Imperial College London
Portrait Picture

Dr Margarita Pons-Salort

Faculty of Medicine, School of Public Health

Sir Henry Dale Fellow (ARF)
 
 
 
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Contact

 

m.pons-salort Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2015:10.1038/srep11293,
author = {de, Celles MD and Pons-Salort, M and Varon, E and Vibet, M-A and Ligier, C and Letort, V and Opatowski, L and Guillemot, D},
doi = {10.1038/srep11293},
journal = {Scientific Reports},
pages = {1--11},
title = {Interaction of vaccination and reduction of antibiotic use drives unexpected increase of pneumococcal meningitis},
url = {http://dx.doi.org/10.1038/srep11293},
volume = {5},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Antibiotic-use policies may affect pneumococcal conjugate-vaccine effectiveness. The reported increase of pneumococcal meningitis from 2001 to 2009 in France, where a national campaign to reduce antibiotic use was implemented in parallel to the introduction of the 7-valent conjugate vaccine, provides unique data to assess these effects. We constructed a mechanistic pneumococcal transmission model and used likelihood to assess the ability of competing hypotheses to explain that increase. We find that a model integrating a fitness cost of penicillin resistance successfully explains the overall and age-stratified pattern of serotype replacement. By simulating counterfactual scenarios of public health interventions in France, we propose that this fitness cost caused a gradual and pernicious interaction between the two interventions by increasing the spread of nonvaccine, penicillin-susceptible strains. More generally, our results indicate that reductions of antibiotic use may counteract the benefits of conjugate vaccines introduced into countries with low vaccine-serotype coverages and high-resistance frequencies. Our findings highlight the key role of antibiotic use in vaccine-induced serotype replacement and suggest the need for more integrated approaches to control pneumococcal infections.
AU  - de,Celles MD
AU  - Pons-Salort,M
AU  - Varon,E
AU  - Vibet,M-A
AU  - Ligier,C
AU  - Letort,V
AU  - Opatowski,L
AU  - Guillemot,D
DO  - 10.1038/srep11293
EP  - 11
PY  - 2015///
SN  - 2045-2322
SP  - 1
TI  - Interaction of vaccination and reduction of antibiotic use drives unexpected increase of pneumococcal meningitis
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep11293
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356099400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/srep11293
UR  - http://hdl.handle.net/10044/1/78438
VL  - 5
ER  -
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