Publications
357 results found
Shamji MH, Matsuoka T, Durham SR, 2013, IL-27 supresses allergen-driven TH2 responses and IL-27+dendritic cells are significantly reduced in grass pollen allergic individuals compared to non-atopic controls, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 23-23, ISSN: 0105-4538
Cifuentes L, Ploetz S, Chaker A, et al., 2013, <i>In vitro</i> immunomonitoring of birch pollen-allergic patients during allergen-specific immunotherapy, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 468-469, ISSN: 0105-4538
Qaseem AS, Pathan AA, Layhadi JA, et al., 2013, Recombinant human pulmonary surfactant protein-D (rhSP-D) modulates Th2 responses and suppresses IgE-facilitated allergen binding to B cells, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 48-48, ISSN: 0105-4538
Shamji MH, Layhadi JA, Scadding GW, et al., 2013, A novel subset of regulatory T cells: interleukin-35 producing T regs (iTR35) are induced after grass pollen sublingual immunotherapy, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 67-67, ISSN: 0105-4538
Shamji MH, Saleem N, Nicholson J, et al., 2013, Local nasal antiinflammatory IgG4 responses are induced following grass pollen sublingual and subcutaneous immunotherapy, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 21-22, ISSN: 0105-4538
Slovick A, Douiri A, Kelly J, et al., 2013, Protocol for a double-blind randomised controlled trial of low dose intradermal grass pollen immunotherapy versus a histamine control on symptoms and medication use in adults with seasonal allergic rhinitis (PollenLITE)., Clin Transl Allergy, Vol: 3, ISSN: 2045-7022
BACKGROUND: Subcutaneous immunotherapy with high dose grass pollen (typically microgram quantities) was first described over 100 years ago. This treatment suppresses allergen-induced cutaneous late responses, with lesser effects on early responses. We previously reported that repeated 2-weekly intradermal injections of grass pollen - containing approximately 7 ng of major allergen Phl p 5 - led to a progressive suppression of the allergen-induced cutaneous response, and that by the sixth injection, this was inhibited by over 90%. The purpose of this trial is to investigate the clinical efficacy of intradermal desensitisation with low doses (i.e. nanogram quantities) of grass pollen allergen for seasonal allergic rhinitis. METHODS/DESIGN: The Pollen Low dose Intradermal therapy Evaluation (PollenLITE) is a single centre double-blind randomised parallel group controlled trial of the efficacy and safety of intradermal grass pollen injections plus standard treatment, versus histamine injections plus standard treatment, in adults with moderate-severe grass pollen-induced allergic rhinitis ('summer hay fever'). A minimum of ninety adults with a history of moderate-severe persistent allergic rhinitis during the UK grass pollen season will be randomised into two equal groups to receive 7 or 8 intradermal injections of grass pollen extract (containing approximately 7 ng of major allergen Phl p 5) or histamine, before the grass pollen season. In the summer, participants will score their symptoms, medication requirements, visual analogue scores, and complete EuroQOL (EQ-5D-5 L) and mini Rhinoconjunctivitis Quality of Life Questionnaires. Global assessments will also be recorded at the end of the pollen season. Blood samples will be collected from all participants for mechanistic immune assays. Skin punch biopsies will also be collected in 40 participants selected at random from intradermal injection sites after the grass pollen season for mechanistic assays
Varga E-M, Kausar F, Aberer W, et al., 2013, Tolerant beekeepers display venom-specific functional IgG<sub>4</sub> antibodies in the absence of specific IgE, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 131, Pages: 1419-1421, ISSN: 0091-6749
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- Citations: 40
Qaseem AS, Sonar S, Mahajan L, et al., 2013, Linking surfactant protein SP-D and IL-13: Implications in asthma and allergy, MOLECULAR IMMUNOLOGY, Vol: 54, Pages: 98-107, ISSN: 0161-5890
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- Citations: 32
Marth K, Breyer I, Focke-Tejkl M, et al., 2013, A Nonallergenic Birch Pollen Allergy Vaccine Consisting of Hepatitis PreS-Fused Bet v 1 Peptides Focuses Blocking IgG toward IgE Epitopes and Shifts Immune Responses to a Tolerogenic and Th1 Phenotype, JOURNAL OF IMMUNOLOGY, Vol: 190, Pages: 3068-3078, ISSN: 0022-1767
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- Citations: 53
Shamji MH, Ljorring C, Wurtzen PA, 2013, Predictive biomarkers of clinical efficacy of allergen-specific immunotherapy: how to proceed, IMMUNOTHERAPY, Vol: 5, Pages: 203-206, ISSN: 1750-743X
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- Citations: 16
Matsuoka T, Chun FW, Stott B, et al., 2013, Immunomodulatory Effects of IL-27 On Allergen-Induced Th2 Responses, Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB203-AB203, ISSN: 0091-6749
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- Citations: 4
Pillai PC, Fang C, Chan Y-C, et al., 2013, Detection and Quantitation of Total and Allergen-Specific IgE in the Bronchial Mucosa of Atopic and Non-Atopic Asthmatics, Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB331-AB331, ISSN: 0091-6749
Shamji M, Layhadi J, Perera-Web A, et al., 2013, IL-35+Regulatory T Cells Suppress Grass Pollen-Driven Th2 Responses and Are Induced Following Grass Pollen-Specific Sublingual Immunotherapy, Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB146-AB146, ISSN: 0091-6749
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- Citations: 1
Saleem N, Chaker A, Zissler U, et al., 2013, Local Nasal 'Protective' Immunoglobulin G4 (IgG4) Responses in Nasal Fluid Following Grass Pollen Sublingual Immunotherapy, Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB202-AB202, ISSN: 0091-6749
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- Citations: 2
Charlesworth JEG, Goldstone A, Calderon MA, et al., 2013, Grass Pollen Allergics Have Fewer IL-10-Producing B Cells Than Non-Atopic Controls, Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB204-AB204, ISSN: 0091-6749
Durham SR, Scadding GW, Phippard D, et al., 2013, Biomarkers of tolerance in response to allergen immunotherapy., Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess, Vol: 97, Pages: 75-81
Rotiroti G, Shamji M, Till SJ, et al., 2012, Repeated low dose intradermal allergen injection suppresses allergen-induced cutaneous late responses, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1817-1818, ISSN: 0954-7894
Qaseem A, Pathan AA, Layhadi JA, et al., 2012, Recombinant human pulmonary surfactant protein-D (rhSP-D) suppresses IgE-facilitated allergen binding to B cells, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1826-1826, ISSN: 0954-7894
Shamji MH, Achkova D, Layhadi JA, et al., 2012, IL-35 producing regulatory T cells modulate grass pollen-specific Th2 responses and are induced following sublingual grass pollen immunotherapy, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1816-1817, ISSN: 0954-7894
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- Citations: 3
Charlesworth JEG, Khan SMQ, Scadding GW, et al., 2012, IL-10-producing regulatory B cells suppress allergen-specific T cell proliferation and are elevated ex vivo following specific immunotherapy, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), Publisher: WILEY-BLACKWELL, Pages: 1817-1817, ISSN: 0954-7894
Shamji M, Patel V, Till S, et al., 2012, Functional but not quantitative peanut-specific IgE antibodies as diagnostic biomarker for peanut allergy, 31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 59-60, ISSN: 0105-4538
Shamji M, Kent A, Baron-Bodo V, et al., 2012, Pre-coseasonal treatment with five-grass sublingual tablets induces inhibitory antibodies that correlate with clinical efficacy, 31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 33-33, ISSN: 0105-4538
Shamji M, Achkova D, Chung W, et al., 2012, Inducible IL-35+T regs attenuate allergen-specific Th2 and Th17 responses in patients with seasonal allergic rhinitis, 31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 55-55, ISSN: 0105-4538
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- Citations: 1
Rotiroti G, Shamji M, Durham SR, et al., 2012, Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 130, Pages: 918-+, ISSN: 0091-6749
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- Citations: 31
James LK, Bowen H, Calvert RA, et al., 2012, Allergen specificity of IgG<sub>4</sub>-expressing B cells in patients with grass pollen allergy undergoing immunotherapy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 130, Pages: 663-+, ISSN: 0091-6749
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- Citations: 70
Herranz F, Schmidt-Weber CB, Shamji MH, et al., 2012, Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe, CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 7, Pages: 435-439, ISSN: 1555-4309
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- Citations: 7
Shamji MH, Bellido V, Scadding G, et al., 2012, Effects of Nasal Allergen Challenge on T cell signature in Peripheral Blood in Patients with Severe Seasonal Allergic Rhinitis, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB196-AB196, ISSN: 0091-6749
Shamji MH, Ljorring C, Francis JN, et al., 2012, Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy, ALLERGY, Vol: 67, Pages: 217-226, ISSN: 0105-4538
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- Citations: 211
Achkova D, Chung FW, Leyhadi JA, et al., 2012, Interleukin-35 Suppresses Allergen-specific Th2 Response in Patients with Grass pollen induced Seasonal Allergic Rhinitis, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB208-AB208, ISSN: 0091-6749
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- Citations: 2
Eifan AO, Shamji MH, Durham SR, 2011, Long-term clinical and immunological effects of allergen immunotherapy, CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 11, Pages: 586-593, ISSN: 1528-4050
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- Citations: 69
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