Imperial College London
Portrait Picture

ProfessorMohamedShamji

Faculty of Medicine, National Heart & Lung Institute

Professor of Immunology and Allergy
 
 
 
//

Contact

 

+44 (0)20 7594 3476m.shamji99 Website

 
 
//

Location

 

Room 111Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Magnan:2023:10.3390/jpm13020324,
author = {Magnan, A and Nicolas, J-F and Caimmi, D and Vocanson, M and Haddad, T and Colas, L and Scurati, S and Mascarell, L and Shamji, MH},
doi = {10.3390/jpm13020324},
journal = {J Pers Med},
title = {Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy.},
url = {http://dx.doi.org/10.3390/jpm13020324},
volume = {13},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Like in many fields of medicine, the concept of precision dosing has re-emerged in routine practice in allergology. Only one retrospective study on French physicians' practice has addressed this topic so far and generated preliminary data supporting dose adaptation, mainly based on experience, patient profile understanding and response to treatment. Both intrinsic and extrinsic factors shape the individual immune system response to allergen immunotherapy (AIT). Herein, we focus on key immune cells (i.e., dendritic cells, innate lymphoid cells, B and T cells, basophils and mast cells) involved in allergic disease and its resolution to further understand the effect of AIT on the phenotype, frequency or polarization of these cells. We strive to discriminate differences in immune responses between responders and non-responders to AIT, and discuss the eligibility of a non/low-responder subset for dose adaptation. A differential behavior in immune cells is clearly observed in responders, highlighting the importance of conducting clinical trials with large cohorts of well-characterized subjects to decipher the immune mechanism of AIT. We conclude that there is a need for designing new clinical and mechanistic studies to support the scientific rationale of dose adaptation in the interest of patients who do not properly respond to AIT.
AU  - Magnan,A
AU  - Nicolas,J-F
AU  - Caimmi,D
AU  - Vocanson,M
AU  - Haddad,T
AU  - Colas,L
AU  - Scurati,S
AU  - Mascarell,L
AU  - Shamji,MH
DO  - 10.3390/jpm13020324
PY  - 2023///
SN  - 2075-4426
TI  - Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy.
T2  - J Pers Med
UR  - http://dx.doi.org/10.3390/jpm13020324
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36836557
VL  - 13
ER  -
Download