Imperial College London
Alternate

Emeritus ProfessorMurraySelkirk

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor in Molecular Parasitology
 
 
 
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Contact

 

+44 (0)20 7594 5214m.selkirk Website

 
 
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Location

 

204Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Roberts:2021:10.1126/sciimmunol.abd0359,
author = {Roberts, LB and Schnoeller, C and Berkachy, R and Darby, M and Pillaye, J and Oudhoff, MJ and Parmar, N and Mackowiak, C and Sedda, D and Quesniaux, V and Ryffel, B and Vaux, R and Gounaris, K and Berrard, S and Withers, DR and Horsnell, WGC and Selkirk, ME},
doi = {10.1126/sciimmunol.abd0359},
journal = {Science Immunology},
title = {Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths},
url = {http://dx.doi.org/10.1126/sciimmunol.abd0359},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Innate lymphoid cells (ILCs) are critical mediators of immunological and physiological responses at mucosal barrier sites. Whereas neurotransmitters can stimulate ILCs, the synthesis of small-molecule neurotransmitters by these cells has only recently been appreciated. Group 2 ILCs (ILC2s) are shown here to synthesize and release acetylcholine (ACh) during parasitic nematode infection. The cholinergic phenotype of pulmonary ILC2s was associated with their activation state, could be induced by in vivo exposure to extracts of Alternaria alternata or the alarmin cytokines interleukin-33 (IL-33) and IL-25, and was augmented by IL-2 in vitro. Genetic disruption of ACh synthesis by murine ILC2s resulted in increased parasite burdens, lower numbers of ILC2s, and reduced lung and gut barrier responses to Nippostrongylus brasiliensis infection. These data demonstrate a functional role for ILC2-derived ACh in the expansion of ILC2s for maximal induction of type 2 immunity.
AU  - Roberts,LB
AU  - Schnoeller,C
AU  - Berkachy,R
AU  - Darby,M
AU  - Pillaye,J
AU  - Oudhoff,MJ
AU  - Parmar,N
AU  - Mackowiak,C
AU  - Sedda,D
AU  - Quesniaux,V
AU  - Ryffel,B
AU  - Vaux,R
AU  - Gounaris,K
AU  - Berrard,S
AU  - Withers,DR
AU  - Horsnell,WGC
AU  - Selkirk,ME
DO  - 10.1126/sciimmunol.abd0359
PY  - 2021///
SN  - 2470-9468
TI  - Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths
T2  - Science Immunology
UR  - http://dx.doi.org/10.1126/sciimmunol.abd0359
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33674321
UR  - https://immunology.sciencemag.org/content/6/57/eabd0359
UR  - http://hdl.handle.net/10044/1/86530
VL  - 6
ER  -
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