Imperial College London
Alternate

Emeritus ProfessorMurraySelkirk

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor in Molecular Parasitology
 
 
 
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Contact

 

+44 (0)20 7594 5214m.selkirk Website

 
 
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Location

 

204Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

155 results found

Tang L, Smith VP, Gounaris K, Selkirk MEet al., 1996, Brugia pahangi: The cuticular glutathione peroxidase (gp29) protects heterologous membranes from lipid peroxidation, EXPERIMENTAL PARASITOLOGY, Vol: 82, Pages: 329-332, ISSN: 0014-4894

Journal article

Yazdanbakhsh M, Sartono E, Selkirk ME, Maizels RMet al., 1996, T-cell activation and antibody responses in lymphatic filariasis, International Conference on T-Cell Subsets and Cytokines Interplay in Infectious Diseases, Publisher: KARGER, Pages: 153-168

Conference paper

YAZDANBAKHSH M, PAXTON WA, BRANDENBURG A, VANREE R, LENS M, PARTONO F, MAIZELS RM, SELKIRK MEet al., 1995, DIFFERENTIAL ANTIBODY ISOTYPE REACTIVITY TO SPECIFIC ANTIGENS IN HUMAN LYMPHATIC FILARIASIS - GP15/400 PREFERENTIALLY INDUCES IMMUNOGLOBULIN-E (IGE), IGG4, AND IGG2, INFECTION AND IMMUNITY, Vol: 63, Pages: 3772-3779, ISSN: 0019-9567

Journal article

TANG L, GOUNARIS K, GRIFFITHS CM, SELKIRK MEet al., 1995, HETEROLOGOUS EXPRESSION AND ENZYMATIC-PROPERTIES OF A SELENIUM-INDEPENDENT GLUTATHIONE-PEROXIDASE FROM THE PARASITIC NEMATODE BRUGIA-PAHANGI, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 18313-18318, ISSN: 0021-9258

Journal article

OU XU, TANG LA, MCCROSSAN M, HENKLEDUHRSEN K, SELKIRK MEet al., 1995, BRUGIA-MALAYI - LOCALIZATION AND DIFFERENTIAL EXPRESSION OF EXTRACELLULAR AND CYTOPLASMIC CUZN SUPEROXIDE DISMUTASES IN ADULTS AND MICROFILARIAE, EXPERIMENTAL PARASITOLOGY, Vol: 80, Pages: 515-529, ISSN: 0014-4894

Journal article

OU XU, THOMAS GR, CHACON MR, TANG LA, SELKIRK MEet al., 1995, BRUGIA-MALAYI - DIFFERENTIAL SUSCEPTIBILITY TO AND METABOLISM OF HYDROGEN-PEROXIDE IN ADULTS AND MICROFILARIAE, EXPERIMENTAL PARASITOLOGY, Vol: 80, Pages: 530-540, ISSN: 0014-4894

Journal article

MAIZELS RM, SARTONO E, KURNIAWAN A, PARTONO F, SELKIRK ME, YAZDANBAKHSH Met al., 1995, T-CELL ACTIVATION AND THE BALANCE OF ANTIBODY ISOTYPES IN HUMAN LYMPHATIC FILARIASIS, PARASITOLOGY TODAY, Vol: 11, Pages: 50-56, ISSN: 0169-4758

Journal article

TANG L, OU X, HENKLEDUHRSEN K, SELKIRK MEet al., 1994, EXTRACELLULAR AND CYTOPLASMIC CUZN SUPEROXIDE DISMUTASES FROM BRUGIA LYMPHATIC FILARIAL NEMATODE PARASITES, INFECTION AND IMMUNITY, Vol: 62, Pages: 961-967, ISSN: 0019-9567

Journal article

YAZDANBAKHSH M, SARTONO E, KRUIZE YCM, KURNIAWAN A, SELKIRK ME, MAIZELS RMet al., 1994, T-CELL RECOGNITION AND ACTIVATION IN FILARIASIS, PARASITE, Vol: 1, Pages: 16-17, ISSN: 1252-607X

Journal article

YAZDANBAKHSH M, SARTONO E, KRUIZE YCM, KURNIAWAN A, VANDERPOUWKRAAN T, VANDERMEIDE PH, SELKIRK ME, PARTONO F, HINTZEN RQ, VANLIER RAW, MAIZELS RMet al., 1993, ELEVATED LEVELS OF T-CELL ACTIVATION ANTIGEN CD27 AND INCREASED INTERLEUKIN-4 PRODUCTION IN HUMAN LYMPHATIC FILARIASIS, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 23, Pages: 3312-3317, ISSN: 0014-2980

Journal article

MAIZELS RM, BLAXTER ML, SELKIRK ME, 1993, FORMS AND FUNCTIONS OF NEMATODE SURFACES, EXPERIMENTAL PARASITOLOGY, Vol: 77, Pages: 380-384, ISSN: 0014-4894

Journal article

SELKIRK ME, GREGORY WF, JENKINS RE, MAIZELS RMet al., 1993, LOCALIZATION, TURNOVER AND CONSERVATION OF GP15/400 IN DIFFERENT STAGES OF BRUGIA-MALAYI, PARASITOLOGY, Vol: 107, Pages: 449-457, ISSN: 0031-1820

Journal article

Selkirk ME, Gregory WF, Jenkins RE, Maizels RMet al., 1993, Localization, turnover and conservation of gp15/400 in different stages of Brugia malayi., Parasitology, Vol: 107 ( Pt 4), Pages: 449-457, ISSN: 0031-1820

The expression of a protein complex designated gp15/400, previously identified via extrinsic iodination of adult Brugia malayi, was examined by labelling all stages found in the mammalian host and immunoprecipitation with a specific antibody raised to a recombinant protein. In this way, gp15/400 could be detected in L3, L4, adult worms and microfilariae recovered from jirds and labelled with Bolton-Hunter reagent. Metabolic labelling indicated that gp15/400 was released into culture medium when adult worms were maintained in vitro, but at a rate slower than that of gp29, the major soluble cuticular glycoprotein. Immuno-electron microscopy showed that the protein complex was broadly distributed in different tissues, although it was not detectable in the cuticle of adult worms. Dense labelling was observed in the matrix of the basal laminae bordering the hypodermis, somatic musculature and oesophagus, and lower but significant labelling was seen in the cells overlying these extracellular matrices. Hybridization of genomic DNA with a cDNA probe encoding gp15/400 indicated that homologous genes were present in Dirofilaria immitis and Acanthocheilonema viteae. The failure to detect related genes in non-filarial nematodes was presumed to be due to divergence beyond the practical limits of detection by nucleic acid probes, as antibody reagents showed that the protein cross-reacted immunologically with ABA-1, a major protein allergen from the body fluid of Ascaris.

Journal article

MCREYNOLDS LA, KENNEDY MW, SELKIRK ME, 1993, THE POLYPROTEIN ALLERGENS OF NEMATODES, PARASITOLOGY TODAY, Vol: 9, Pages: 403-406, ISSN: 0169-4758

Journal article

MAIZELS RM, BUNDY DAP, SELKIRK ME, SMITH DF, ANDERSON RMet al., 1993, IMMUNOLOGICAL MODULATION AND EVASION BY HELMINTH-PARASITES IN HUMAN-POPULATIONS, NATURE, Vol: 365, Pages: 797-805, ISSN: 0028-0836

Journal article

TWEEDIE S, GRIGG ME, INGRAM L, SELKIRK MEet al., 1993, THE EXPRESSION OF A SMALL HEAT-SHOCK PROTEIN HOMOLOG IS DEVELOPMENTALLY-REGULATED IN NIPPOSTRONGYLUS-BRASILIENSIS, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 61, Pages: 149-154, ISSN: 0166-6851

Journal article

PAXTON WA, YAZDANBAKHSH M, KURNIAWAN A, PARTONO F, MAIZELS RM, SELKIRK MEet al., 1993, PRIMARY STRUCTURE OF AND IMMUNOGLOBULIN-E RESPONSE TO THE REPEAT SUBUNIT OF GP15/400 FROM HUMAN LYMPHATIC FILARIAL PARASITES, INFECTION AND IMMUNITY, Vol: 61, Pages: 2827-2833, ISSN: 0019-9567

Journal article

KURNIAWAN A, YAZDANBAKHSH M, VANREE R, AALBERSE R, SELKIRK ME, PARTONO F, MAIZELS RMet al., 1993, DIFFERENTIAL EXPRESSION OF IGE AND IGG4 SPECIFIC ANTIBODY-RESPONSES IN ASYMPTOMATIC AND CHRONIC HUMAN FILARIASIS, JOURNAL OF IMMUNOLOGY, Vol: 150, Pages: 3941-3950, ISSN: 0022-1767

Journal article

YAZDANBAKHSH M, PAXTON WA, KRUIZE YCM, SARTONO E, KURNIAWAN A, WOUT AV, SELKIRK ME, PARTONO F, MAIZELS RMet al., 1993, T-CELL RESPONSIVENESS CORRELATES DIFFERENTIALLY WITH ANTIBODY ISOTYPE LEVELS IN CLINICAL AND ASYMPTOMATIC FILARIASIS, JOURNAL OF INFECTIOUS DISEASES, Vol: 167, Pages: 925-931, ISSN: 0022-1899

Journal article

TWEEDIE S, PAXTON WA, INGRAM L, MAIZELS RM, MCREYNOLDS LA, SELKIRK MEet al., 1993, BRUGIA-PAHANGI AND BRUGIA-MALAYI - A SURFACE-ASSOCIATED GLYCOPROTEIN (GP15-400) IS COMPOSED OF MULTIPLE TANDEMLY REPEATED UNITS AND PROCESSED FROM A 400-KDA PRECURSOR, EXPERIMENTAL PARASITOLOGY, Vol: 76, Pages: 156-164, ISSN: 0014-4894

Journal article

COOKSON E, TANG L, SELKIRK ME, 1993, CONSERVATION OF PRIMARY SEQUENCE OF GP29, THE MAJOR SOLUBLE CUTICULAR GLYCOPROTEIN, IN 3 SPECIES OF LYMPHATIC FILARIAE, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 58, Pages: 155-159, ISSN: 0166-6851

Journal article

ZVELEBIL M, TANG L, COOKSON E, SELKIRK ME, THORNTON JMet al., 1993, MOLECULAR MODELING AND EPITOPE PREDICTION OF GP29 FROM LYMPHATIC FILARIAE, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 58, Pages: 145-153, ISSN: 0166-6851

Journal article

COOKSON E, BLAXTER ML, SELKIRK ME, 1992, IDENTIFICATION OF THE MAJOR SOLUBLE CUTICULAR GLYCOPROTEIN OF LYMPHATIC FILARIAL NEMATODE PARASITES (GP29) AS A SECRETORY HOMOLOG OF GLUTATHIONE-PEROXIDASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 89, Pages: 5837-5841, ISSN: 0027-8424

Journal article

POOLE CB, GRANDEA AG, MAINA CV, JENKINS RE, SELKIRK ME, MCREYNOLDS LAet al., 1992, CLONING OF A CUTICULAR ANTIGEN THAT CONTAINS MULTIPLE TANDEM REPEATS FROM THE FILARIAL PARASITE DIROFILARIA-IMMITIS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 89, Pages: 5986-5990, ISSN: 0027-8424

Journal article

BLACKBURN CC, SELKIRK ME, 1992, CHARACTERIZATION OF THE SECRETORY ACETYLCHOLINESTERASES FROM ADULT NIPPOSTRONGYLUS-BRASILIENSIS, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 53, Pages: 79-88, ISSN: 0166-6851

Journal article

SELKIRK ME, MAIZELS RM, YAZDANBAKHSH M, 1992, IMMUNITY AND THE PROSPECTS FOR VACCINATION AGAINST FILARIASIS, IMMUNOBIOLOGY, Vol: 184, Pages: 263-281, ISSN: 0171-2985

Journal article

BLACKBURN CC, SELKIRK ME, 1992, INACTIVATION OF PLATELET-ACTIVATING-FACTOR BY A PUTATIVE ACETYLHYDROLASE FROM THE GASTROINTESTINAL NEMATODE PARASITE NIPPOSTRONGYLUS-BRASILIENSIS, IMMUNOLOGY, Vol: 75, Pages: 41-46, ISSN: 0019-2805

Journal article

MAIZELS RM, KURNIAWAN A, SELKIRK ME, YAZDANBAKHSH Met al., 1991, IMMUNE-RESPONSES TO FILARIAL PARASITES, IMMUNOLOGY LETTERS, Vol: 30, Pages: 249-254, ISSN: 0165-2478

Journal article

SELKIRK ME, YAZDANBAKHSH M, FREEDMAN D, BLAXTER ML, COOKSON E, JENKINS RE, WILLIAMS SAet al., 1991, A PROLINE-RICH STRUCTURAL PROTEIN OF THE SURFACE SHEATH OF LARVAL BRUGIA FILARIAL NEMATODE PARASITES, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 266, Pages: 11002-11008, ISSN: 0021-9258

Journal article

Selkirk M E, 1991, Structure and biosynthesis of cuticular proteins of filarial parasites, Parasitic Nematodes: Membranes, Antigens and Genes, Editors: Kennedy, London, Publisher: Taylor & Francis, Pages: 27-45

Book chapter

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