIN GLASGOW - SUBSTITUTION OF ARG393 TO HIS AT THE REACTIVE SITE, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 69, Pages: 121-121, ISSN: 0007-1048
ERDJUMENT H, LANE DA, PANICO M, et al., 1988, SINGLE AMINO-ACID SUBSTITUTIONS IN THE REACTIVE SITE OF ANTITHROMBIN LEADING TO THROMBOSIS - CONGENITAL SUBSTITUTION OF ARGININE-393 TO CYSTEINE IN ANTITHROMBIN NORTHWICK PARK AND TO HISTIDINE IN ANTITHROMBIN GLASGOW, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 263, Pages: 5589-5593, ISSN: 0021-9258
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- Citations: 85
CAIRNS MT, ALVAREZ J, PANICO M, et al., 1987, INVESTIGATION OF THE STRUCTURE AND FUNCTION OF THE HUMAN-ERYTHROCYTE GLUCOSE TRANSPORTER BY PROTEOLYTIC DISSECTION, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 905, Pages: 295-310, ISSN: 0006-3002
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- Citations: 97
YIANGOU Y, DIMARZO V, SPOKES RA, et al., 1987, ISOLATION, CHARACTERIZATION, AND PHARMACOLOGICAL ACTIONS OF PEPTIDE HISTIDINE VALINE 42, A NOVEL PREPROVASOACTIVE INTESTINAL PEPTIDE-DERIVED PEPTIDE, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 262, Pages: 14010-14013, ISSN: 0021-9258
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- Citations: 62
SCHRAG JD, CHENG CHC, PANICO M, et al., 1987, PRIMARY AND SECONDARY STRUCTURE OF ANTIFREEZE PEPTIDES FROM ARCTIC AND ANTARCTIC ZOARCID FISHES, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 915, Pages: 357-370, ISSN: 0006-3002
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- Citations: 34
ERDJUMENT H, LANE DA, IRELAND H, et al., 1987, FORMATION OF A COVALENT DISULFIDE-LINKED ANTITHROMBIN-ALBUMIN COMPLEX BY AN ANTITHROMBIN VARIANT, ANTITHROMBIN NORTHWICK PARK, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 262, Pages: 13381-13384, ISSN: 0021-9258
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- Citations: 46
ERDJUMENT H, LANE DA, FLYNN AM, et al., 1987, ANTITHROMBIN-III NORTHWICK-PARK - CHARACTERIZATION OF AN INACTIVE HIGH MW COMPLEX WITH INCREASED AFFINITY FOR HEPARIN, THROMBOSIS AND HAEMOSTASIS, Vol: 58, Pages: 427-427, ISSN: 0340-6245
DUNMORE SJ, PANICO M, ETIENNE AT, et al., 1987, THE EFFECTS OF STRUCTURAL MODIFICATIONS ON THE INSULIN-RELEASING ACTIVITY OF BETA-CELL-TROPIN, BIOCHEMICAL JOURNAL, Vol: 244, Pages: 797-800, ISSN: 0264-6021
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- Citations: 9
YIANGOU Y, DIMARZO V, PANICO M, et al., 1986, PURIFICATION AND SEQUENCE-ANALYSIS OF A NOVEL 42-AMINO ACID PEPTIDE (PHV-42) THAT IS CONTAINED IN PREPRO-VIP, REGULATORY PEPTIDES, Vol: 15, Pages: 199-199, ISSN: 0167-0115
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- Citations: 2
CAIRNS MT, PANICO M, MORRIS HR, et al., 1986, ISOLATION AND CHARACTERIZATION OF TRYPTIC FRAGMENTS FROM THE HUMAN-ERYTHROCYTE GLUCOSE-TRANSPORT PROTEIN, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 14, Pages: 747-748, ISSN: 0300-5127
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- Citations: 8
TIPPINS JR, DIMARZO V, PANICO M, et al., 1986, INVESTIGATION OF THE STRUCTURE ACTIVITY RELATIONSHIP OF HUMAN CALCITONIN GENE-RELATED PEPTIDE (CGRP), BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 134, Pages: 1306-1311, ISSN: 0006-291X
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- Citations: 72
Southan C, Thompson E, Panico M, et al., 1985, Characterization of peptides cleaved by plasmin from the C-terminal polymerization domain of human fibrinogen., J Biol Chem, Vol: 260, Pages: 13095-13101, ISSN: 0021-9258
The C-terminal region of the fibrinogen gamma chain is known to participate in several functional interactions including fibrin polymerization. This part of the molecule is retained on the gamma chain of fragment D (FgD) when fibrinogen is digested by plasmin in the presence of calcium to produce the fragment D-fragment E (FgD X FgE) complex but is lost if FgD is prepared in the absence of calcium. In an attempt to characterize the C-terminal polymerization domain we have used three techniques to examine this further degradation of FgD following the addition of EDTA and plasmin. Analysis of the digestion by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a progressive cleavage of the gamma chain to two small remnants. The polymerization-inhibitory activity of the whole digest was studied using acid-solubilized fibrin. A progressive loss of inhibitory activity was associated with gamma chain shortening, reaching greater than a 120-fold reduction at the end of digestion. The cleavage of peptides was followed by reverse-phase high performance liquid chromatography and the release of a characteristic peptide triplet was associated with gamma chain cleavage. Manual sequencing, amino acid analysis, and fast atom bombardment mass spectrometry established the three peptides as gamma 303-356, 357-373, and 374-405. These peptides have sequences in common with those peptides recently reported by other investigators to be potent polymerization inhibitors. However, when a mixture of the three peptides was added in a 200-fold molar excess to polymerizing fibrin, no inhibitory activity could be demonstrated. It is concluded that the C-terminal polymerization domain of fibrinogen may be an extended region which includes the sequence gamma 303-405, when this is contiguous with the remainder of the gamma chain.
GIRGIS SI, MACINTYRE I, TIPPINS J, et al., 1985, DETECTION AND MEASUREMENT OF CGRP-LIKE SUBSTANCE IN MAN, BONE, Vol: 6, Pages: 56-56, ISSN: 8756-3282
MARNELA KM, MORRIS HR, PANICO M, et al., 1985, GLUTAMYL-TAURINE IS THE PREDOMINANT SYNAPTIC TAURINE PEPTIDE, JOURNAL OF NEUROCHEMISTRY, Vol: 44, Pages: 752-754, ISSN: 0022-3042
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- Citations: 40
SOUTHAN C, THOMPSON E, PANICO M, et al., 1985, CHARACTERIZATION OF PEPTIDES CLEAVED BY PLASMIN FROM THE C-TERMINAL POLYMERIZATION DOMAIN OF HUMAN-FIBRINOGEN, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 260, Pages: 3095-3101, ISSN: 0021-9258
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- Citations: 46
MUECKLER M, CARUSO C, BALDWIN SA, et al., 1985, SEQUENCE AND STRUCTURE OF A HUMAN GLUCOSE TRANSPORTER, SCIENCE, Vol: 229, Pages: 941-945, ISSN: 0036-8075
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- Citations: 1431
DUNMORE SJ, BELOFFCHAIN A, PANICO M, et al., 1984, STUDIES ON THE BIOLOGICAL-ACTIVITY OF FRAGMENTS OF BETA-CELL-TROPIN, ACTH22-39, IN THE PERFUSED RAT PANCREAS, DIABETOLOGIA, Vol: 27, Pages: A271-A271, ISSN: 0012-186X
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- Citations: 2
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