Imperial College London
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DrMariaParaskevaidi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Fellow
 
 
 
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Contact

 

m.paraskevaidi

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Paraskevaidi:2020:10.3390/cancers12051256,
author = {Paraskevaidi, M and Morais, CLM and Ashton, KM and Stringfellow, HF and McVey, RJ and Ryan, NAJ and O'Flynn, H and Sivalingam, VN and Kitson, SJ and MacKintosh, ML and Derbyshire, AE and Pow, C and Raglan, O and Lima, KMG and Kyrgiou, M and Martin-Hirsch, PL and Martin, FL and Crosbie, EJ},
doi = {10.3390/cancers12051256},
journal = {Cancers},
pages = {1--17},
title = {Detecting endometrial cancer by blood spectroscopy: a diagnostic cross-sectional study},
url = {http://dx.doi.org/10.3390/cancers12051256},
volume = {12},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Endometrial cancer is the sixth most common cancer in women, with a rising incidence worldwide. Current approaches for the diagnosis and screening of endometrial cancer are invasive, expensive or of moderate diagnostic accuracy, limiting their clinical utility. There is a need for cost-effective and minimally invasive approaches to facilitate the early detection and timely management of endometrial cancer. We analysed blood plasma samples in a cross-sectional diagnostic accuracy study of women with endometrial cancer (n = 342), its precursor lesion atypical hyperplasia (n = 68) and healthy controls (n = 242, total n = 652) using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy and machine learning algorithms. We show that blood-based infrared spectroscopy has the potential to detect endometrial cancer with 87% sensitivity and 78% specificity. Its accuracy is highest for Type I endometrial cancer, the most common subtype, and for atypical hyperplasia, with sensitivities of 91% and 100%, and specificities of 81% and 88%, respectively. Our large-cohort study shows that a simple blood test could enable the early detection of endometrial cancer of all stages in symptomatic women and provide the basis of a screening tool in high-risk groups. Such a test has the potential not only to differentially diagnose endometrial cancer but also to detect its precursor lesion atypical hyperplasia—the early recognition of which may allow fertility sparing management and cancer prevention.
AU  - Paraskevaidi,M
AU  - Morais,CLM
AU  - Ashton,KM
AU  - Stringfellow,HF
AU  - McVey,RJ
AU  - Ryan,NAJ
AU  - O'Flynn,H
AU  - Sivalingam,VN
AU  - Kitson,SJ
AU  - MacKintosh,ML
AU  - Derbyshire,AE
AU  - Pow,C
AU  - Raglan,O
AU  - Lima,KMG
AU  - Kyrgiou,M
AU  - Martin-Hirsch,PL
AU  - Martin,FL
AU  - Crosbie,EJ
DO  - 10.3390/cancers12051256
EP  - 17
PY  - 2020///
SN  - 2072-6694
SP  - 1
TI  - Detecting endometrial cancer by blood spectroscopy: a diagnostic cross-sectional study
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers12051256
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000539246000197&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2072-6694/12/5/1256
UR  - http://hdl.handle.net/10044/1/83496
VL  - 12
ER  -
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