Imperial College London
Alternate

Emeritus ProfessorMurraySelkirk

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor in Molecular Parasitology
 
 
 
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Contact

 

+44 (0)20 7594 5214m.selkirk Website

 
 
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Location

 

204Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thawer:2016:10.1371/journal.ppat.1005461,
author = {Thawer, S and Auret, J and Schnoeller, C and Chetty, A and Smith, K and Darby, M and Roberts, L and Mackay, RM and Whitwell, HJ and Timms, JF and Madsen, J and Selkirk, ME and Brombacher, F and Clark, HW and Horsnell, WG},
doi = {10.1371/journal.ppat.1005461},
journal = {PLOS Pathogens},
title = {Surfactant Protein-D Is Essential for Immunity to Helminth Infection.},
url = {http://dx.doi.org/10.1371/journal.ppat.1005461},
volume = {12},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control of nematode infections. An important epithelial product is the collectin Surfactant Protein D (SP-D). We found that SP-D concentrations increased in the lung following Nippostrongylus brasiliensis infection; this increase was dependent on key components of the type 2 immune response. We carried out loss and gain of function studies of SP-D to establish if SP-D was required for optimal immunity to the parasite. N. brasiliensis infection of SP-D-/- mice resulted in profound impairment of host innate immunity and ability to resolve infection. Raising pulmonary SP-D levels prior to infection enhanced parasite expulsion and type 2 immune responses, including increased numbers of IL-13 producing type 2 innate lymphoid cells (ILC2), elevated expression of markers of alternative activation by alveolar macrophages (alvM) and increased production of the type 2 cytokines IL-4 and IL-13. Adoptive transfer of alvM from SP-D-treated parasite infected mice into naïve recipients enhanced immunity to N. brasiliensis. Protection was associated with selective binding by the SP-D carbohydrate recognition domain (CRD) to L4 parasites to enhance their killing by alvM. These findings are the first demonstration that the collectin SP-D is an essential component of host innate immunity to helminths.
AU  - Thawer,S
AU  - Auret,J
AU  - Schnoeller,C
AU  - Chetty,A
AU  - Smith,K
AU  - Darby,M
AU  - Roberts,L
AU  - Mackay,RM
AU  - Whitwell,HJ
AU  - Timms,JF
AU  - Madsen,J
AU  - Selkirk,ME
AU  - Brombacher,F
AU  - Clark,HW
AU  - Horsnell,WG
DO  - 10.1371/journal.ppat.1005461
PY  - 2016///
SN  - 1553-7366
TI  - Surfactant Protein-D Is Essential for Immunity to Helminth Infection.
T2  - PLOS Pathogens
UR  - http://dx.doi.org/10.1371/journal.ppat.1005461
UR  - http://hdl.handle.net/10044/1/29930
VL  - 12
ER  -
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