Imperial College London
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ProfessorMohamedShamji

Faculty of Medicine, National Heart & Lung Institute

Professor of Immunology and Allergy
 
 
 
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Contact

 

+44 (0)20 7594 3476m.shamji99 Website

 
 
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Location

 

Room 111Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shamji:2023:10.1111/cea.14292,
author = {Shamji, MH and Boyle, RJ},
doi = {10.1111/cea.14292},
journal = {Clin Exp Allergy},
pages = {130--131},
title = {Biological therapy practice, biomarkers of severe asthma and novel approaches for attaining immunomodulation in upper airway disease.},
url = {http://dx.doi.org/10.1111/cea.14292},
volume = {53},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The hybrid rDer p 2231 stimulated in PBMCs isolated from atopic patients, higher levels of IL-2, IL-10, IL-15 and IFN-γ, as well as lower levels of IL-4, IL-5, IL-13, TNF-α and GM-CSF. The use of hybrid molecules as a therapeutic model in D. pteronyssinus allergic mice led to the reduction of IgE production and lower eosinophilic peroxidase activity in the airways. We found increased levels of IgG antibodies, which blocked the IgE binding to the parental allergens in serum of atopic patients. Furthermore, the stimulation of splenocytes from mice treated with rDer p 2231 induced higher levels of IL-10 and IFN-γ and decreased the secretion of IL-4 and IL-5, when compared to parental allergens and D. pteronyssinus extract. (7).
AU  - Shamji,MH
AU  - Boyle,RJ
DO  - 10.1111/cea.14292
EP  - 131
PY  - 2023///
SP  - 130
TI  - Biological therapy practice, biomarkers of severe asthma and novel approaches for attaining immunomodulation in upper airway disease.
T2  - Clin Exp Allergy
UR  - http://dx.doi.org/10.1111/cea.14292
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36793185
VL  - 53
ER  -
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