Imperial College London
Portrait Picture

Dr Margarita Pons-Salort

Faculty of Medicine, School of Public Health

Sir Henry Dale Fellow (ARF)
 
 
 
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Contact

 

m.pons-salort Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parker:2015:10.1586/14760584.2015.1052800,
author = {Parker, EP and Molodecky, NA and Pons-Salort, M and O'Reilly, KM and Grassly, NC},
doi = {10.1586/14760584.2015.1052800},
journal = {Expert Review of Vaccines},
pages = {1113--1123},
title = {Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame.},
url = {http://dx.doi.org/10.1586/14760584.2015.1052800},
volume = {14},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The polio eradication endgame aims to bring transmission of all polioviruses to a halt. To achieve this aim, it is essential to block viral replication in individuals via induction of a robust mucosal immune response. Although it has long been recognized that inactivated poliovirus vaccine (IPV) is incapable of inducing a strong mucosal response on its own, it has recently become clear that IPV may boost immunity in the intestinal mucosa among individuals previously immunized with oral poliovirus vaccine. Indeed, mucosal protection appears to be stronger following a booster dose of IPV than oral poliovirus vaccine, especially in older children. Here, we review the available evidence regarding the impact of IPV on mucosal immunity, and consider the implications of this evidence for the polio eradication endgame. We conclude that the implementation of IPV in both routine and supplementary immunization activities has the potential to play a key role in halting poliovirus transmission, and thereby hasten the eradication of polio.
AU  - Parker,EP
AU  - Molodecky,NA
AU  - Pons-Salort,M
AU  - O'Reilly,KM
AU  - Grassly,NC
DO  - 10.1586/14760584.2015.1052800
EP  - 1123
PY  - 2015///
SN  - 1744-8395
SP  - 1113
TI  - Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame.
T2  - Expert Review of Vaccines
UR  - http://dx.doi.org/10.1586/14760584.2015.1052800
UR  - http://www.ncbi.nlm.nih.gov/pubmed/26159938
UR  - http://hdl.handle.net/10044/1/25376
VL  - 14
ER  -
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