Imperial College London
Alternate

ProfessorMurrayShanahan

Faculty of Engineering, Department of Computing

Professor in Cognitive Robotics
 
 
 
//

Contact

 

+44 (0)20 7594 8262m.shanahan Website

 
 
//

Location

 

407BHuxley BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Hellyer:2014:10.1523/JNEUROSCI.1853-13.2014,
author = {Hellyer, PJ and Shanahan, MP and Scott, G and Wise, RJS and Sharp, DJ and Leech, R},
doi = {10.1523/JNEUROSCI.1853-13.2014},
journal = {Journal of Neuroscience},
pages = {451--461},
title = {The control of global brain dynamics: opposing actions of frontoparietal control and default mode networks on attention},
url = {http://dx.doi.org/10.1523/JNEUROSCI.1853-13.2014},
volume = {34},
year = {2014}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Understanding how dynamic changes in brain activity control behavior is a major challenge of cognitive neuroscience. Here, we consider the brain as a complex dynamic system and define two measures of brain dynamics: the synchrony of brain activity, measured by the spatial coherence of the BOLD signal across regions of the brain; and metastability, which we define as the extent to which synchrony varies over time. We investigate the relationship among brain network activity, metastability, and cognitive state in humans, testing the hypothesis that global metastability is “tuned” by network interactions. We study the following two conditions: (1) an attentionally demanding choice reaction time task (CRT); and (2) an unconstrained “rest” state. Functional MRI demonstrated increased synchrony, and decreased metastability was associated with increased activity within the frontoparietal control/dorsal attention network (FPCN/DAN) activity and decreased default mode network (DMN) activity during the CRT compared with rest. Using a computational model of neural dynamics that is constrained by white matter structure to test whether simulated changes in FPCN/DAN and DMN activity produce similar effects, we demonstate that activation of the FPCN/DAN increases global synchrony and decreases metastability. DMN activation had the opposite effects. These results suggest that the balance of activity in the FPCN/DAN and DMN might control global metastability, providing a mechanistic explanation of how attentional state is shifted between an unfocused/exploratory mode characterized by high metastability, and a focused/constrained mode characterized by low metastability.
AU  - Hellyer,PJ
AU  - Shanahan,MP
AU  - Scott,G
AU  - Wise,RJS
AU  - Sharp,DJ
AU  - Leech,R
DO  - 10.1523/JNEUROSCI.1853-13.2014
EP  - 461
PY  - 2014///
SN  - 1529-2401
SP  - 451
TI  - The control of global brain dynamics: opposing actions of frontoparietal control and default mode networks on attention
T2  - Journal of Neuroscience
UR  - http://dx.doi.org/10.1523/JNEUROSCI.1853-13.2014
UR  - http://www.jneurosci.org/content/34/2/451.short
UR  - http://hdl.handle.net/10044/1/23331
VL  - 34
ER  -
Download