Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Honorary Senior Lecturer



+44 (0)20 3313 8299m.percharde Website




CRB 2006 / 2013Hammersmith HospitalHammersmith Campus






Ext. 38235

Dr Michelle Percharde is an epigenetics and stem cell biologist and head of the Chromatin and Development Group at the MRC LMS.

Her work focuses on understanding the interplay between transposable elements, chromatin regulation and cell fate choices during early development.

She carried out her undergraduate degree in Biochemistry at the University of Cambridge and PhD in reprogramming and nuclear receptors at Imperial College, London. In 2013, she moved to UCSF in San Francisco, USA, and was awarded a CIRM postdoctoral fellowship to carry out her postdoctoral training with Prof. Miguel Ramalho-Santos. She moved to Imperial College as an independent fellow in 2018.

Full publication list



Azuara V, Mau KHT, Karimlou D, et al., 2022, Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development, Nature Communications, Vol:13, ISSN:2041-1723

Xie SQ, Leeke BJ, Whidling C, et al., 2021, Nucleolar-based <i>Dux</i> repression is essential for 2-cell stage exit

Percharde M, Lin C-J, Ramalho-Santos M, 2021, Depletion of nuclear LINE1 RNA in mouse ESCs and embryos, Star Protocols, Vol:2, ISSN:2666-1667

Lu JY, Chang L, Li T, et al., 2021, Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome, Cell Research, Vol:31, ISSN:1001-0602, Pages:613-630

Kuwahara A, Lewis AE, Coombes C, et al., 2020, Delineating the early transcriptional specification of the mammalian trachea and esophagus, Elife, Vol:9, ISSN:2050-084X

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