Imperial College London


Faculty of MedicineDepartment of Brain Sciences

Professor in Molecular Neuroscience



+44 (0)20 7594 6673m.sastre




406Burlington DanesHammersmith Campus





Michel Goedert, University of Cambridge, Animal model of tau pathology, 2018

Roxana Carare, University of Southampton, amyloid and tau drainage mechanisms, 2017

Dr Egle Solito, Centre for Translational Medicine and Therapeutics, The William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry., 2007

Dr. Elena Galea, Universidad Autonoma Barcelona, 2005

Prof. Jochen Walter, University Bonn, 2001

Prof. Fred Van Leuven, University Leuven, 2001

Guest Lectures

The Role of Annexin A1 in the regulation of amyloid-β clearance and neuroinflammation in Alzheimer’s disease, World Congress on Neurology and mental disorders, Rome, Italy, 2018

Astrocytes and their potential neuroprotective role in Alzheimer’s disease, University Bradford, Bradford, UK, 2018

Reducción de la pérdida neuronal, la neuroinflamación yla generación de amiloide. Efectos neuroprotectores del PGC-1α asociados a la reducción de la expresión de BACE 1, University Malaga, Malaga, Spain, 2017

Inflammation as therapeutic target for Alzheimer's disease, Achucarro Institute of Neuroscience, Bilbao, Spain, 2017

The role of astrocytes in memory and neuropathology of Alzheimer’s disease, King's College London, London, 2016

Inflammation as therapeutic target for Alzheimer's disease, King's College London, 2016

The regulatory role of the canonical Wnt/β-catenin pathway in Alzheimer’s disease, University Bonn, Bonn, Germany, 2014

Investigating the link between AD and type 2 diabetes, Dementia National Symposium, Open University, 2013

Regulation of neuroinflammation in Alzheimer’s disease as potential target for therapy, University College London, 2013

Modulating Neuroinflammation in Alzheimer‘s disease, King's College London, 2012

The role and consequences of inflammation in the progression and therapy for Alzheimer‘s disease, Cambridge Centre for Brain Repair. Spring School, Cambridge, 2011

The role of inflammation in Alzheimer‘s disease, University of Newcastle, Newcastle, 2011

Effects of inflammation in Alzheimer's disease progression, University Munich, Munich, Germany, 2009

Molecular mechanisms of inflammation and anti-inflammatory therapy in Alzheimer’s disease., Universidad of Indiana, Indianapolis, USA, 2006

Regulation of BACE by inflammation., Universidad Autonoma Barcelona, Barcelona, Spain, 2006

Influence of inflammation in Alzheimer's disease and potential therapy with anti-inflammatory PPARγ agonists, University Tuebingen, Tuebingen, Germany, 2005

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms, University Leipzig, Leipzig, Germany, 2005

Modulation of glial activation in animal models of Alzheimer's disease, University of Southampton

Research Staff



Hernandez Mir,G




Research Student Supervision


Davis,N, The regulatory mechanisms of gene expression induced by NSAIDs in Alzheimer's disease



Ries,M, The role of annexin A1 in the control of amyloid b clearance and in regulating blood-brain barrier functionality in Alzheimer's disease