Summary
Professor of Molecular Endocrinology
Research Interests
- Nuclear receptor signalling in cancer, metabolism and reproduction.
- Role of transcriptional cofactors in gene expression.
Membership of Societies
- EMBO member
- Fellow of Academy of Medical Sciences
- Biochemical Society
- Endocrine Society (USA)
- Society for Endocrinology (UK)
Key publications
Nautiyal J, Steel JH, Mane MR, Oduwole O, Poliandri A, Alexi, Wood N, Poutanen M, Zwart W, Stingl J and Parker MG [2013] The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development. 2013 Mar;140(5):1079-89.
Percharde M, Lavial F, Ng JH, Kumar V, Tomaz RA, Martin N, Yeo JC, Gil J, Prabhakar S, Ng HH, Parker MG and Azuara V [2012] Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev. 2012 Oct 15;26(20):2286-98.
Nautiyal J, Steel JH, Rosell MM, Nikolopoulou E, Lee K, Demayo FJ, White R, Richards JS, Parker MG. [2010] The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphirregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary. Endocrinology 151(6):2923-32
Morganstein DL, Wu P, Mane MR, Fisk NM, White R and Parker MG. [2010] Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression. Cell Res. Apr;20 (4): 434-44
Seth A, Steel JH, Nichol D, Pocock V, Kumaran MK, Fritah A, Mobberley M, Ryder TA, Rowlerson A, Scott J, Poutanen M, White R and Parker M. [2007] The Transcriptional Corepressor RIP140 Regulates Oxidative Metabolism in Skeletal Muscle. Cell Metab. Sep;6(3):236-45
Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth SM., White R and Parker MG. [2007] RIP140 directs histone modifications and de novo DNA methylation activity to silence Ucp1 gene expression in white adipocytes. EMBO J 26, 4831-40
Leonardsson G, Steel J, Christian M, Pocock V, Debevec D, Bell J, So P-W, Medina Gomez G, Vidal-Puig A, White R and Parker MG. [2004] The Nuclear Receptor Corepressor RIP140 Regulates Fat accumulation, Proc. Nat. Acad. Sci. 101, 8437-8442
White R, Leonardsson G, Roswell I, Jacobs MA, Milligan S and Parker M. [2000] The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility. Nat Med. Dec;6(12):1368-74
Heery DM, Kalkhoven E, Hoare S and Parker MG. [1997] A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387, 733-736
Cavailles V, Dauvois S, L’Horset F, Lopez G, Hoare S, Kushner PJ, and Parker MG. [1995] Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J .14, 3741-3751
Publications
Journals
Barneda D, Planas-Iglesias J, Gaspar ML, et al., 2015, The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix., Elife, Vol:4, ISSN:2050-084X
Nikolopoulou E, Papacleovoulou G, Jean-Alphonse F, et al., 2014, Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential, Journal of Lipid Research, Vol:55, ISSN:0022-2275, Pages:2479-2490
Rosell M, Nevedomskaya E, Stelloo S, et al., 2014, Complex Formation and Function of Estrogen Receptor alpha in Transcription Requires RIP140, Cancer Research, Vol:74, ISSN:0008-5472, Pages:5469-5479
Rosell M, Kaforou M, Frontini A, et al., 2014, Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice, American Journal of Physiology-endocrinology and Metabolism, Vol:306, ISSN:0193-1849, Pages:E945-E964
Kiskinis E, Chatzeli L, Curry E, et al., 2014, RIP140 Represses the "Brown-in-White" Adipocyte Program Including a Futile Cycle of Triacyclglycerol Breakdown and Synthesis, Molecular Endocrinology, Vol:28, ISSN:0888-8809, Pages:344-356