Imperial College London

DrMohamedShamji

Faculty of MedicineNational Heart & Lung Institute

Reader in Immunology & Allergy
 
 
 
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Contact

 

+44 (0)20 7594 3476m.shamji99 Website

 
 
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Location

 

Room 111Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

281 results found

Shamji MH, Boyle RJ, Roberts G, 2022, Prize-winning abstracts from BSACI/WAO 2022 meeting, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 830-832, ISSN: 0954-7894

Journal article

Tan TJ, Layhadi JA, Shamji MH, 2022, Mechanisms and biomarkers of subcutaneous immunotherapy and sublingual immunotherapy in allergen immunotherapy., Allergy Asthma Proc, Vol: 43, Pages: 254-259

There are currently no biomarkers that can accurately predict clinical outcomes and segregate responders from nonresponders in allergen immunotherapy (AIT). Therefore, identifying a reliable predictive biomarker is essential to enable clinicians to tailor personalized therapy. New developments in AIT biomarkers are currently being explored, and it would be important to identify key areas of development and their feasibility for use in the clinic. Biomarkers can be categorized broadly into seven domains: (i) Immunoglobulin E (IgE), (ii) IgG and IgA responses, (iii) IgE -facilitated allergen binding/blocking factor, (iv) basophil activation, (v) cytokines and chemokines, (vi) cellular markers, and (vii) in vivo biomarkers. Despite their potential, most biomarkers remain infeasible to be translated to the clinical setting due to requirements of complex instruments such as flow cytometry. The identification of suitable biomarkers remains key in predicting outcomes of AIT and requires more research. Additional exploration into integrative biomarkers may be required.

Journal article

Boyle RJ, Shamji MH, 2022, Clinical and Experimental Allergy boycotts formula advertising, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 828-829, ISSN: 0954-7894

Journal article

Labella M, Céspedes JA, Doña I, Shamji MH, Agache I, Mayorga C, Torres MJet al., 2022, Reply to correspondence: Basophil reactivity to BNT162b2 in COVID-19 convalescence., Allergy, Vol: 77, Pages: 2266-2267

Journal article

Agache I, Palmer E, Sanver D, Kirtland M, Shamji MHet al., 2022, Molecular allergology approach to allergic asthma, MOLECULAR ASPECTS OF MEDICINE, Vol: 85, ISSN: 0098-2997

Journal article

Shamji MH, Boyle RJ, 2022, Biomarkers of airway inflammation and immunotherapy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 726-728, ISSN: 0954-7894

Journal article

Farraia M, Paciencia I, Mendes FC, Rufo JC, Shamji MH, Agache I, Moreira Aet al., 2022, Cost-effectiveness analysis of house dust mite allergen immunotherapy in children with allergic asthma, ALLERGY, ISSN: 0105-4538

Journal article

Boyle RJ, Shamji MH, 2022, Early origins of allergic disease, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 592-594, ISSN: 0954-7894

Journal article

Farraia M, Paciencia I, Castro Mendes F, Cavaleiro Rufo J, Shamji M, Agache I, Moreira Aet al., 2022, Allergen immunotherapy for asthma prevention: A systematic review and meta-analysis of randomized and non-randomized controlled studies, ALLERGY, Vol: 77, Pages: 1719-1735, ISSN: 0105-4538

Journal article

Shamji MH, Boyle RJ, 2022, Immune modulation and the role of innate immune cells in allergy and asthma, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 474-475, ISSN: 0954-7894

Journal article

Jutel M, Torres MJ, Palomares O, Akdis CA, Eiwegger T, Untersmayr E, Barber D, Zemelka-Wiacek M, Kosowska A, Palmer E, Vieths S, Mahler V, Canonica WG, Nadeau K, Shamji MH, Agache I, Akdis M, Khaitov M, Alvarez-Perea A, Alvaro-Lozano M, Atanaskovic-Markovic M, Backer V, Barbaud A, Bavbek S, de Blay F, Bonini M, Bonini S, van Boven JFM, Brockow K, Cazzola M, Chatzipetrou A, Chivato T, Cianferoni A, Corren J, Cristoph-Caubet J, Dunn-Galvin A, Ebisawa M, Firinu D, Gawlik R, Gelincik A, del Giacco S, Mortz CG, Hoffmann HJ, Hoffmann-Sommergruber K, Klimek L, Knol E, Lauerma A, de Llano LP, Matucci A, Meyer R, Moreira A, Morita H, Patil SU, Pfaar O, Popescu F-D, del Pozo V, Price OJ, van Ree R, Fernandez-Rivas M, Rogala B, Romano A, Santos A, Sediva A, Skypala I, Smolinska S, Sokolowska M, Sturm G, Vultaggio A, Walusiak-Skorupa J, Worm Met al., 2022, COVID-19 vaccination in patients receiving allergen immunotherapy (AIT) or biologicals-EAACI recommendations, ALLERGY, ISSN: 0105-4538

Journal article

Bergmann C, Poli A, Agache I, Bianchini R, Bax HJ, Castells M, Crescioli S, Dombrowicz D, Ferastraoaru D, Fiebiger E, Gould HJ, Hartmann K, Izquierdo E, Jordakieva G, Josephs DH, Jutel M, Levi-Schaffer F, de las Vecillas L, Lotze MT, Osborn G, Pascal M, Redegeld F, Rosenstreich D, Roth-Walter F, Schmidt-Weber C, Shamji M, Steveling EH, Turner MC, Untersmayr E, Jensen-Jarolim E, Karagiannis SNet al., 2022, AllergoOncology: Danger signals in allergology and oncology: A European Academy of Allergy and Clinical Immunology (EAACI) Position Paper, ALLERGY, ISSN: 0105-4538

Journal article

Liu Z, Gao P, Shamji MH, 2022, Editorial: The Spectrum of Lymphoid Subsets in Allergic Diseases: Immune Regulation and Immunotherapy, FRONTIERS IN IMMUNOLOGY, Vol: 13, ISSN: 1664-3224

Journal article

Shamji MH, Sharif H, Layhadi JA, Zhu R, Kishore U, Renz Het al., 2022, Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 149, Pages: 791-801, ISSN: 0091-6749

Journal article

Boyle RJ, Krishna MT, Shamji MH, 2022, Allergy in India-a call for submissions, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 364-366, ISSN: 0954-7894

Journal article

Fieten KB, Drijver-Messelink MT, Cogo A, Charpin D, Sokolowska M, Agache I, Taborda-Barata LM, Eguiluz-Gracia I, Braunstahl GJ, Seys SF, van den Berge M, Bloch KE, Ulrich S, Cardoso-Vigueros C, Kappen JH, Ten Brinke A, Koch M, Traidl-Hoffmann C, da Mata P, Prins DJ, Pasmans SGMA, Bendien S, Rukhadze M, Shamji MH, Couto M, Elberink HO, Peroni DG, Piacentini G, Weersink EJM, Bonini M, Rijssenbeek-Nouwens LHM, Akdis CAet al., 2022, Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper, ALLERGY, ISSN: 0105-4538

Journal article

Shamji MH, Boyle RJ, 2022, Biomarker strategies for perioperative hypersensitivity reactions and severe eosinophilic asthma, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 216-218, ISSN: 0954-7894

Journal article

Boyle RJ, Shamji MH, 2022, Milk allergy over-diagnosis, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 52, Pages: 4-6, ISSN: 0954-7894

Journal article

Shamji MH, Boyle RJ, 2021, Allergic diseases and novel targets in allergen immunotherapy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1526-1528, ISSN: 0954-7894

Journal article

Shamji MH, Boyle RJ, Fox AT, 2021, Prize-winning abstracts from BSACI 2021 meeting, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1529-1530, ISSN: 0954-7894

Journal article

Boyle RJ, Shamji MH, 2021, Developments in the field of allergy in 2020 through the eyes of Clinical and Experimental Allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1531-1537, ISSN: 0954-7894

Journal article

Boyle RJ, Shamji MH, 2021, Making causal inferences in allergy epidemiology studies, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1404-1406, ISSN: 0954-7894

Journal article

Labella M, Antonio Cespedes J, Dona I, Shamji MH, Agache I, Mayorga C, Jose Torres Met al., 2021, The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccine, ALLERGY, ISSN: 0105-4538

Journal article

Shamji MH, Larson D, Eifan A, Scadding GW, Qin T, Lawson K, Sever ML, Macfarlane E, Layhadi JA, Wurtzen PA, Parkin R, Sanda S, Harris KM, Nepom GT, Togias A, Durham SRet al., 2021, Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 148, Pages: 1061-+, ISSN: 0091-6749

Journal article

Shamji MH, Boyle RJ, 2021, Unmet needs in food allergy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1258-1259, ISSN: 0954-7894

Journal article

Bousquet J, Agache I, Blain H, Jutel M, Ventura MT, Worm M, Del Giacco S, Benetos A, Bilo BM, Czarlewski W, Abdul Latiff AH, Al-Ahmad M, Angier E, Annesi-Maesano I, Atanaskovic-Markovic M, Bachert C, Barbaud A, Bedbrook A, Bennoor KS, Berghea EC, Bindslev-Jensen C, Bonini S, Bosnic-Anticevich S, Brockow K, Brussino L, Camargos P, Canonica GW, Cardona V, Carreiro-Martins P, Carriazo A, Casale T, Caubet J-C, Cecchi L, Cherubini A, Christoff G, Chu DK, Cruz AA, Dokic D, El-Gamal Y, Ebisawa M, Eberlein B, Farrell J, Fernandez-Rivas M, Fokkens WJ, Fonseca JA, Gao Y, Gavazzi G, Gawlik R, Gelincik A, Gemicioglu B, Gotua M, Guerin O, Haahtela T, Hoffmann-Sommergruber K, Hoffmann HJ, Hofmann M, Hrubisko M, Illario M, Irani C, Ispayeva Z, Ivancevich JC, Julge K, Kaidashev I, Khaitov M, Knol E, Kraxner H, Kuna P, Kvedariene V, Lauerma A, Le LTT, Le Moing V, Levin M, Louis R, Lourenco O, Mahler V, Martin FC, Matucci A, Milenkovic B, Miot S, Montella E, Morais-Almeida M, Mortz CG, Mullol J, Namazova-Baranova L, Neffen H, Nekam K, Niedoszytko M, Odemyr M, O'Hehir RE, Okamoto Y, Ollert M, Palomares O, Papadopoulos NG, Panzner P, Passalacqua G, Patella V, Petrovic M, Pfaar O, Pham-Thi N, Plavec D, Popov TA, Recto MT, Regateiro FS, Reynes J, Roller-Winsberger RE, Rolland Y, Romano A, Rondon C, Rottem M, Rouadi PW, Salles N, Samolinski B, Santos AF, Sarquis F, Sastre J, M G A Schols J, Scichilone N, Sediva A, Shamji MH, Sheikh A, Skypala I, Smolinska S, Sokolowska M, Sousa-Pinto B, Sova M, Stelmach R, Sturm G, Suppli Ulrik C, Todo-Bom AM, Toppila-Salmi S, Tsiligianni I, Torres M, Untersmayr E, Urrutia Pereira M, Valiulis A, Vitte J, Vultaggio A, Wallace D, Walusiak-Skorupa J, Wang D-Y, Waserman S, Yorgancioglu A, Yusuf OM, Zernotti M, Zidarn M, Chivato T, Akdis CA, Zuberbier T, Klimek Let al., 2021, Management of anaphylaxis due to COVID-19 vaccines in the elderly, ALLERGY, Vol: 76, Pages: 2952-2964, ISSN: 0105-4538

Journal article

Boyle RJ, Shamji MH, 2021, Allergy societies and the formula industry, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1260-1261, ISSN: 0954-7894

Journal article

Pfaar O, Bousquet J, Durham SR, Kleine-Tebbe J, Larche M, Roberts G, Shamji MH, van Wijk RGet al., 2021, One hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence, ALLERGY, Vol: 77, Pages: 454-468, ISSN: 0105-4538

Journal article

Warren CM, Snow TT, Lee AS, Shah MM, Heider A, Blomkalns A, Betts B, Buzzanco AS, Gonzalez J, Chinthrajah RS, Do E, Chang I, Dunham D, Lee G, O'Hara R, Park H, Shamji MH, Schilling L, Sindher SB, Sisodiya D, Smith E, Tsai M, Galli SJ, Akdis C, Nadeau KCet al., 2021, Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System., JAMA Netw Open, Vol: 4

Importance: As of May 2021, more than 32 million cases of COVID-19 have been confirmed in the United States, resulting in more than 615 000 deaths. Anaphylactic reactions associated with the Food and Drug Administration (FDA)-authorized mRNA COVID-19 vaccines have been reported. Objective: To characterize the immunologic mechanisms underlying allergic reactions to these vaccines. Design, Setting, and Participants: This case series included 22 patients with suspected allergic reactions to mRNA COVID-19 vaccines between December 18, 2020, and January 27, 2021, at a large regional health care network. Participants were individuals who received at least 1 of the following International Statistical Classification of Diseases and Related Health Problems, Tenth Revision anaphylaxis codes: T78.2XXA, T80.52XA, T78.2XXD, or E949.9, with documentation of COVID-19 vaccination. Suspected allergy cases were identified and invited for follow-up allergy testing. Exposures: FDA-authorized mRNA COVID-19 vaccines. Main Outcomes and Measures: Allergic reactions were graded using standard definitions, including Brighton criteria. Skin prick testing was conducted to polyethylene glycol (PEG) and polysorbate 80 (P80). Histamine (1 mg/mL) and filtered saline (negative control) were used for internal validation. Basophil activation testing after stimulation for 30 minutes at 37 °C was also conducted. Concentrations of immunoglobulin (Ig) G and IgE antibodies to PEG were obtained to determine possible mechanisms. Results: Of 22 patients (20 [91%] women; mean [SD] age, 40.9 [10.3] years; 15 [68%] with clinical allergy history), 17 (77%) met Brighton anaphylaxis criteria. All reactions fully resolved. Of patients who underwent skin prick tests, 0 of 11 tested positive to PEG, 0 of 11 tested positive to P80, and 1 of 10 (10%) tested positive to the same brand of mRNA vaccine used to vaccinate that individual. Among these same participants, 10 of 11 (91%) had positive basophil activation tes

Journal article

Boyle RJ, Shamji MH, 2021, Asthma management and impact on COVID-19 outcomes, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1100-1102, ISSN: 0954-7894

Journal article

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