Publications
155 results found
Afferson HC, Eleftheriou E, Selkirk ME, et al., 2012, Trichinella spiralis secreted enzymes regulate nucleotide-induced mast cell activation and release of mouse mast cell protease-1, Infection and Immunity, Vol: 80, Pages: 3761-3767
Selkirk ME, Huang SCC, Knox DP, et al., 2012, The development of RNA interference (RNAi) in gastrointestinal nematodes, Parasitology
Matthews JB, Selkirk ME, Krejci E, et al., 2011, A tetrameric acetylcholinesterase from the parasitic nematode Dictyocaulus viviparus associates with the vertebrate tail proteins PRiMA and ColQ (2011)., Molecular and Biochemical Parasitology
White RR, Miyata S, Papa E, et al., 2011, Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner., PLoS Neglected Tropical Diseases, Vol: 5
Rees-Roberts D, Mullen LM, Gounaris K, et al., 2010, Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 40, Pages: 527-532, ISSN: 0020-7519
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- Citations: 17
Huang SCC, Chan DTY, Smyth DJ, et al., 2010, Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum., International Journal for Parasitology, Vol: 40, Pages: 1619-1628
Huang SCC, Chan DTY, Smyth DJ, et al., 2010, Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum., Int J Parasitol, Vol: 40, Pages: 1619-1628
Guiliano DB, Oksov Y, Lustigman S, et al., 2009, Characterisation of novel protein families secreted by muscle stage larvae of <i>Trichinella spiralis</i>, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 39, Pages: 515-524, ISSN: 0020-7519
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- Citations: 12
Ball G, Selkirk ME, Knox DP, 2007, The effect of vaccination with a recombinant <i>Nippostrongylus brasiliensis</i> acetylcholinesterase on infection outcome in the rat, VACCINE, Vol: 25, Pages: 3365-3372, ISSN: 0264-410X
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- Citations: 8
Furze RC, Culley FJ, Selkirk ME, 2006, Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to <i>Trichinella spiralis</i>, MICROBES AND INFECTION, Vol: 8, Pages: 2803-2810, ISSN: 1286-4579
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- Citations: 16
Matthews JB, Lazari O, Davidson AJ, et al., 2006, A tryptophan amphiphilic tetramerization domain-containing acetylcholinesterase from the bovine lungworm, <i>Dictyocaulus viviparus</i>, PARASITOLOGY, Vol: 133, Pages: 381-387, ISSN: 0031-1820
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- Citations: 1
Lazari O, Kipar A, Johnson DR, et al., 2006, Up-regulated expression of the α7 nicotinic acetylcholine receptor subunit on inflammatory infiltrates during <i>Dictyocaulus viviparus</i> infection, PARASITE IMMUNOLOGY, Vol: 28, Pages: 429-437, ISSN: 0141-9838
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- Citations: 1
Selkirk ME, Gounaris K, 2006, Analysis of helminth immunomodulatory molecules by RNA interference, PARASITE IMMUNOLOGY, Vol: 28, Pages: 263-263, ISSN: 0141-9838
Bruce AF, Gares M-P, Selkirk ME, et al., 2006, Functional characterisation of a nematode secreted GM2-activator protein, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 147, Pages: 224-229, ISSN: 0166-6851
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- Citations: 9
Selkirk ME, Maizels RM, 2006, Molecular and cellular biology of helminth parasites IV - Preface, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 36, Pages: 615-616, ISSN: 0020-7519
Furze RC, Hussell T, Selkirk ME, 2006, Amelioration of influenza-induced pathology in mice by coinfection with <i>Trichinella spiralis</i>, INFECTION AND IMMUNITY, Vol: 74, Pages: 1924-1932, ISSN: 0019-9567
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- Citations: 52
Selkirk ME, Lazari O, Hussein AS, et al., 2005, Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions, CHEMICO-BIOLOGICAL INTERACTIONS, Vol: 157, Pages: 263-268, ISSN: 0009-2797
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- Citations: 23
Furze RC, Selkirk ME, 2005, Comparative dynamics and phenotype of the murine immune response to <i>Trichinella spiralis</i> and <i>Trichinella pseudospiralis</i>, PARASITE IMMUNOLOGY, Vol: 27, Pages: 181-188, ISSN: 0141-9838
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- Citations: 17
Gounaris K, Selkirk ME, 2005, Parasite nucleotide-metabolizing enzymes and host purinergic signalling, TRENDS IN PARASITOLOGY, Vol: 21, Pages: 17-21, ISSN: 1471-4922
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- Citations: 38
Selkirk ME, Lazari O, Matthews JB, 2005, Functional genomics of nematode acetylcholinesterases, PARASITOLOGY, Vol: 131, Pages: S3-S18, ISSN: 0031-1820
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- Citations: 37
Gounaris K, Selkirk ME, Sadeghi SJ, 2004, A nucleotidase with unique catalytic properties is secreted by <i>Trichinella spiralis</i>, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 136, Pages: 257-264, ISSN: 0166-6851
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- Citations: 25
Lazari O, Selkirk ME, Ploeger HW, et al., 2004, A putative neuromuscular acetylcholinesterase gene from <i>Dictyocaulus viviparus</i>, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 136, Pages: 313-317, ISSN: 0166-6851
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- Citations: 11
Salinas G, Selkirk ME, Chalar C, et al., 2004, Linked thioredoxin-glutathione systems in platyhelminths, TRENDS IN PARASITOLOGY, Vol: 20, Pages: 340-346, ISSN: 1471-4922
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- Citations: 64
Harcus YM, Parkinson J, Fernandez C, et al., 2004, Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites, Genome Biology, Vol: 5, ISSN: 1474-760X
BackgroundParasitism is a highly successful mode of life and one that requires suites of gene adaptations to permit survival within a potentially hostile host. Among such adaptations is the secretion of proteins capable of modifying or manipulating the host environment. Nippostrongylus brasiliensis is a well-studied model nematode parasite of rodents, which secretes products known to modulate host immunity.ResultsTaking a genomic approach to characterize potential secreted products, we analyzed expressed sequence tag (EST) sequences for putative amino-terminal secretory signals. We sequenced ESTs from a cDNA library constructed by oligo-capping to select full-length cDNAs, as well as from conventional cDNA libraries. SignalP analysis was applied to predicted open reading frames, to identify potential signal peptides and anchors. Among 1,234 ESTs, 197 (~16%) contain predicted 5' signal sequences, with 176 classified as conventional signal peptides and 21 as signal anchors. ESTs cluster into 742 distinct genes, of which 135 (18%) bear predicted signal-sequence coding regions. Comparisons of clusters with homologs from Caenorhabditis elegans and more distantly related organisms reveal that the majority (65% at P < e-10) of signal peptide-bearing sequences from N. brasiliensis show no similarity to previously reported genes, and less than 10% align to conserved genes recorded outside the phylum Nematoda. Of all novel sequences identified, 32% contained predicted signal peptides, whereas this was the case for only 3.4% of conserved genes with sequence homologies beyond the Nematoda.ConclusionsThese results indicate that secreted proteins may be undergoing accelerated evolution, either because of relaxed functional constraints, or in response to stronger selective pressure from host immunity.
Selkirk ME, Hussein AS, Chambers AE, et al., 2004, <i>Trichinella spiralis</i> secretes a homologue of prosaposin, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 135, Pages: 49-56, ISSN: 0166-6851
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- Citations: 11
MILHAUSEN M, NELSON RG, SATHER S, et al., 2004, Identification of a small rna containing the trypanosome spliced leader: A donor of shared 5′ sequences of trypanosomatid mRNAs?, Cell, Vol: 38, Pages: 721-729, ISSN: 0092-8674
The 35 nucleotide spliced leader (SL) sequence is found on the 5′ end of numerous trypanosome mRNAs, yet the tandemly organized reiteration units encoding this leader are not detectably linked to any of these structural genes. Here we report the presence of a class of discrete small SL RNA molecules that are derived from the genomic SL reiteration units of Trypanosoma brucei, Trypanosoma cruzi, and Leptomonas collosoma. These small SL RNAs are 135, 105, and 95 nucleotides, respectively, and contain a 5′-terminal SL or SL-like sequence. S1 nuclease analyses demonstrate that these small SL RNAs are transcribed from continuous sequence within the respective SL reiteration units. With the exception of the SL sequence and a concensus donor splice site immediately following it, these small RNAs are not well conserved. We suggest that the small SL RNAs may function as a donor of the SL sequence in an intermolecular process that places the SL at the 5′ terminus of many trypanosomatid mRNAs.
Selkirk ME, Gounaris K, 2004, Adaptations of parasitic nematodes to mammalian host immunity, 4th International Nematology Congress, Publisher: BRILL, Pages: 589-600, ISSN: 1573-5869
Toutant JP, Massoulié J, Fournier D, et al., 2004, New biosensors for improved detection of environmental and food contamination by anticholinesterase pesticides, Chile, Publisher: MIFAB, Pages: 233-235
Lazari O, Hussein AS, Selkirk ME, et al., 2003, Cloning and expression of two secretory acetylcholinesterases from the bovine lungworm, <i>Dictyocaulus viviparus</i>, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 132, Pages: 83-92, ISSN: 0166-6851
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- Citations: 23
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