Publications
357 results found
Turner PJ, McMahon O, Switzer A, et al., 2015, Marked Increase in Basophil Activation during Non-Anaphylactic Allergic Reactions to Peanut in Man, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB33-AB33, ISSN: 0091-6749
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- Citations: 3
Shamji MH, Ceuppens JL, Hellings PW, et al., 2015, Immunogenicity Evaluation of Subcutaneous Administration of Peptide Hydrolysate from Lolium Perenne (gpASIT plus ™) in Combination with Bacterial HSP70 (DnaK) in Patients with Seasonal Allergic Rhinitis: A Double Blind Placebo Controlled Trial, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB159-AB159, ISSN: 0091-6749
Turner P, Mehr S, Sayers R, et al., 2015, Tolerance to boiled peanut in peanut-allergic children: are boiled peanuts an option for oral immunotherapy?, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 530-530, ISSN: 0954-7894
Shamji MH, Bellido V, Scadding GW, et al., 2015, Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals, ALLERGY, Vol: 70, Pages: 171-179, ISSN: 0105-4538
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- Citations: 27
Lao-Araya M, Steveling E, Scadding GW, et al., 2014, Seasonal increases in peripheral innatelymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 134, Pages: 1193-1195, ISSN: 0091-6749
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- Citations: 143
Turner PJ, Mehr S, Sayers R, et al., 2014, Tolerance to boiled peanut in peanut-allergic children: potential for oral immunotherapy?, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 382-382, ISSN: 0105-4538
Zadoyan G, Hauswald B, Yarin Y, et al., 2014, Safety, clinical tolerability and immunogenicity of increasing doses of gpASIT plus ™ administered subcutaneously to hay fever patients - a phase IIa dose-escalation study, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 154-154, ISSN: 0105-4538
Mehr S, Turner PJ, Campbell DE, et al., 2014, TOLERANCE TO BOILED PEANUT IN PEANUT-ALLERGIC CHILDREN, INTERNAL MEDICINE JOURNAL, Vol: 44, Pages: 17-17, ISSN: 1444-0903
Shamji MH, Ceuppens J, Hellings P, et al., 2014, Immunogenicity evaluation of subcutaneous administration of peptide hydrolysate from Lolium perenne (gpASIT plus TM) in combination with bacterial HSP70 (DnaK) in patients with seasonal allergic rhinitis, European-Academy-of-Allergy-and-Clinical-Immunology Congress, Publisher: WILEY-BLACKWELL, Pages: 31-31, ISSN: 0105-4538
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- Citations: 1
Turner PJ, Mehr S, Sayers R, et al., 2014, Loss of allergenic proteins during boiling explains tolerance to boiled peanut in peanut allergy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 134, Pages: 751-753, ISSN: 0091-6749
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- Citations: 38
Lao-Araya M, Steveling E, Scadding GW, et al., 2014, Seasonal Increases in peripheral innate lymphoid type 2 cells (ILC2s) are inhibited by grass pollen immunotherapy, ALLERGY, Vol: 69, Pages: 608-609, ISSN: 0105-4538
Jones M, Jeal H, Schofield S, et al., 2014, Rat-specific IgG and IgG(4) antibodies associated with inhibition of IgE-allergen complex binding in laboratory animal workers, Occupational and Environmental Medicine, Vol: 71, Pages: 619-623, ISSN: 1470-7926
Objectives The relationship between exposure torodent allergens and laboratory animal allergy iscomplex; at highest allergen exposures there is anattenuation of sensitisation and symptoms which areassociated with increased levels of rat-specificimmunoglobulin (Ig)G and IgG4 antibodies. We set outto examine whether the increased levels of rat-specificIgG and IgG4 antibodies that we have previouslyobserved at high allergen exposure in our cohort oflaboratory animal workers play a functional role throughblockage of the binding of IgE–allergen complex bindingto CD23 receptors on B cells.Methods Cross-sectional survey of laboratory animalworkers (n=776) in six UK pharmaceutical companieswere surveyed. IgE–allergen complex binding to B cellswas measured in 703 (97.9%) eligible employees; theirexposure was categorised by either job group or numberof rats handled daily.Results We observed a significant decrease inIgE–allergen complex binding to B cells with increasingquartiles of both rat-specific IgG and IgG4 antibodies(p<0.001). IgE–allergen complex binding to B cells waslower in workers with high allergen exposure, andsignificantly so (p=0.033) in the subgroup with highestexposures but no work-related chest symptoms.Conclusions These findings demonstrate a functionalrole for rat-specific IgG/G4 antibodies in laboratoryanimal workers, similar to that observed in patientstreated with high dose immunotherapy who becomeclinically tolerant, suggesting a potential explanation forthe attenuation of risk at highest allergen exposures.
Pillai P, Fang C, Chan Y-C, et al., 2014, Allergen-specific IgE is not detectable in the bronchial mucosa of nonatopic asthmatic patients, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 133, Pages: 1770-1772, ISSN: 0091-6749
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- Citations: 21
Shamji MH, 2014, Mechanisms of Allergen-Specific Sublingual Immunotherapy and the Use of Biological Markers in Allergic Rhinitis, Current Treatment Options in Allergy, Vol: 1
Clinical and immunologic tolerance are hallmarks of successful allergen sublingual immunotherapy (SLIT) in carefully selected patients. Clinical benefit such as reduced symptoms, pharmacotherapy intake, and improvement of quality of life persists following discontinuation of treatment. Successful SLIT is associated with suppression of allergic inflammatory cells such as mast cells, eosinophils, and basophils. Furthermore, SLIT immunomodulates allergen-specific Th2 responses in the tissue (target organ) and the periphery. The immunologic tolerant state induced following SLIT is associated with induction of allergen-specific IL-10+, TGF-β+, and FoxP3+ regulatory memory T cells. B cell responses, in particular IgG4-associated blocking antibodies and IL-10+ regulatory B cells, are also induced following allergen immunotherapy (AIT). These events are followed by suppression of allergen-specific proliferation Th2 responses and result in immune deviation from a T helper 2-type to T helper 1-type response. Despite insight gained with regard to the mechanisms of SLIT, to date there are no validated biomarkers that are predictive of the clinical response to treatment. This review reports recent advances in understanding mechanisms of SLIT and outlines relevant potential biomarkers for monitoring allergen-specific immunotherapy.
Wood RA, Togias A, Wildfire J, et al., 2014, Development of cockroach immunotherapy by the Inner-City Asthma Consortium, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 133, Pages: 846-+, ISSN: 0091-6749
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- Citations: 40
Zhang J, Steveling E, Yan R, et al., 2014, Local 'Protective' IgG4 Antibodies In Nasal Fluid Are Elevated Following Grass Pollen Immunotherapy, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB157-AB157, ISSN: 0091-6749
Shamji MH, Layhadi J, Perera-web A, et al., 2014, IL-35-Producing T Cells (iTR35) Inhibit Th2 Effector Function, Induce Infectious Tolerance and Are Elevated Following Grass Pollen Sublingual Immunotherapy, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB51-AB51, ISSN: 0091-6749
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- Citations: 1
Matsuoka T, Yan R, Scadding GW, et al., 2014, Interleukin IL-27+Dendritic Cells Modulate Ex-Vivo Th2 Responses In a Pdl-1-Dependent Manner and Increase In-Vivo Following Grass Pollen Immunotherapy, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB157-AB157, ISSN: 0091-6749
Charlesworth JEG, Scadding GW, Eifan A, et al., 2014, IL-10-Producing B Cells Are Increased After Grass Pollen Immunotherapy Compared To Untreated Grass Pollen Allergic Controls: A Blinded Cross-Sectional Study, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB53-AB53, ISSN: 0091-6749
Vickery BP, Scurlock AM, Kulis M, et al., 2014, Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 133, Pages: 468-+, ISSN: 0091-6749
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- Citations: 309
Couto-Francisco NC, Matsuoka T, Yan R, et al., 2014, Interleukin 35 Modulates TSLP, IL-25 and IL-33 Primed Dendritic Cells and Inhibits Naive T Cell Differentiation and Grass Pollen-Specific T Cell Proliferation, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB149-AB149, ISSN: 0091-6749
Scadding GW, Eifan A, Lao-Araya M, et al., 2014, Grass Pollen Immunotherapy: Impaired Allergen-Induced Nasal and Cutaneous Responses Correlate With Overall Seasonal Symptom Scores and Are Associated With Suppressed Local Th2 Cytokines In Nasal Fluid, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB158-AB158, ISSN: 0091-6749
Shamji MH, Till SJ, Durham SR, 2014, Immunological Responses to Subcutaneous Allergen Immunotherapy, ALLERGENS AND ALLERGEN IMMUNOTHERAPY: SUBCUTANEOUS, SUBLINGUAL,AND ORAL, 5TH EDITION, Editors: Lockey, Ledford, Publisher: CRC PRESS-TAYLOR & FRANCIS GROUP, Pages: 51-65, ISBN: 978-1-84214-573-9
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- Citations: 1
Matsuoka T, Shamji MH, Durham SR, 2013, Allergen Immunotherapy and Tolerance, ALLERGOLOGY INTERNATIONAL, Vol: 62, Pages: 403-413, ISSN: 1323-8930
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- Citations: 65
Matsuoka T, Durham SR, Shamji MH, 2013, Interleukin 27-primed dendritic cells suppress grass pollen-specific Th2 responses in patients with seasonal allergic rhinitis, Annual Meeting of the British-Society-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 1438-1438, ISSN: 0954-7894
Pillai P, Fang C, Chan C, et al., 2013, Detection and quantitation of total and allergen specific IgE in the bronchial mucosa of atopic and non-atopic asthmatics, Annual Meeting of the British-Society-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 1441-1441, ISSN: 0954-7894
Charlesworth J, Goldstone A, Yan R, et al., 2013, Regulatory B cells are reduced amongst grass-pollen allergic patients compared with non-allergic controls, Annual Meeting of the British-Society-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 1429-1429, ISSN: 0954-7894
Marri E, Nayak A, Qaseem A, et al., 2013, Modulation of DC-SIGN-allergen interaction by surfactant protein SP-D, Annual Meeting of the British-Society-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 1437-1437, ISSN: 0954-7894
Shamji MH, Francis JN, Wuertzen PA, et al., 2013, Cell-free detection of allergen-IgE cross-linking with immobilized phase CD23: Inhibition by blocking antibody responses after immunotherapy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 1003-+, ISSN: 0091-6749
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- Citations: 45
Qaseem A, Pathan A, Layhadi J, et al., 2013, Recombinant human pulmonary surfactant protein-D (rhSP-D) modulates Th2 responses and suppresses IgE-facilitated allergen binding to B cells, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
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