Imperial College London

DrMaxieRoessler

Faculty of Natural SciencesDepartment of Chemistry

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 9861m.roessler Website

 
 
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Location

 

301AMolecular Sciences Research HubWhite City Campus

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Summary

 

Summary

Please click here for the Roessler group website. 

Redox reactions underpin innumerable chemical reactions and much of the chemistry of life. We investigate how oxidation-state changes govern respiration and photosynthesis and how nature has fine-tuned the redox properties of its many intricate molecular machines. Redox reactions often involve transition metal ions and in the group we examine the properties, structure and bonding of transition-metal centres in these complex enzymes. 

Many redox reactions proceed via radical intermediates and these are, perhaps luckily, often located in mechanistically key locations. We use electron paramagnetic resonance (EPR) spectroscopy as a powerful method for obtaining detailed information on the structure and bonding these ubiquitous spin centres. Electrochemistry on the other hand, in particular film electrochemistry, provides insight into the reactions carried out by these catalysts. We are developing a new method, film-electrochemical EPR, to study the evolution of radicals during a (catalytic) reaction and hence gain detailed mechanistic understanding. 

We are currently advertising for fully funded PhD positions. See here for further details. Application deadline 24/03/2021.  

Biography

Maxie completed her DPhil on EPR spectroscopic investigations of Fe-S cluster relays in enzymes at Oxford in 2012 under the supervision of Prof. Fraser Armstrong FRS, started her independent career at Queen Mary University of London in 2013 and moved to Imperial College in April 2019.

She leads an £2.3M EPSRC strategic equipment project, establishing a Centre of Pulse ESR spectroscopy (PEPR) at Imperial College, of which she is the Director. She is passionate about contributing to the EPR community internationally and is currently Vice President (for Europe) of the International ESR Society

Maxie's group has contributed to numerous outreach activities, including the Imperial Lates, the Invention Rooms at White City, as well as the Great Exhibition Road Festival.

Maxie has two children, born in 2013 and 2018. 

Publications

Journals

Hameedi MA, Grba DN, Richardson KH, et al., 2021, A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I., J Biol Chem

Eisermann J, Seif-Eddine M, Roessler MM, 2021, Insights into metalloproteins and metallodrugs from electron paramagnetic resonance spectroscopy., Curr Opin Chem Biol, Vol:61, Pages:114-122

Šimėnas M, O’Sullivan J, Zollitsch CW, et al., 2021, A sensitivity leap for X-band EPR using a probehead with a cryogenic preamplifier, Journal of Magnetic Resonance, Vol:322, ISSN:1090-7807, Pages:1-7

Bridges HR, Fedor JG, Blaza JN, et al., 2020, Structure of inhibitor-bound mammalian complex I, Nature Communications, Vol:11, ISSN:2041-1723

Bajada MA, Roy S, Warnan J, et al., 2020, A Precious-Metal-Free Hybrid Electrolyzer for Alcohol Oxidation Coupled to CO<inf>2</inf>-to-Syngas Conversion, Angewandte Chemie, Vol:132, ISSN:0044-8249, Pages:15763-15771

More Publications