Imperial College London
Alternate

Emeritus ProfessorMurraySelkirk

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor in Molecular Parasitology
 
 
 
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Contact

 

+44 (0)20 7594 5214m.selkirk Website

 
 
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Location

 

204Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hunt:2016:10.1017/S0031182016001554,
author = {Hunt, VL and Tsai, IJ and Selkirk, ME and Viney, M},
doi = {10.1017/S0031182016001554},
journal = {Parasitology},
pages = {343--358},
title = {The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism.},
url = {http://dx.doi.org/10.1017/S0031182016001554},
volume = {144},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Parasitic nematodes are important and abundant parasites adapted to live a parasitic lifestyle, with these adaptations all aimed at facilitating their survival and reproduction in their hosts. The recently sequenced genomes of four Strongyloides species, gastrointestinal parasites of humans and other animals, alongside transcriptomic and proteomic analysis of free-living and parasitic stages of their life cycles have revealed a number of protein families with a putative role in their parasitism. Many of these protein families have also been associated with parasitism in other parasitic nematode species, suggesting that these proteins may play a fundamental role in nematode parasitism more generally. Here, we review key protein families that have a putative role in Strongyloides' parasitism - acetylcholinesterases, astacins, aspartic proteases, prolyl oligopeptidases, proteinase inhibitors (trypsin inhibitors and cystatins), SCP/TAPS and transthyretin-like proteins - and the evidence for their key, yet diverse, roles in the parasitic lifestyle.
AU  - Hunt,VL
AU  - Tsai,IJ
AU  - Selkirk,ME
AU  - Viney,M
DO  - 10.1017/S0031182016001554
EP  - 358
PY  - 2016///
SN  - 1469-8161
SP  - 343
TI  - The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism.
T2  - Parasitology
UR  - http://dx.doi.org/10.1017/S0031182016001554
UR  - http://hdl.handle.net/10044/1/40853
VL  - 144
ER  -
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