Imperial College London
Alternate

Emeritus ProfessorMurraySelkirk

Faculty of Natural Sciences, Department of Life Sciences

Emeritus Professor in Molecular Parasitology
 
 
 
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Contact

 

+44 (0)20 7594 5214m.selkirk Website

 
 
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Location

 

204Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chatonnet:2017:10.1111/jnc.13990,
author = {Chatonnet, A and Lenfant, N and Marchot, P and Selkirk, ME},
doi = {10.1111/jnc.13990},
journal = {Journal of Neurochemistry},
pages = {73--81},
title = {Natural genomic amplification of cholinesterase genes in animals.},
url = {http://dx.doi.org/10.1111/jnc.13990},
volume = {142},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tight control of the concentration of acetylcholine at cholinergic synapses requires precise regulation of the number and state of the acetylcholine receptors, and of the synthesis and degradation of the neurotransmitter. In particular, the cholinesterase activity has to be controlled exquisitely. In the genome of the first experimental models used (man, mouse, zebrafish and drosophila), there are only one or two genes coding for cholinesterases, whereas there are more genes for their closest relatives the carboxylesterases. Natural amplification of cholinesterase genes was first found to occur in some cancer cells and in insect species subjected to evolutionary pressure by insecticides. Analysis of the complete genome sequences of numerous representatives of the various metazoan phyla show that moderate amplification of cholinesterase genes is not uncommon in molluscs, echinoderms, hemichordates, prochordates or lepidosauria. Amplification of acetylcholinesterase genes is also a feature of parasitic nematodes or ticks. In these parasites, over-production of cholinesterase-like proteins in secreted products and the saliva are presumed to have effector roles related to host infection. These amplification events raise questions about the role of the amplified gene products, and the adaptation processes necessary to preserve efficient cholinergic transmission.
AU  - Chatonnet,A
AU  - Lenfant,N
AU  - Marchot,P
AU  - Selkirk,ME
DO  - 10.1111/jnc.13990
EP  - 81
PY  - 2017///
SN  - 1471-4159
SP  - 73
TI  - Natural genomic amplification of cholinesterase genes in animals.
T2  - Journal of Neurochemistry
UR  - http://dx.doi.org/10.1111/jnc.13990
UR  - http://hdl.handle.net/10044/1/48129
VL  - 142
ER  -
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