Imperial College London
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DrMariaParaskevaidi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Fellow
 
 
 
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Contact

 

m.paraskevaidi

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Athanasiou:2019:10.1136/bmjopen-2018-028008,
author = {Athanasiou, A and Veroniki, A and Efthimiou, O and Kalliala, I and Naci, H and Lever, S and Paraskevaidi, M and Martin-Hirsch, P and Bennett, P and Paraskevaidis, E and Salanti, G and Kyrgiou, M},
doi = {10.1136/bmjopen-2018-028008},
journal = {BMJ Open},
pages = {1--7},
title = {Comparative efficacy and complication rates after local treatment for cervical intra-epithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE Group},
url = {http://dx.doi.org/10.1136/bmjopen-2018-028008},
volume = {9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: Local treatments for cervical intra-epithelial neoplasia (CIN) and microinvasive disease remove or ablate a cone-shaped part of the uterine cervix containing theabnormal cells. A trend towards less radical techniques has raised concerns that this mayadversely impact the rates of precancerous and cancerous recurrence. However, there hasbeen no strong evidence to support such claims. We hereby describe a protocol of asystematic review and network meta-analysis that will update the evidence and compare allrelevant treatments in terms of efficacy and complications.Methods and Analysis: Literature searches in electronic databases (CENTRAL, MEDLINE,EMBASE) or trial registries will identify published and unpublished randomised controlledtrials (RCTs) and cohort studies comparing the efficacy and complications amongst differentexcisional and ablative techniques. The excisional techniques include cold knife, laser orfischer cone, large loop or needle excision of the transformation zone and the ablative radicalpoint diathermy, cryotherapy, cold coagulation or laser ablation. The primary outcome willbe residual/recurrent disease defined as abnormal histology or cytology of any grade, whilesecondary outcomes will include treatment failure rates defined as high-grade histology orcytology, histologically-confirmed CIN1+ or histologically-confirmed CIN2+, HPVpositivity rates, involved margins rates, bleeding and cervical stenosis rates. We will assessthe risk of bias in RCTs and observational studies using tools developed by the CochraneCollaboration. Two authors will independently assess study eligibility, abstract the data, andassess the risk of bias. Random-effects meta-analyses and network meta-analyses will beconducted using the odds ratio for dichotomous outcomes and the mean difference forcontinuous outcomes. The quality of the evidence for the primary outcome will be assessedusing the CINEMA tool.
AU  - Athanasiou,A
AU  - Veroniki,A
AU  - Efthimiou,O
AU  - Kalliala,I
AU  - Naci,H
AU  - Lever,S
AU  - Paraskevaidi,M
AU  - Martin-Hirsch,P
AU  - Bennett,P
AU  - Paraskevaidis,E
AU  - Salanti,G
AU  - Kyrgiou,M
DO  - 10.1136/bmjopen-2018-028008
EP  - 7
PY  - 2019///
SN  - 2044-6055
SP  - 1
TI  - Comparative efficacy and complication rates after local treatment for cervical intra-epithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE Group
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2018-028008
UR  - https://bmjopen.bmj.com/content/9/8/e028008
UR  - http://hdl.handle.net/10044/1/71856
VL  - 9
ER  -
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