Imperial College London
Dr Marie-Christine Ramel

DrMarie-ChristineRamel

Faculty of Natural Sciences, Department of Life Sciences

Visiting Researcher
 
 
 
//

Contact

 

+44 (0)20 7594 5405m.ramel

 
 
//

Location

 

6150Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Vereshchagina:2008:10.1242/jcs.035220,
author = {Vereshchagina, N and Ramel, M-C and Bitoun, E and Wilson, C},
doi = {10.1242/jcs.035220},
journal = {J Cell Sci},
pages = {3383--3392},
title = {The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.},
url = {http://dx.doi.org/10.1242/jcs.035220},
volume = {121},
year = {2008}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Inappropriate regulation of the PI3-kinase/PTEN/Akt kinase-signalling cassette, a key downstream target of insulin/insulin-like growth factor signalling (IIS), is associated with several major human diseases such as diabetes, obesity and cancer. In Drosophila, studies have recently revealed that different subcellular pools of activated, phosphorylated Akt can modulate different IIS-dependent processes. For example, a specific pool of activated Akt within the cytoplasm alters aspects of lipid metabolism, a process that is misregulated in both obesity and diabetes. However, it remains unclear how this pool is regulated. Here we show that the protein phosphatase PP2A-B' regulatory subunit Widerborst (Wdb), which coimmunoprecipitates with Akt in vivo, selectively modulates levels of activated Akt in the cytoplasm. It alters lipid droplet size and expression of the lipid storage perilipin-like protein LSD2 in the Drosophila ovary, but not in epithelial cells of the eye imaginal discs. We conclude that isoforms of PP2A-B' can act as subcellular-compartment-specific regulators of PI3-kinase/PTEN/Akt kinase signalling and IIS, potentially providing new targets for modulating individual subcellular pools of activated Akt in insulin-linked disease.
AU  - Vereshchagina,N
AU  - Ramel,M-C
AU  - Bitoun,E
AU  - Wilson,C
DO  - 10.1242/jcs.035220
EP  - 3392
PY  - 2008///
SN  - 0021-9533
SP  - 3383
TI  - The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.
T2  - J Cell Sci
UR  - http://dx.doi.org/10.1242/jcs.035220
UR  - https://www.ncbi.nlm.nih.gov/pubmed/18827008
VL  - 121
ER  -
Download