Imperial College London
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ProfessorMagdalenaSastre

Faculty of Medicine, Department of Brain Sciences

Professor in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 6673m.sastre

 
 
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Location

 

406Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mirzaei:2022:10.2174/1567205018666211029164106,
author = {Mirzaei, N and Davis, N and Chau, TW and Sastre, M},
doi = {10.2174/1567205018666211029164106},
journal = {Current Alzheimer Research},
pages = {1--15},
title = {Astrocyte reactivity in Alzheimer’s disease; therapeutic opportunities to promote repair},
url = {http://dx.doi.org/10.2174/1567205018666211029164106},
volume = {19},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly in Alzheimer’s disease (AD), with the prominent presence of reactive astrocytes surrounding amyloid β- plaques, together with activated microglia.  Reactive astrogliosis, implying morphological and molecular transformations in astrocytes, seems to precede neurodegeneration, suggesting a role in the development of the disease. Single-cell transcriptomics have recently demonstrated that astrocytes from AD brains are different from “normal” healthy astrocytes, showing dysregulations in areas such as neurotransmitter recycling, including glutamate and GABA, and impaired homeostatic functions. However, recent data suggests that the ablation of astrocytes in mouse models of amyloidosis results in an increase in amyloid pathology as well as in the inflammatory profile and reduced synaptic density, indicating that astrocytes mediate neuroprotective effects. The idea that interventions targeting astrocytes may have great potential for AD has therefore emerged, supported by a range of drugs and stem cell transplantation studies that have successfully shown a therapeutic effect in mouse models of AD. In this article, we review the latest reports on the role and profile of astrocytes in AD brains and how manipulation of astrocytes in animal models has paved the way for the use of treatments enhancing astrocytic function as future therapeutic avenues for AD.
AU  - Mirzaei,N
AU  - Davis,N
AU  - Chau,TW
AU  - Sastre,M
DO  - 10.2174/1567205018666211029164106
EP  - 15
PY  - 2022///
SN  - 1567-2050
SP  - 1
TI  - Astrocyte reactivity in Alzheimer’s disease; therapeutic opportunities to promote repair
T2  - Current Alzheimer Research
UR  - http://dx.doi.org/10.2174/1567205018666211029164106
UR  - https://www.eurekaselect.com/article/118626
UR  - http://hdl.handle.net/10044/1/90951
VL  - 19
ER  -
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