Publications
297 results found
El-Helw LM, Seckl MJ, Haynes R, et al., 2005, High-dose chemotherapy and peripheral blood stem cell support in refractory gestational trophoblastic neoplasia, BRITISH JOURNAL OF CANCER, Vol: 93, Pages: 620-621, ISSN: 0007-0920
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- Citations: 36
Palmieri C, Fisher RA, Sebire NJ, et al., 2005, Placental site trophoblastic tumour arising from a partial hydatidiform mole, LANCET, Vol: 366, Pages: 688-688, ISSN: 0140-6736
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- Citations: 31
Sebire NJ, Lindsay I, Fisher RA, et al., 2005, Overdiagnosis of complete and partial hydatidiform mole in tubal ectopic pregnancies, INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, Vol: 24, Pages: 260-264, ISSN: 0277-1691
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- Citations: 39
Dhillon T, Palmieri C, Newlands E, et al., 2005, Whole body positron emission tomography (PET) for the detection of residual disease in gestational trophoblastic tumors (GTTs)., 41st Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: AMER SOC CLINICAL ONCOLOGY, Pages: 481S-481S, ISSN: 0732-183X
Seckl M, Dhillon T, Young AM, et al., 2005, Management and outcome of healthy women with a persistently elevated serum β-hCG., 41st Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: AMER SOC CLINICAL ONCOLOGY, Pages: 475S-475S, ISSN: 0732-183X
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- Citations: 4
Wenzel L, Dogan-Ates A, Habbal R, et al., 2005, Defining and measuring reproductive concerns of female cancer survivors., J Natl Cancer Inst Monogr, Pages: 94-98, ISSN: 1052-6773
Although women diagnosed with cancer during their childbearing years are at significant risk for infertility, we know little about the relationship between infertility and long-term quality of life (QOL). To examine these relationships, we assessed psychosocial and reproductive concerns and QOL in 231 female cancer survivors. Greater reproductive concerns were significantly associated with lower QOL on numerous dimensions (P<.001). In a multiple regression model, social support, gynecologic problems, and reproductive concerns accounted for 63% of the variance in QOL scores. Women who reported wanting to conceive after cancer, but were not able to, reported significantly more reproductive concerns than those who were able to reproduce after cancer (P<.001). These preliminary data suggest that at least for vulnerable subgroups, the issue of reproductive concerns is worthy of additional investigation to assist cancer survivors living with the threat or reality of infertility.
Sebire NJ, Foskett M, Fisher RA, et al., 2005, Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriage, MEDICAL HYPOTHESES, Vol: 64, Pages: 689-693, ISSN: 0306-9877
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- Citations: 14
Sarwar N, Newlands ES, Seckl MJ, 2004, Gestational trophoblastic neoplasia: the management of relapsing patients and other recent advances., Curr Oncol Rep, Vol: 6, Pages: 476-482
The treatment of gestational trophoblastic neoplasia (GTN) represents one of the modern success stories in cancer medicine. Early diagnosis, effective treatments, monitoring of response with a series of serum human chorionic gonadotropin levels, and centralized care have all contributed to this success. Nevertheless, some patients relapse after initial chemotherapy. This review discusses the routine management of GTN and how to treat relapsed disease.
Seckl MJ, Gillmore R, Foskett M, et al., 2004, Routine terminations of pregnancy - should we screen for gestational trophoblastic neoplasia?, LANCET, Vol: 364, Pages: 705-707, ISSN: 0140-6736
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- Citations: 32
Sebire NJ, Rees HC, Peston D, et al., 2004, p57<SUP>KIP2</SUP> immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy, HISTOPATHOLOGY, Vol: 45, Pages: 135-141, ISSN: 0309-0167
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- Citations: 20
Pardo OE, Lesay A, Arcaro A, et al., 2004, Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells (vol 23, pg 7600, 2003), MOLECULAR AND CELLULAR BIOLOGY, Vol: 24, Pages: 6887-6887, ISSN: 0270-7306
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- Citations: 2
Wenzel L, Berkowitz RS, Habbal R, et al., 2004, Predictors of quality of life among long-term survivors of gestational trophoblastic disease, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 49, Pages: 589-594, ISSN: 0024-7758
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- Citations: 17
Seckl MJ, Dhillon T, Dancey G, et al., 2004, Increased gestational age at evacuation of a complete hydatidiform mole - Does it correlate with increased risk of requiring chemotherapy?, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 49, Pages: 527-530, ISSN: 0024-7758
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- Citations: 26
Madhusudan S, Tamir A, Bates N, et al., 2004, A Multicenter phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/<i>neu</i> oncogene, CLINICAL CANCER RESEARCH, Vol: 10, Pages: 2986-2996, ISSN: 1078-0432
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- Citations: 57
Pandian Z, Seckl MJ, Smith R, et al., 2004, Gestational choriocarcinoma: an unusual presentation with response to gemcitabine and surgery, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 111, Pages: 382-384, ISSN: 1470-0328
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- Citations: 13
McMeish I, Kanfer EJ, Haynes R, et al., 2004, Paclitaxel-containing high-dose chemotherapy for relapsed or refractory testicular germ cell tumours, BRITISH JOURNAL OF CANCER, Vol: 90, Pages: 1169-1175, ISSN: 0007-0920
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- Citations: 30
Guppy AE, Nelstrop AE, Foster T, et al., 2004, A phase II study of sequential carboplatin, paclitaxel and topotecan in patients with previously untreated advanced ovarian cancer, BRITISH JOURNAL OF CANCER, Vol: 90, Pages: 810-814, ISSN: 0007-0920
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- Citations: 19
Wallace WHB, Collins MH, D'Angio GJ, et al., 2003, Proceedings of the tumor board of the hospital for sick children, Edinburgh, UK - Infantile choriocarcinoma treated with chemotherapy alone, MEDICAL AND PEDIATRIC ONCOLOGY, Vol: 41, Pages: 550-557, ISSN: 0098-1532
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- Citations: 6
Gaffan J, Holden L, Newlands ES, et al., 2003, Infertility rates following POMB/ACE chemotherapy for male and female germ cell tumours - a retrospective long-term follow-up study, BRITISH JOURNAL OF CANCER, Vol: 89, Pages: 1849-1854, ISSN: 0007-0920
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- Citations: 21
Pardo OE, Lesay A, Arcaro A, et al., 2003, Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells, MOLECULAR AND CELLULAR BIOLOGY, Vol: 23, Pages: 7600-7610, ISSN: 0270-7306
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- Citations: 91
Sebire NJ, Fisher RA, Rees H, et al., 2003, Histomorphological examination and flow cytometric ploidy analysis in the diagnosis of early hydatidiform mole., 2nd Joint Meeting of the British Division of the International-Academy-of-Pathology/185th Meeting of the Pathological-Society-of-Great-Britian-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 52A-52A, ISSN: 0022-3417
Hodges MD, Rees HC, Seckl MJ, et al., 2003, Genetic refinement and physical mapping of a biparental complete hydatidiform mole locus on chromosome 19q13.4, JOURNAL OF MEDICAL GENETICS, Vol: 40, ISSN: 0022-2593
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- Citations: 41
Sebire NJ, Fisher RA, Foskett M, et al., 2003, Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 110, Pages: 22-26, ISSN: 1470-0328
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- Citations: 119
Fisher RA, Hodges MD, Rees HC, et al., 2002, The maternally transcribed gene p57<SUP>KIP2</SUP> (<i>CDNK1C</i>) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles, HUMAN MOLECULAR GENETICS, Vol: 11, Pages: 3267-3272, ISSN: 0964-6906
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- Citations: 109
Arcaro A, Khanzada UK, Vanhaesebroeck B, et al., 2002, Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation, EMBO JOURNAL, Vol: 21, Pages: 5097-5108, ISSN: 0261-4189
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- Citations: 75
Sebire NJ, Foskett M, Paradinas FJ, et al., 2002, Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin, LANCET, Vol: 359, Pages: 2165-2166, ISSN: 0140-6736
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- Citations: 160
Pardo OE, Arcaro A, Seckl MJ, 2002, Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: S120-S120, ISSN: 0007-0920
Papadopoulos AJ, Foskett M, Seckl MJ, et al., 2002, Twenty-five years' clinical experience with placental site trophoblastic tumors, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 47, Pages: 460-464, ISSN: 0024-7758
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- Citations: 138
Newlands ES, Holden L, Seckl MJ, et al., 2002, Management of brain metastases in patients with high-risk gestational trophoblastic tumors, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 47, Pages: 465-471, ISSN: 0024-7758
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- Citations: 62
Guppy AE, Nelstrop A, Agarwal R, et al., 2002, A phase II study of sequential carboplatin, paclitaxel and topotecan in patients with previously untreated advanced ovarian cancer., BRITISH JOURNAL OF CANCER, Vol: 86, Pages: S44-S44, ISSN: 0007-0920
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