Publications
150 results found
Wahle T, Sastre M, Thal D, et al., 2006, Expression of GGA1 is altered in Alzheimer’s disease and regulates the generation of amyloid-b peptide., Alzheimer’s disease and related disorders
Sastre M, Walter J, Klockgether T, et al., 2006, Stimulation with norepinephrine induces a reduction of amyloid-beta levels in neuronal cells under inflammatory conditions, 10th International Conference on Alzheimer’s disease and related disorders
Heneka MT, Ramanathan M, Jackobs AH, et al., 2006, Locus ceruleus degeneration promotes Alzheimer pathogenesis in APP23 transgenic mice., J. Neurosci., Vol: 26
Heneka MT, Leimer U, Van Leuven F, et al., 2006, Differential regulation of microglial cytokine production, phagocytosis and migration by norepinephrine: how Locus ceruleus degeneration affects Alzheimer’s disease., Alzheimer’s disease and related disorders
Grommes C, Landreth G, Sastre M, et al., 2006, Inhibition of in vivo glioma growth and invasion by PPARγ agonist treatment, Mol. Pharmacol., Vol: 70, Pages: 1524-1533
Wahle T, Thal DT, Sastre M, et al., 2006, GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid {beta}-Peptide., J. Neurosci., Vol: 26, Pages: 12838-12846
Bilkei-Gorzo A, Racz I, Valverde O, et al., 2005, Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors., Proc Natl Acad Sci U S A, Vol: 102, Pages: 15670-15675, ISSN: 0027-8424
The molecular mechanisms contributing to the normal age-related decline of cognitive functions or to pathological learning and memory impairment are largely unknown. We demonstrate here that young mice (6-7 weeks) with a genetic deletion of the cannabinoid CB1 receptor performed as well as WT mice, or often better, in a number of learning and memory paradigms, including animal models of skill-learning, partner recognition, and operant conditioning. In contrast, the performance of mature mice (3-5 months) lacking CB1 receptors was much worse than that of age-matched WT animals. In most tests, these mice performed at the same level as old animals (14-17 months), suggesting that the decline in cognitive functions is accelerated in the absence of CB1 receptors. This rapid decline in CB1-deficient animals is accompanied by a loss of neurons in the CA1 and CA3 regions of the hippocampus.
Heneka MT, Sastre M, Dumitrescu-Ozimek L, et al., 2005, Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1-42 levels in APPV717I transgenic mice, BRAIN, Vol: 128, Pages: 1442-1453, ISSN: 0006-8950
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- Citations: 480
Heneka MT, Sastre M, Dumitrescu-Ozimek L, et al., 2005, Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP(V717I) transgenic mice., J. Neuroinflammation, Vol: 2
Semmler A, Okulla T, Sastre M, et al., 2005, Systemic inflammation induces apoptosis with variable vulnerability of different brain regions., J. Chem Neuroanatomy, Vol: 30, Pages: 144-157
Klotz L, Schmidt M, Giese T, et al., 2005, Proinflammatory Stimulation and Pioglitazone Treatment Regulate Peroxisome Proliferator-Activated Receptorγ Levels in Peripheral Blood Mononuclear Cells from Healthy Controls and Multiple Sclerosis Patients, J. Immunology, Vol: 175, Pages: 4948-4955
Sastre M, Calero M, Pawlik M, et al., 2004, Binding of cystatin C to Alzheimer's amyloid β inhibits in vitro amyloid fibril formation, NEUROBIOLOGY OF AGING, Vol: 25, Pages: 1033-1043, ISSN: 0197-4580
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- Citations: 124
Pawlik M, Sastre M, Calero M, et al., 2004, Binding of cystatin C to amyloid beta inhibits amyloid fibril formation, 9th International Conference on Alzheimers Disease and Related Disorders, Publisher: ELSEVIER SCIENCE INC, Pages: S241-S241, ISSN: 0197-4580
Sastre M, Dewachter I, Rosen E, et al., 2004, Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists modulate immunostimulated processing of app through regulation of β-secretase (BACE), 9th International Conference on Alzheimers Disease and Related Disorders, Publisher: ELSEVIER SCIENCE INC, Pages: S533-S533, ISSN: 0197-4580
Dehmer T, Heneka MT, Sastre M, et al., 2004, Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with IkappaBalpha induction and block of NFkappaB and iNOS activation, J. Neurochem., Vol: 88, Pages: 494-505
Schmidt S, Moric E, Landreth GE, et al., 2004, Anti-inflammatory and antiproliferative actions of PPAR-{gamma} agonists on T lymphocytes derived from MS patients, J. Leukoc. Biol., Vol: 75, Pages: 478-485
Sastre M, Dewachter I, Rosen E, et al., 2004, Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) agonists modulate immunostimulated processing of APP through regulation of beta-secretase (BACE)., Alzheimer’s disease and related disorders
Pawlik M, Sastre M, Calero M, et al., 2004, Binding of Cystatin C to amyloid beta inhibits amyloid beta formation, Alzheimer’s disease and related disorders
Pawlik M, Sastre M, Calero M, et al., 2004, Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide, 13th Annual Summer Neuropeptides Conference, Publisher: HUMANA PRESS INC, Pages: 13-18, ISSN: 0895-8696
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- Citations: 22
Pawlik M, Sastre M, Mathews PM, et al., 2004, Overexpression of human cystatin C in transgenic mice does not affect endogenous amyloid β production, J. Molec. Neurosci., Vol: 22, Pages: 13-18
Ramanathan M, Dumitrescu-Ozimek L, Sastre M, et al., 2003, Locus ceruleus cell death and noradrenaline depletion augments learning and memory deficit in APP2576 transgenic mice, Joint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, Publisher: BLACKWELL PUBLISHING LTD, Pages: 102-102, ISSN: 0022-3042
Sastre M, Dewachter I, Rosen E, et al., 2003, Role of PPARγ on amylold-β generation, Joint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, Publisher: BLACKWELL PUBLISHING LTD, Pages: 98-98, ISSN: 0022-3042
Sastre M, Dewachter I, Landreth GE, et al., 2003, Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β-secretase, JOURNAL OF NEUROSCIENCE, Vol: 23, Pages: 9796-9804, ISSN: 0270-6474
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- Citations: 311
Klotz L, Sastre M, Kreutz A, et al., 2003, Noradrenaline induces expression of Peroxisome Proliferator Activated Receptor gamma in murine primary astrocytes and neurons, J. Neurochem, Vol: 86, Pages: 907-916
Steiner H, Sastre M, Multhaup G, et al., 2002, A presenilin dependent S3-like γ-secretase cleavage of the β-Amyloid precursor protein, 17th Ipsen Foundation Colloque on Medicine and Research on Alzheimers Disease, Publisher: SPRINGER-VERLAG BERLIN, Pages: 59-61, ISSN: 0945-6066
Steiner H, Sastre M, Multhaup G, et al., 2002, Presenilin dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of notch, 5th International Conference on the Progress in Alzheimers and Parkinsons Disease/9th International Catecholamine Symposium, Publisher: KLUWER ACADEMIC/PLENUM PUBL, Pages: 91-94, ISSN: 0099-9962
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- Citations: 1
Sastre M, Steiner H, Fuchs K, et al., 2001, Presenilin dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch, EMBO REPORTS, Vol: 2, Pages: 835-841, ISSN: 1469-221X
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- Citations: 415
Sastre M, Guimon J, Garcia-Sevilla JA, 2001, Relationships between β- and α2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide., Brain Res., Vol: 898, Pages: 242-255
Levy E, Sastre M, Kumar A, et al., 2001, Codeposition of cystatin C with amyloid-β protein in the brain of Alzheimer's disease patients, J. Neuropath. Exp. Neurol., Vol: 60, Pages: 94-104
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