Publications
50 results found
Shrimpton RE, Butler M, Morel A-S, et al., 2009, CD205 (DEC-205): A recognition receptor for apoptotic and necrotic self, MOLECULAR IMMUNOLOGY, Vol: 46, Pages: 1229-1239, ISSN: 0161-5890
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- Citations: 127
Butler M, Morel A-S, Jordan WJ, et al., 2007, Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation, IMMUNOLOGY, Vol: 120, Pages: 362-371, ISSN: 0019-2805
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- Citations: 51
Tan PH, Yates JB, Xue SA, et al., 2005, Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression, BLOOD, Vol: 106, Pages: 2936-2943, ISSN: 0006-4971
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- Citations: 54
Tan PH, Beutelspacher SC, Xue SA, et al., 2005, Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy, BLOOD, Vol: 105, Pages: 3824-3832, ISSN: 0006-4971
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- Citations: 119
Tan PH, Beutelspacher SC, Wang YH, et al., 2005, Immunolipoplexes: An efficient, non-viral alternative for transfection of human dendritic cells with potential for clinical vaccination., 6th American Transplant Congress, Publisher: BLACKWELL PUBLISHING, Pages: 367-367, ISSN: 1600-6135
Tan PH, Beutelspacher SC, Wang YH, et al., 2005, Immunolipoplexes: An efficient, nonviral alternative for transfection of human dendritic cells with potential for clinical vaccination, MOLECULAR THERAPY, Vol: 11, Pages: 790-800, ISSN: 1525-0016
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- Citations: 46
Kokkinopoulos I, Jordan WJ, Ritter MA, 2005, Toll-like receptor mRNA expression patterns in human dendritic cells and monocytes, MOLECULAR IMMUNOLOGY, Vol: 42, Pages: 957-968, ISSN: 0161-5890
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- Citations: 71
Tan PH, Herrera OB, Yates J, et al., 2005, Creation of tolerogenic antigen presenting cells via intracellular CTLA4: a novel strategy with potential clinical utility in transplantation, Annual Meeting of the Association-of-Surgeons-of-Great-Britian-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 72-72, ISSN: 0007-1323
Tan PH, Xue SA, Wang YH, et al., 2005, Modulation of human dendritic cell function following viral vectors: implications for gene therapy in vaccination, Annual Meeting of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: OXFORD UNIV PRESS, Pages: 134-134, ISSN: 0007-1323
Jordan WJ, Brookes PA, Szydlo RM, et al., 2004, IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation, BLOOD, Vol: 103, Pages: 717-724, ISSN: 0006-4971
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- Citations: 37
Scupoli MT, Vinante F, Krampera M, et al., 2003, Thymic epithelial cells promote survival of human T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7, HAEMATOLOGICA, Vol: 88, Pages: 1229-1237, ISSN: 0390-6078
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- Citations: 24
Tan PH, Yates J, Xue S, et al., 2003, Prevention of co-stimulation molecule expression using intracellular CTLA4: a novel strategy for induction of T cell anergy, 7th Congress of the International-Xenotransplantation-Association, Publisher: BLACKWELL MUNKSGAARD, Pages: 531-531, ISSN: 0908-665X
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- Citations: 1
Blackburn CC, Manley NR, Palmer DB, et al., 2002, One for all and all for one: thymic epithelial stem cells and regeneration, TRENDS IN IMMUNOLOGY, Vol: 23, Pages: 391-395, ISSN: 1471-4906
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- Citations: 54
De Lorenzo C, Palmer DB, Piccoli R, et al., 2002, A new human antitumor immunoreagent specific for ErbB2, CLINICAL CANCER RESEARCH, Vol: 8, Pages: 1710-1719, ISSN: 1078-0432
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- Citations: 46
Solomou K, Ritter MA, Palmer DB, 2002, Somatostatin is expressed in the murine thymus and enhances thymocyte development, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1550-1559, ISSN: 0014-2980
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- Citations: 36
Jordan WJ, Ritter MA, 2002, Optimal analysis of composite cytokine responses during alloreactivity, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 260, Pages: 1-14, ISSN: 0022-1759
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- Citations: 28
Scupoli MT, Vinante F, Vincenzi C, et al., 2001, Bone marrow-, but not thymus-, derived stromal cells inhibit spontaneous apoptosis and induce proliferation in blasts of T-lineage ALL., BLOOD, Vol: 98, Pages: 81A-81A, ISSN: 0006-4971
Freysdottir J, Ritter MA, 2001, Antibodies to human thymic epithelium form part of the murine autoreactive repertoire., Dev Immunol, Vol: 8, Pages: 75-93, ISSN: 1044-6672
Monoclonal antibody (mAb) MR6 recognises a 200 kDa glycoprotein, gp200-MR6, which is expressed at high levels on the surface of human thymic cortical epithelium. In order to produce further mAbs against the gp200-MR6 molecule, mice were immunised with purified human gp200-MR6, hybridomas produced and supernatants screened for MR6-like reactivity on human thymic sections. Surprisingly this conventional hybridoma technique failed to produce stable hybridoma cells producing MR6-like antibodies. However, antibodies with specificities other than MR6-like were obtained. Three such antibodies (1B2, 3A3 and 4B3) were analysed further. Expression of 1B2-antigen, 3A3-antigen and 4B3-antigen was analysed on skin, tonsil and thymic sections, on cultured thymic epithelial cells (TEC), thymocytes and peripheral blood mononuclear cells (PBMC), and found to be expressed by both lymphocytes and epithelial cell populations. Furthermore, the antigens were also expressed on mouse thymic epithelial cells. The regulation of expression of these antigens was analysed following mitogen or cytokine stimulation of PBMC and cultured TEC, respectively. Expression on T cells was clearly affected by mitogens that mimic activation through the T cell receptor and expression on cultured TEC was affected by T cell-derived cytokines. Thus, the shared epithelial-lymphocyte molecules identified in this study may play a role in the cross-talk between the developing thymocytes and their epithelial microenvironment. The production of mAbs with specificities other than that of purified gp200-MR6 indicates that a wide range of B cells with specificity for components of the human thymic microenvironment exist in the normal mouse. These may detect epitopes that are shared with common pathogens to which the animals are exposed. Alternatively, they may be autoreactive B cells that are normally silent in the absence of T cell help. This help may be provided by T cells specific for human gp200-MR6, or nonspecifica
Johns M, George AJT, Ritter MA, 2000, In vivo selection of sFv from phage display libraries, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 239, Pages: 137-151, ISSN: 0022-1759
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- Citations: 37
Midulla M, Verma R, Pignatelli M, et al., 2000, Source of oncofetal ED-B-containing fibronectin: Implications of production by both tumor and endothelial cells, CANCER RESEARCH, Vol: 60, Pages: 164-169, ISSN: 0008-5472
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- Citations: 61
Palmer DB, Solomou A, Ritter MA, 2000, Functional analysis of the thymic microenvironment using recombinant single chain antibodies, Meeting on New Horizons for Phage Antibody Display Technology, Publisher: HINDAWI LTD, Pages: 69-69, ISSN: 0278-0240
Ritter MA, 2000, Polyclonal and monoclonal antibodies., Methods Mol Med, Vol: 40, Pages: 23-34, ISSN: 1543-1894
The breadth of repertoire yet beautiful specificity of the antibody response is the key to its physiological efficacy in vivo; it also underpins the attractiveness of antibodies as laboratory and clinical reagents. One aspect of the body's reaction to invasion by a microorganism is the activation and clonal expansion of antigen-reactive B lymphocytes. Once these have matured into plasma cells, each clone of cells will secrete its own unique specificity of antibody-thus, the invading pathogen will be met by a barrage of antibody molecules capable of binding to many different sites on its surface. Such a polyclonal response, whose range of specificities and affinities can shift with time, is ideal for combatting infection, and indeed for certain laboratory applications (such as secondary reagents for immunoassay); however, in many experimental and clinical situations the ability to have an unlimited supply of a single antibody that is clearly defined and of reproducible specificity and affinity is of greater value. To produce such a reagent it is necessary to isolate and culture a single clone of B lymphocytes secreting antibody of the appropriate characteristics-that is, to produce a monoclonal antibody (mAb).
Howard JK, Lord GM, Matarese G, et al., 1999, Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in <i>ob</i>/<i>ob</i> mice, JOURNAL OF CLINICAL INVESTIGATION, Vol: 104, Pages: 1051-1059, ISSN: 0021-9738
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- Citations: 428
Ritter MA, Palmer DB, 1999, The human thymic microenvironment: new approaches to functional analysis, SEMINARS IN IMMUNOLOGY, Vol: 11, Pages: 13-21, ISSN: 1044-5323
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- Citations: 41
Palmer DB, Crompton T, Marandi MB, et al., 1999, Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development, IMMUNOLOGY, Vol: 96, Pages: 236-245, ISSN: 0019-2805
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- Citations: 7
Imami N, Ladyman HM, Vincents B, et al., 1998, K21-antigen: a molecule shared by the microenvironments of the human thymus and germinal centers, Developmental Immunology, Vol: 6, Pages: 41-52, ISSN: 1044-6672
The mouse IgG1 monoclonal antibody (mAb) K21 recognizes a 230-kD molecule (K21-Ag) on Hassall's corpuscles in the human thymus. This mAb also stains cultured thymic epithelial cells as well as other epithelial cell lines, revealing a predominant intracellular localization. Further analysis with mAb K21 on other lymphoid tissues showed that it also stains cells within the germinal centers of human tonsils, both lymphoid (B) cells and some with the appearance of follicular dendritic cells. Double immunostaining of tonsil sections shows that K21-Ag is not expressed by T cells, whereas staining with anti-CD22 and -CD23 mAb revealed some doublepositive cells. A subpopulation of the lymphoid cells express the K21-Ag much more strongly. This K21++/CD23++ subpopulation of cells is localized in the apical light zone of germinal centers, suggesting that K21-Ag may be an important marker for the selected centrocytes within germinal centers and may play a role in B-cell selection and/or development of B-cell memory. Flow cytometric analysis showed that K21-Ag is expressed on the surface of a very low percentage of thymocytes, tonsillar lymphocytes, and peripheral blood mononuclear cells. Analysis of purified/separated tonsillar T and B lymphocytes showed that T cells do not express the K21-Ag; in contrast, B cells express low levels of the K21-Ag, and this together with CD23 is upregulated after mitogenic stimulation. Our data therefore raise the possibility that the K2l- Ag may play a role in B-lymphocyte activation/selection.
McKay PF, Imami N, Johns M, et al., 1998, The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 28, Pages: 4071-4083, ISSN: 0014-2980
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- Citations: 33
Imami N, Brookes PA, Lombardi G, et al., 1998, Association between interleukin-4-producing T lymphocyte frequencies and reduced risk of graft-versus-host disease, TRANSPLANTATION, Vol: 65, Pages: 979-988, ISSN: 0041-1337
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- Citations: 19
Almarri A, El Dwick N, Al Kabi S, et al., 1998, Interferon-α therapy in HCV hepatitis:: HLA phenotype and cirrhosis are independent predictors of clinical outcome, HUMAN IMMUNOLOGY, Vol: 59, Pages: 239-242, ISSN: 0198-8859
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- Citations: 30
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