Imperial College London
Alternate

ProfessorMalcolmParker

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.parker Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barneda:2015:10.7554/eLife.07485,
author = {Barneda, D and Planas-Iglesias, J and Gaspar, ML and Mohammadyani, D and Prasannan, S and Dormann, D and Han, GS and Jesch, SA and Carman, GM and Kagan, V and Parker, MG and Ktistakis, NT and Klein-Seetharaman, J and Dixon, AM and Henry, SA and Christian, M},
doi = {10.7554/eLife.07485},
journal = {eLife},
title = {The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix.},
url = {http://dx.doi.org/10.7554/eLife.07485},
volume = {4},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Maintenance of energy homeostasis depends on the highly regulated storage and release of triacylglycerol primarily in adipose tissue, and excessive storage is a feature of common metabolic disorders. CIDEA is a lipid droplet (LD)-protein enriched in brown adipocytes promoting the enlargement of LDs, which are dynamic, ubiquitous organelles specialized for storing neutral lipids. We demonstrate an essential role in this process for an amphipathic helix in CIDEA, which facilitates embedding in the LD phospholipid monolayer and binds phosphatidic acid (PA). LD pairs are docked by CIDEA trans-complexes through contributions of the N-terminal domain and a C-terminal dimerization region. These complexes, enriched at the LD-LD contact site, interact with the cone-shaped phospholipid PA and likely increase phospholipid barrier permeability, promoting LD fusion by transference of lipids. This physiological process is essential in adipocyte differentiation as well as serving to facilitate the tight coupling of lipolysis and lipogenesis in activated brown fat.
AU  - Barneda,D
AU  - Planas-Iglesias,J
AU  - Gaspar,ML
AU  - Mohammadyani,D
AU  - Prasannan,S
AU  - Dormann,D
AU  - Han,GS
AU  - Jesch,SA
AU  - Carman,GM
AU  - Kagan,V
AU  - Parker,MG
AU  - Ktistakis,NT
AU  - Klein-Seetharaman,J
AU  - Dixon,AM
AU  - Henry,SA
AU  - Christian,M
DO  - 10.7554/eLife.07485
PY  - 2015///
SN  - 2050-084X
TI  - The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix.
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.07485
UR  - http://hdl.handle.net/10044/1/29231
VL  - 4
ER  -
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